{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T05:41:01Z","timestamp":1779255661583,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T00:00:00Z","timestamp":1475193600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2016,12,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Aims:<\/jats:italic>\n                    No recommendations currently exist regarding implementation of both prenatal diagnosis and preimplantation genetic diagnosis (PGD) for autosomal dominant polycystic kidney disease (ADPKD). This study evaluated attitudes in ADPKD patients with either chronic kidney disease (CKD) stages I-IV or end-stage renal failure (ESRF) toward prenatal diagnosis and PGD.\n                    <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    Ninety-six ADPKD patients were recruited from an outpatient clinic, wards, and dialysis units. Thirty-eight patients had ESRF and 58 had CKD stages I-IV. Participants were given an information sheet on prenatal diagnosis and PGD and subsequently completed a questionnaire.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    The median age of participants was 51.5 years. Seventeen percent of ADPKD patients with CKD and 18% of ADPKD patients with ESRF would consider prenatal diagnosis and termination of pregnancy for ADPKD. Fifty percent with CKD would have opted for PGD (or might consider it in the future) were it available and funded by the UK National Health Service, compared to 63% in the ESRF group (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.33). Sixty-nine percent in the CKD group and 68% in the ESRF group believed that PGD should be offered to other patients.\n                    <jats:italic toggle=\"yes\">Discussion:<\/jats:italic>\n                    There was a spectrum of attitudes among this cohort. A proportion of patients believe that PGD should be made available to prospective parents with this disease. The discrepancy between the low proportion (17% CKD, 18% ESRF) who would consider prenatal diagnosis and termination of pregnancy and the higher number who hypothetically express an intention or wish to access PGD (50% CKD and 63% ESRF) indicates far greater acceptability for diagnostic methods that occur before embryo implantation. It is not known how the development of methods to identify patients whose renal function is likely to decline rapidly and treatments altering the natural history of ADPKD will affect these attitudes.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2016.0050","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T15:19:06Z","timestamp":1475248746000},"page":"741-746","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Attitudes in Patients with Autosomal Dominant Polycystic Kidney Disease Toward Prenatal Diagnosis and Preimplantation Genetic Diagnosis"],"prefix":"10.1177","volume":"20","author":[{"given":"Oscar","family":"Swift","sequence":"first","affiliation":[{"name":"East and North Hertfordshire NHS Trust","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enric","family":"Vilar","sequence":"additional","affiliation":[{"name":"East and North Hertfordshire NHS Trust","place":["United Kingdom"]},{"name":"University of Hertfordshire","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belinda","family":"Rahman","sequence":"additional","affiliation":[{"name":"University College London","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy","family":"Side","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Gale","sequence":"additional","affiliation":[{"name":"University College London","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,9,30]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00921.x"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.154"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012070650"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gah128"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.1.233"},{"key":"e_1_3_3_7_1","unstructured":"Genetic Alliance UK (2015) Preimplantation genetic diagnosis (PGD) patient information. Available at: www.geneticalliance.org.uk\/aboutpgd.htm#Question6 (Last accessed June14 2015)."},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804458"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.18"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)03495-3"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.27.9.552"},{"key":"e_1_3_3_12_1","unstructured":"Human Fertilisation and Embryology Authority (2015) PGD conditions licensed by the HFEA. Available at: http:\/\/guide.hfea.gov.uk\/pgd (Last accessed June14 2015)."},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1755738015585160"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2011.27"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem055"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs551"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-013-9685-0"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011101032"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16209-0"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320350413"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205511"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.128"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60601-1"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022161"}],"container-title":["Genetic Testing and Molecular Biomarkers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/gtmb.2016.0050","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/gtmb.2016.0050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/gtmb.2016.0050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:03:14Z","timestamp":1779192194000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/gtmb.2016.0050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,30]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12,1]]}},"alternative-id":["10.1089\/gtmb.2016.0050"],"URL":"https:\/\/doi.org\/10.1089\/gtmb.2016.0050","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726788441.793555202","asserted-by":"object"}]},"ISSN":["1945-0265","1945-0257"],"issn-type":[{"value":"1945-0265","type":"print"},{"value":"1945-0257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,30]]}}}