{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T09:14:29Z","timestamp":1782638069745,"version":"3.54.5"},"reference-count":24,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T00:00:00Z","timestamp":1471219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Aims:<\/jats:italic>\n                    To investigate whether single nucleotide polymorphism (SNP) rs4986791 (C&gt;T) in the\n                    <jats:italic toggle=\"yes\">toll-like receptor 4<\/jats:italic>\n                    (\n                    <jats:italic toggle=\"yes\">TLR4<\/jats:italic>\n                    ) gene is a risk factor for primary open-angle glaucoma (POAG) in the Saudi population.\n                    <jats:italic toggle=\"yes\">Method:<\/jats:italic>\n                    A case-control study was performed to genotype a cohort of 85 POAG patients and 95 matched healthy controls utilizing TaqMan\n                    <jats:sup>\u00ae<\/jats:sup>\n                    . The association between mutant genotypes and various POAG clinical indices were investigated.\n                    <jats:italic toggle=\"yes\">Results:<\/jats:italic>\n                    The wild-type (C\/C), heterozygous (C\/T), and homozygous (T\/T) genotypes were observed in 85.9%, 12.9%, and 1.2% POAG cases, respectively, compared to 91.6%, 8.4%, and none, respectively, among controls. The minor allele frequency was 0.076 in cases and 0.042 in controls. Both the genotype and allele frequency among POAG cases and controls did not vary significantly. With the exception of family history of glaucoma (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.032), no significant association of genotypes was seen with age, intraocular pressure, cup\/disc ratio, number of antiglaucoma medications, and other systemic comorbidities among the POAG cases.\n                    <jats:italic toggle=\"yes\">Conclusion:<\/jats:italic>\n                    We did not detect any direct association between genotypes or allele frequencies of SNP rs4986791 in the\n                    <jats:italic toggle=\"yes\">TLR4<\/jats:italic>\n                    gene and POAG.\n                  <\/jats:p>","DOI":"10.1089\/gtmb.2016.0095","type":"journal-article","created":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T14:35:59Z","timestamp":1471271759000},"page":"556-559","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Lack of Association Between Polymorphism rs4986791 in\n                    <i>TLR4<\/i>\n                    and Primary Open-Angle Glaucoma in a Saudi Cohort"],"prefix":"10.1177","volume":"20","author":[{"given":"Ahmed","family":"Mousa","sequence":"first","affiliation":[{"name":"King Saud University","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Altaf A.","family":"Kondkar","sequence":"additional","affiliation":[{"name":"King Saud University","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh A.","family":"Al-Obeidan","sequence":"additional","affiliation":[{"name":"King Saud University","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taif A.","family":"Azad","sequence":"additional","affiliation":[{"name":"King Saud University","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahira","family":"Sultan","sequence":"additional","affiliation":[{"name":"King Saud University","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Essam A.","family":"Osman","sequence":"additional","affiliation":[{"name":"King Saud University","place":["Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled K.","family":"Abu-Amero","sequence":"additional","affiliation":[{"name":"King Saud University","place":["Saudi Arabia"]},{"name":"College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,8,15]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/13816810.2013.796390"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/90609"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(99)00045-X"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.603431"},{"key":"e_1_3_3_6_1","first-page":"629","article-title":"SNP rs1533428 at 2p16.3 as a marker for late-onset primary open-angle glaucoma","volume":"18","author":"Chen LJ","year":"2012","unstructured":"Chen LJ, , Tam PO, , Leung DY, et al. 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