{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:51:20Z","timestamp":1780581080447,"version":"3.54.1"},"reference-count":51,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T00:00:00Z","timestamp":1467936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Aims:<\/jats:italic>\n                    To investigate the clinical and genetic risk factors associated with hepatocellular carcinoma (HCC) in cirrhotic patients with chronic hepatitis B (CHB).\n                    <jats:italic toggle=\"yes\">Methods:<\/jats:italic>\n                    Nine hundred forty-nine Chinese Han patients with CHB were studied, including noncirrhotic patients without HCC (\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    \u2009=\u2009234), cirrhotic patients without (\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    \u2009=\u2009281) and with HCC (\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    \u2009=\u2009434). Patients were genotyped for 10 candidate single nucleotide polymorphisms (SNPs) by the polymerase chain reaction (PCR)-ligase detection reaction (LDR) method.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    By multivariate logistic regression analysis adjusted for Child-Pugh scores, noneffective antiviral treatment, drinking history, family history of HCC, and age \u226550 years old were associated with HCC risk (odds ratio [OR]\u2009=\u20095.923, 2.456, 2.241, 1.955, respectively). Sixty-two of 170 cirrhotic patients who achieved sustained virological suppression by antiviral treatment developed HCC, with fatty liver disease, family history of HCC, and family history of hepatitis B virus (HBV) infection as the risk factors (OR\u2009=\u200911.646, 3.339, 2.537, respectively). The SNPs associated with HCC risk in patients with cirrhosis and CHB were rs11536889 in\n                    <jats:italic toggle=\"yes\">TLR4<\/jats:italic>\n                    and rs2853744 in\n                    <jats:italic toggle=\"yes\">SPP1<\/jats:italic>\n                    . Polymorphisms of\n                    <jats:italic toggle=\"yes\">TLR4<\/jats:italic>\n                    rs2149356,\n                    <jats:italic toggle=\"yes\">AP3S2<\/jats:italic>\n                    rs2290351,\n                    <jats:italic toggle=\"yes\">STXBP5L<\/jats:italic>\n                    rs2169302,\n                    <jats:italic toggle=\"yes\">MLEC<\/jats:italic>\n                    rs7976497, and\n                    <jats:italic toggle=\"yes\">SOCS3<\/jats:italic>\n                    rs4969168 were associated with HCC risk in specific stratified analyses with gender, age, and drinking history in the cirrhotic patients.\n                    <jats:italic toggle=\"yes\">Conclusions:<\/jats:italic>\n                    Inadequate antiviral treatment, family history of HCC, drinking history, and age \u226550 years old are risk factors for HCC. Sustained suppression of HBV does not eliminate the risk of HCC. Specific host genetic factors may impact HCC development in Han Chinese cirrhotic patients with CHB, including SNPs in\n                    <jats:italic toggle=\"yes\">TLR4<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">SPP1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">AP3S2<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">STXBP5L<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">MLEC<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">SOCS3<\/jats:italic>\n                    , which warrant further validation in additional cohorts.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2016.0062","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T16:38:11Z","timestamp":1467995891000},"page":"535-543","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Risk Factors for Hepatocellular Carcinoma in Cirrhotic Patients with Chronic Hepatitis B"],"prefix":"10.1177","volume":"20","author":[{"given":"Yuan-Qing","family":"Zhang","sequence":"first","affiliation":[{"name":"Fu Dan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jun","family":"Peng","sequence":"additional","affiliation":[{"name":"Fu Dan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Rong","family":"Cao","sequence":"additional","affiliation":[{"name":"Fu Dan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ping","family":"Zeng","sequence":"additional","affiliation":[{"name":"Fu Dan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"Fu Dan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Shi","sequence":"additional","affiliation":[{"name":"Fu Dan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Yao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Fu Dan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Yao","family":"Wang","sequence":"additional","affiliation":[{"name":"Fu Dan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott L.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Sninsky","sequence":"additional","affiliation":[{"name":"Celera Corporation, Alameda, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Sheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Fu Dan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,7,8]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335606"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-101724"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/76048"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002323"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.575985"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2014.08.007"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24199"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00058"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2014.06.001"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000018"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32834c3e74"},{"key":"e_1_3_3_13_1","first-page":"315","article-title":"Genetic studies to identify hepatic fibrosis genes and SNPs in human populations","volume":"2117","author":"Day CP","year":"2005","unstructured":"Day CP (2005) Genetic studies to identify hepatic fibrosis genes and SNPs in human populations. 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