{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:20:44Z","timestamp":1777659644174,"version":"3.51.4"},"reference-count":50,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T00:00:00Z","timestamp":1425600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:p>\n                    Nitric oxide (NO), produced by the enzyme endothelial nitric oxide synthase (\n                    <jats:italic toggle=\"yes\">eNOS<\/jats:italic>\n                    ), has critical roles in the regulation of vascular homeostasis and prevention of atherogenesis by inhibiting leukocytes, platelet activation, and smooth muscle cell proliferation. There is strong experimental and clinical evidence that abnormalities in\n                    <jats:italic toggle=\"yes\">eNOS<\/jats:italic>\n                    availability play an important role in the pathophysiology of coronary artery disease (CAD). Controversial results regarding the association of\n                    <jats:italic toggle=\"yes\">eNOS<\/jats:italic>\n                    gene polymorphisms with CAD have been reported. The aim of this study is to investigate the relationship of the 894G&gt;T (rs1799983) and 4a\/4b (rs61722009) polymorphisms of the\n                    <jats:italic toggle=\"yes\">eNOS<\/jats:italic>\n                    gene with the presence of CAD in the Tunisian population. A total of 332 patients with CAD and 368 controls were included in this study. The 894G&gt;T (rs1799983) single-nucleotide polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism, and 4a\/4b (rs61722009) polymorphism just by polymerase chain reaction (PCR).\n                    <jats:italic toggle=\"yes\">eNOS<\/jats:italic>\n                    rs1799983 was significantly associated with CAD under the additive, dominant, but not recessive, models (additive model OR: 2.81; 95% CI [2.05-3.85];\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.001, dominant model OR: 2.84; 95% CI [2.09-3.86];\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt;0.001, and recessive models\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.09). This remained significant after adjustment for age, gender, diabetes, smoking, and hypertension. In contrast to\n                    <jats:italic toggle=\"yes\">eNOS<\/jats:italic>\n                    rs1799983,\n                    <jats:italic toggle=\"yes\">eNOS<\/jats:italic>\n                    rs61722009 was not associated with CAD under any of the genetic models tested. These findings suggest that the G894T (rs1799983) polymorphism of the\n                    <jats:italic toggle=\"yes\">eNOS<\/jats:italic>\n                    gene was associated with CAD in Tunisian patients.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2014.0261","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T15:56:05Z","timestamp":1425657365000},"page":"203-208","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Contribution of\n                    <i>eNOS<\/i>\n                    Variants to the Genetic Susceptibility of Coronary Artery Disease in a Tunisian Population"],"prefix":"10.1177","volume":"19","author":[{"given":"Marwa","family":"Ben Ali","sequence":"first","affiliation":[{"name":"University of Monastir","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safia","family":"Messaoudi","sequence":"additional","affiliation":[{"name":"University of Monastir","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houda","family":"Ezzine","sequence":"additional","affiliation":[{"name":"University of Monastir","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Touhami","family":"Mahjoub","sequence":"additional","affiliation":[{"name":"University of Monastir","place":["Tunisia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-2380-7"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/36.10.661"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2010.08.009"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.072"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613001"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.51.4.5"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-009-9572-9"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200502000-00001"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001099900020"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2004.12.002"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000121357.76910.A3"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.14.5.753"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.87.6.525"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.76.2.199"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/AC.68.1.2959627"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2007.11.011"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(01)00554-8"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114081"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/174182670100800408"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.09.037"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-003-0006-0"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.14.1515"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1521"},{"key":"e_1_3_2_25_1","first-page":"81","article-title":"Association of a polymorphism of the endothelial constitutive nitric oxide synthase gene with myocardial infarction in the Japanese population","volume":"6","author":"Ichihara S","year":"1998","unstructured":"Ichihara S, , Yamada Y, , Fujimura T, et al. 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