{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:20:46Z","timestamp":1777659646886,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2015,4,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Objective:<\/jats:italic>\n                    The objectives of this study were to determine the association between single nucleotide polymorphisms (SNPs) in\n                    <jats:italic toggle=\"yes\">IL1B<\/jats:italic>\n                    (\u2212511, +3954),\n                    <jats:italic toggle=\"yes\">IL1A<\/jats:italic>\n                    (\u2212889, +4845), and the variable number of tandem repeats (VNTRs) polymorphism in the IL-1RN gene with chronic periodontitis susceptibility and to analyze gene-gene interactions in a hospital-based sample population from South India.\n                    <jats:italic toggle=\"yes\">Subjects and Methods:<\/jats:italic>\n                    A total of 400 individuals were recruited for this study; 200 individuals with healthy gingiva and 200 chronic periodontitis patients. Genomic DNA was isolated from peripheral blood samples and genotyping was performed for the above-mentioned single nucleotide and VNTR polymorphisms by polymerase chain reaction, DNA sequencing, and agarose gel electrophoresis.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    A higher proportion of the variant alleles were observed in the chronic periodontitis group for all the SNPs examined. The SNP at +3954 (C&gt;T) in the\n                    <jats:italic toggle=\"yes\">IL1B<\/jats:italic>\n                    gene was found to be significantly associated with chronic periodontitis (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.007). VNTR genotypes (\n                    <jats:italic toggle=\"yes\">\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    value: 5.163, df=1,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.023) and alleles (\n                    <jats:italic toggle=\"yes\">\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    value: 6.818, df=1,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    =0.009) were found to have a significant association with chronic periodontitis susceptibility.\n                    <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    In the study population examined, the SNP in the\n                    <jats:italic toggle=\"yes\">IL1B<\/jats:italic>\n                    gene (+3954) and VNTR polymorphisms in the\n                    <jats:italic toggle=\"yes\">IL1RN<\/jats:italic>\n                    gene were found to have a significant association with chronic periodontitis susceptibility.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2014.0275","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T10:16:34Z","timestamp":1424772994000},"page":"175-181","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Polymorphic Regions in the Interleukin-1 Gene and Susceptibility to Chronic Periodontitis: A Genetic Association Study"],"prefix":"10.1177","volume":"19","author":[{"given":"Vamsi","family":"Lavu","sequence":"first","affiliation":[{"name":"Sri Ramachandra University","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vettriselvi","family":"Venkatesan","sequence":"additional","affiliation":[{"name":"Sri Ramachandra University","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhaskar","family":"Venkata Kameswara Subrahmanya Lakkakula","sequence":"additional","affiliation":[{"name":"Sickle Cell Institute Chhattisgarh","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Venugopal","sequence":"additional","affiliation":[{"name":"Sri Ramachandra University","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomon Franklin Durairaj","family":"Paul","sequence":"additional","affiliation":[{"name":"Sri Ramachandra University","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh Ranga","family":"Rao","sequence":"additional","affiliation":[{"name":"Sri Ramachandra 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