{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T19:28:53Z","timestamp":1783970933556,"version":"3.55.0"},"reference-count":58,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"\n Background and Aims:<\/jats:title>\n \n The prognostic value of BRCA1-associated protein 1 (\n BAP1<\/jats:italic>\n ) expression in different cancer types remains controversial. The aim of this study was to identify the prognostic and clinicopathological significance of\n BAP1<\/jats:italic>\n gene expression.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n The PubMed, Web of Science, and Embase databases were searched comprehensively for relevant studies. The pooled effects were calculated to investigate the association of\n BAP1<\/jats:italic>\n expression with cancer prognosis and clinicopathological features. The\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n and\n I<\/jats:italic>\n 2<\/jats:sup>\n tests were performed to evaluate heterogeneity among the enrolled articles. If the\n p<\/jats:italic>\n \u2009>\u20090.05 and\n I<\/jats:italic>\n 2<\/jats:sup>\n < 50%, a fixed-effects model was applied; and if the\n p<\/jats:italic>\n \u2009<\u20090.05 and\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009>\u200950%, we used a random-effects model.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A total of 26 studies covering 8043 patients were included in the meta-analysis. The correlation between\n BAP1<\/jats:italic>\n expression and patient survival was evaluated for 10 different cancer types. The pooled hazard ratio (HR) of\n BAP1<\/jats:italic>\n expression and overall survival (OS) was 0.83 (95% confidence interval [CI]: 0.61-1.12) with heterogeneity (\n I<\/jats:italic>\n 2<\/jats:sup>\n \u2009=\u200985.8%,\n p<\/jats:italic>\n \u2009<\u20090.001), which indicated that the expression of\n BAP1<\/jats:italic>\n had no obvious impact on patient survival in the all-cancer cohort. However, subgroup analyses indicated that cancer type, rather than other parameters (geographic region, detection method, sample size, or comparison method), lead to this heterogeneity.\n BAP1<\/jats:italic>\n expression was a favorable predicative factor for OS in clear cell renal cell carcinoma (HR\u2009=\u20090.57, 95% CI: 0.47-0.69), non-small cell lung cancer (HR\u2009=\u20090.55, 95% CI: 0.32-0.96), and uveal melanoma (HR\u2009=\u20090.41, 95% CI: 0.27-0.62), while high expression of\n BAP1<\/jats:italic>\n was associated with poorer outcome in malignant pleural mesothelioma (HR\u2009=\u20092.03, 95% CI: 1.67-2.47).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Our study revealed that\n BAP1<\/jats:italic>\n expression tends to have different prognostic values in different cancer types. Clinically,\n BAP1<\/jats:italic>\n may serve as a promising marker for prognostic prediction for certain cancer types.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/gtmb.2017.0176","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T16:27:58Z","timestamp":1513873678000},"page":"115-126","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Prognostic and Clinicopathological Significance of\n BAP1<\/i>\n Protein Expression in Different Types of Cancer\u2014A Meta-Analysis"],"prefix":"10.1177","volume":"22","author":[{"given":"Zheng","family":"Wang","sequence":"first","affiliation":[{"name":"Fudan University","place":["China"]},{"name":"Fudan University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Fudan University","place":["China"]},{"name":"Fudan 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