{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:11:39Z","timestamp":1779192699916,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T00:00:00Z","timestamp":1450137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2016,2,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Aim:<\/jats:italic>\n                    The purpose of this study was to evaluate the association of common polymorphisms in endothelial nitric oxide synthesis (\n                    <jats:italic toggle=\"yes\">eNOS<\/jats:italic>\n                    ; G894T) and renin-angiotensin-aldosterone system (angiotensin converting enzyme [\n                    <jats:italic toggle=\"yes\">ACE<\/jats:italic>\n                    ]\u2014I\/D, angiotensinogen\u2014T704C, and angiotensin II receptor type 1\u2014A1166C) as risk factors in the pathogenesis of coronary artery disease (CAD) in Bulgarian patients.\n                    <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    This study included 171 patients with CAD and 123 control subjects. Polymerase chain reaction-restriction fragment length polymorphism was used for studying the single-nucleotide polymorphisms. Statistical analysis was performed using statistical software PASW for Windows.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    A significantly higher percentage of the\n                    <jats:italic toggle=\"yes\">eNOS<\/jats:italic>\n                    T894 allele was found in patients with acute coronary syndrome (ACS), compared to controls (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.006) and patients with stable angina pectoris (SAP,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.005). Results from a binary regression analysis suggested that\n                    <jats:italic toggle=\"yes\">eNOS<\/jats:italic>\n                    T allele and\n                    <jats:italic toggle=\"yes\">ACE<\/jats:italic>\n                    D allele carriers were more likely to develop ACS than controls (T allele odds ratio [OR] 2.585,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.024; D allele OR 3.585,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.046) and patients with SAP (T allele OR 2.955,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.009; D allele OR 2.703,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.05). Exploratory evaluation of gene-gene combinations showed a significant association between\n                    <jats:italic toggle=\"yes\">eNOS<\/jats:italic>\n                    -G894T\/\n                    <jats:italic toggle=\"yes\">ACE<\/jats:italic>\n                    -I\/D and ACS compared to controls (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.022) and patients with SAP (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.017).\n                    <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    The\n                    <jats:italic toggle=\"yes\">eNOS<\/jats:italic>\n                    G894T and\n                    <jats:italic toggle=\"yes\">ACE<\/jats:italic>\n                    I\/D polymorphisms are associated with an increased risk of developing ACS after adjusting for classical risk factors for atherosclerosis in the Bulgarian cohort.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2015.0195","type":"journal-article","created":{"date-parts":[[2015,12,15]],"date-time":"2015-12-15T18:31:35Z","timestamp":1450204295000},"page":"67-73","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Association of Polymorphisms in Endothelial Nitric Oxide Synthesis and Renin-Angiotensin-Aldosterone System with Developing of Coronary Artery Disease in Bulgarian Patients"],"prefix":"10.1177","volume":"20","author":[{"given":"Katya","family":"Mokretar","sequence":"first","affiliation":[{"name":"Roumen Tzanev Institute of Molecular Biology","place":["Bulgaria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hristo","family":"Velinov","sequence":"additional","affiliation":[{"name":"Roumen Tzanev Institute of Molecular Biology","place":["Bulgaria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arman","family":"Postadzhiyan","sequence":"additional","affiliation":[{"name":"University Hospital \u201cSt. Anna,","place":["Bulgaria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Apostolova","sequence":"additional","affiliation":[{"name":"Roumen Tzanev Institute of Molecular Biology","place":["Bulgaria"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,12,15]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-2380-7"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2006.01.004"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079904X4185"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(01)00302-6"},{"key":"e_1_3_3_6_1","first-page":"213737","article-title":"Association of non-alcoholic fatty liver disease with subclinical cardiovascular changes: a systematic review and meta-analysis","volume":"2015","author":"Bonci E","year":"2015","unstructured":"Bonci E, , Chiesa C, , Versacci P, et al. (2015) Association of non-alcoholic fatty liver disease with subclinical cardiovascular changes: a systematic review and meta-analysis. Biomed Res, Int.2015:213737.","journal-title":"Biomed Res"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000121357.76910.A3"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.574"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.24.4.499"},{"key":"e_1_3_3_10_1","first-page":"674","article-title":"Long-term changes in the response of conductance and resistance coronary vessels to endothelium-dependent and independent vasodilators. A double-blind placebo-controlled study of the effect of a 6-month treatment with cilazapril","volume":"1","author":"Di Mario C","year":"2000","unstructured":"Di Mario C, , Strikwerda S, , Gil R, et al. (2000) Long-term changes in the response of conductance and resistance coronary vessels to endothelium-dependent and independent vasodilators. A double-blind placebo-controlled study of the effect of a 6-month treatment with cilazapril. Ital Heart J, 1:674-683.","journal-title":"Ital Heart J"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200101000-00017"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-013-2596-1"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.13-288"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.20.2.175"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90275-H"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep04207"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/db06-1321"},{"key":"e_1_3_3_18_1","first-page":"191","article-title":"Genetic polymorphism in angiotensin-converting enzyme gene and congenital anomalies of the kidney and urinary tract","volume":"12","author":"Kostadinova E","year":"2014","unstructured":"Kostadinova E, , Miteva L, , Stanilova S (2014) Genetic polymorphism in angiotensin-converting enzyme gene and congenital anomalies of the kidney and urinary tract. Trakia J Sci, 12:191-196.","journal-title":"Trakia J Sci"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000316063"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087196"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1470320315588872"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-6-1"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.19.11389"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2006.10.001"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.07.001"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2009.6"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199816100-00007"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1470320310361742"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.5812\/nephropathol.8109"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114844"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.10.3.463"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000370074"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2008.04.006"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/16.12.2323"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199715120-00003"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199816010-00007"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)11181-4"},{"key":"e_1_3_3_39_1","first-page":"326","article-title":"Restoration of endothelial function with ACE inhibitors","volume":"28","author":"Verma S","year":"2006","unstructured":"Verma S (2006) Restoration of endothelial function with ACE inhibitors. Medicographia, 28:326-332.","journal-title":"Medicographia"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.03091.x"}],"container-title":["Genetic Testing and Molecular Biomarkers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/gtmb.2015.0195","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/gtmb.2015.0195","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/gtmb.2015.0195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:02:56Z","timestamp":1779192176000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/gtmb.2015.0195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,15]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2,1]]}},"alternative-id":["10.1089\/gtmb.2015.0195"],"URL":"https:\/\/doi.org\/10.1089\/gtmb.2015.0195","relation":{},"ISSN":["1945-0265","1945-0257"],"issn-type":[{"value":"1945-0265","type":"print"},{"value":"1945-0257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,15]]}}}