{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:20:32Z","timestamp":1777659632870,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T00:00:00Z","timestamp":1421193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T00:00:00Z","timestamp":1421193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2015,2,1]]},"abstract":"<jats:p>\n                    In the normal population, loss of one of the sex chromosomes leading to monosomy (45,X) is a part of the aging process. In Turner syndrome (TS), the classic karyotype 45,X is found in up to 50% at birth, and others have a second cell line; mosaicism. The aim was to study if the chromosomal pattern in TS women changes over time. Fluorescence\n                    <jats:italic toggle=\"yes\">in situ<\/jats:italic>\n                    hybridization was performed on buccal smear cells obtained twice, 10 years apart, from 42 women with TS aged 26-66 years (mean\u00b1standard deviation: 42.0\u00b111.6). DNA probes specific for chromosomes X (DXZ1) and Y (DYZ3) were used and &gt;100 cells were analyzed\/patient. Nineteen women had monosomy (45,X) (&lt;10% 46,XX), nine had 45,X\/46,XX mosaicism, and 14 had iso, ring, or a marker chromosome at baseline. At 10 years, the percentage of diploid cells had increased in 29 of 42 women (69%), with an average increase of 5.7\u00b113.0%. There was a positive correlation between age and % change in diploid 46,XX or 46,XY cells (\n                    <jats:italic toggle=\"yes\">r<\/jats:italic>\n                    =0.38,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.023). This new finding might have relevance for the life expectancy in TS.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2014.0240","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T10:47:51Z","timestamp":1421232471000},"page":"82-87","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["The Proportion of Diploid 46,XX Cells Increases with Time in Women with Turner Syndrome\u2014A 10-Year Follow-Up Study"],"prefix":"10.1177","volume":"19","author":[{"given":"Anna-Maria","family":"Denes","sequence":"first","affiliation":[{"name":"Chalmers University of Technology","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Landin-Wilhelmsen","sequence":"additional","affiliation":[{"name":"University of Gothenburg","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Wettergren","sequence":"additional","affiliation":[{"name":"University of Gothenburg","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger","family":"Bryman","sequence":"additional","affiliation":[{"name":"University of Gothenburg","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Hanson","sequence":"additional","affiliation":[{"name":"University of Gothenburg","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,1,14]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(00)00040-X"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1374"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02807.x"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2966"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000130842"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1510657"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951106000928"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363945"},{"key":"e_1_3_3_10_1","first-page":"1143","article-title":"Sex-chromosome loss and aging - in-situ hybridization studies on human interphase nuclei","volume":"57","author":"Guttenbach M","year":"1995","unstructured":"Guttenbach M, , Koschorz B, , Bernthaler U, et al. (1995) Sex-chromosome loss and aging - in-situ hybridization studies on human interphase nuclei. Am J Hum Genet, 57:1143-1150.","journal-title":"Am J Hum Genet"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2001.080004331.x"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.2001.00153.x"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00289473"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/9.3.147"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00290218"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01213097"},{"key":"e_1_3_3_17_1","first-page":"1101","article-title":"The frequency of aneuploidy in cultured lymphocytes is correlated with age and gender but not with reproductive history","volume":"46","author":"Nowinski GP","year":"1990","unstructured":"Nowinski GP, , Vandyke DL, , Tilley BC, et al. (1990) The frequency of aneuploidy in cultured lymphocytes is correlated with age and gender but not with reproductive history. 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