{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:12:06Z","timestamp":1779192726833,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2016,8,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Background:<\/jats:italic>\n                    Polymorphisms in DNA repair genes can alter an individual's DNA repair capability and contribute to the risk of various cancers.\n                    <jats:italic toggle=\"yes\">Aims:<\/jats:italic>\n                    This study was designed to evaluate the association of single-nucleotide polymorphisms (SNPs) in the\n                    <jats:italic toggle=\"yes\">XPG<\/jats:italic>\n                    gene with the risk of gastric cardia adenocarcinoma (GCA) in a high-incidence population in northern China.\n                    <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    Two SNPs from 431 GCA patients and 432 healthy controls were genotyped using the polymerase chain reaction\/ligase detection reaction (PCR-LDR) method.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    The rs751402 C\/T SNP T allele and the T\/T genotype were associated with an increased risk of GCA in younger individuals (\u226461 years) (odds ratio [OR]\u2009=\u20091.33 and 1.77, 95% confidence interval [CI]\u2009=\u20091.00-1.76 and 1.12-3.30, respectively). The rs873601 G\/A SNP was not associated with susceptibility to GCA.\n                    <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    Our findings indicate that the rs751402 C\/T SNP has potential as a predictive marker for the risk of GCA and that carriers of the T\/T genotype should receive periodic upper gastrointestinal fiber tests to facilitate the early detection and early treatment of GCA.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2015.0333","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T16:12:38Z","timestamp":1464279158000},"page":"432-437","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>XPG<\/i>\n                    Gene Polymorphisms and the Risk of Gastric Cardia Adenocarcinoma"],"prefix":"10.1177","volume":"20","author":[{"given":"Rong-Miao","family":"Zhou","sequence":"first","affiliation":[{"name":"The Fourth Hospital of Hebei Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Xu","family":"Niu","sequence":"additional","affiliation":[{"name":"Shijiazhuang Ping'an Hospital","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"The Fourth Hospital of Hebei Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Liu","sequence":"additional","affiliation":[{"name":"The Fourth Hospital of Hebei Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Huang","sequence":"additional","affiliation":[{"name":"The Fourth Hospital of Hebei Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"The Fourth Hospital of Hebei Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Ran","family":"Huo","sequence":"additional","affiliation":[{"name":"The Fourth Hospital of Hebei Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Li","family":"Hao","sequence":"additional","affiliation":[{"name":"The Fourth Hospital of Hebei Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"The Fourth Hospital of Hebei Medical University","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,5,26]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/27.4.979"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti473"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.8.14.8889"},{"key":"e_1_3_3_5_1","unstructured":"Chen JF (2009) Detection and Functional Analysis of SNPs in the ERCC5 Promoter in Patients with Advanced Colorectal Cancer Treated with Platinum-Based Chemotherapy. 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