{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:10:50Z","timestamp":1787008250456,"version":"build-2736575974"},"reference-count":45,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      We conducted a meta-analysis to investigate the associations of\n                      <jats:italic toggle=\"yes\">methionine synthase<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">MTR<\/jats:italic>\n                      ) A2756G,\n                      <jats:italic toggle=\"yes\">methionine synthase reductase<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">MTRR<\/jats:italic>\n                      ) A66G, and\n                      <jats:italic toggle=\"yes\">transcobalamin 2<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">TCN2<\/jats:italic>\n                      ) C776G gene polymorphisms with nonsyndromic cleft lip with or without cleft palate (NSCL\/P).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      The PubMed, Web of Science, Embase, and Wiley Online Library databases and the China Biomedical Literature Service System (SinoMed) were searched for relevant articles to explore the associations between the\n                      <jats:italic toggle=\"yes\">MTR<\/jats:italic>\n                      A2756G,\n                      <jats:italic toggle=\"yes\">MTRR<\/jats:italic>\n                      A66G, and\n                      <jats:italic toggle=\"yes\">TCN2<\/jats:italic>\n                      C776G polymorphisms and the risk of NSCL\/P. We performed overall comparisons and stratified analyses according to the ethnicity, type of NSCL\/P, and Hardy-Weinberg equilibrium (HWE) of the control group. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were applied to estimate the associations of these gene polymorphisms with NSCL\/P risk using fixed-effects or random-effects models incorporating five genetic models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Ultimately, 12 articles were included in this study. The pooled results did not reveal a significant association of the\n                      <jats:italic toggle=\"yes\">MTR<\/jats:italic>\n                      A2756G polymorphism with NSCL\/P risk (G vs. A: OR\u2009=\u20090.95, 95% CI\u2009=\u20090.82-1.11,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.55). Similar results were observed for the\n                      <jats:italic toggle=\"yes\">MTRR<\/jats:italic>\n                      A66G polymorphism (G vs. A: OR\u2009=\u20090.99, 95% CI\u2009=\u20090.82-1.18,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.72) and the\n                      <jats:italic toggle=\"yes\">TCN2<\/jats:italic>\n                      C776G polymorphism (G vs. C: OR\u2009=\u20090.95, 95% CI\u2009=\u20090.86-1.06,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.37).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      In summary, the\n                      <jats:italic toggle=\"yes\">MTR<\/jats:italic>\n                      A2756G,\n                      <jats:italic toggle=\"yes\">MTRR<\/jats:italic>\n                      A66G, and\n                      <jats:italic toggle=\"yes\">TCN2<\/jats:italic>\n                      C776G polymorphisms might not be associated with NSCL\/P risk.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/gtmb.2018.0037","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T11:34:30Z","timestamp":1531481670000},"page":"465-473","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Associations Between\n                    <i>MTR<\/i>\n                    A2756G,\n                    <i>MTRR<\/i>\n                    A66G, and\n                    <i>TCN2<\/i>\n                    C776G Polymorphisms and Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate: A Meta-Analysis"],"prefix":"10.1177","volume":"22","author":[{"given":"Wei","family":"Lei","sequence":"first","affiliation":[{"name":"Stomatological Hospital of Chongqing Medical University","place":["China"]},{"name":"Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences","place":["China"]},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinlan","family":"Xia","sequence":"additional","affiliation":[{"name":"Stomatological Hospital of Chongqing Medical University","place":["China"]},{"name":"Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences","place":["China"]},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wu","sequence":"additional","affiliation":[{"name":"Stomatological Hospital of Chongqing Medical University","place":["China"]},{"name":"Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences","place":["China"]},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Fu","sequence":"additional","affiliation":[{"name":"Stomatological Hospital of Chongqing Medical University","place":["China"]},{"name":"Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences","place":["China"]},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishu","family":"Ren","sequence":"additional","affiliation":[{"name":"Stomatological Hospital of Chongqing Medical University","place":["China"]},{"name":"Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences","place":["China"]},{"name":"Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,7,13]]},"reference":[{"key":"e_1_3_4_2_1","first-page":"115","article-title":"Prevalence of MTHFR, MTR and MTRR gene polymorphisms in Turkish patients with nonsyndromic cleft lip and palate","volume":"16","author":"A\u015flar D","year":"2014","unstructured":"A\u015flar D, , Hakk\u0131 T (2014) Prevalence of MTHFR, MTR and MTRR gene polymorphisms in Turkish patients with nonsyndromic cleft lip and palate. Gene Ther Mol Biol, 16:115-129.","journal-title":"Gene Ther Mol Biol"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20315"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12292"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.01.007"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2006005000112"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089609"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/48.3.407"},{"key":"e_1_3_4_9_1","first-page":"3628","article-title":"Human methionine synthase","volume":"272","author":"Chen LH","year":"1997","unstructured":"Chen LH, , Liu ML, Hwang HY et al. (1997) Human methionine synthase. cDNA cloning, gene localization, and expression. J Biol Chem, 272:3628-3634.","journal-title":"cDNA cloning, gene localization, and expression. J Biol Chem"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/26.1.7"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1415-47572013005000035"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2006.048041"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084715"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-011-0802-6"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/78.1.131"},{"key":"e_1_3_4_16_1","first-page":"4","article-title":"Association of TCN2 gene with non-syndromic cleft lip with or without cleft palate","volume":"19","author":"Hu Y","year":"2011","unstructured":"Hu Y, , Chen EJ, , Chen RJ, et al. (2011) Association of TCN2 gene with non-syndromic cleft lip with or without cleft palate. Beijing J Stomatol, 19:4-7.","journal-title":"Beijing J Stomatol"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01810.x"},{"key":"e_1_3_4_18_1","first-page":"136","article-title":"The Association between folate pathway genes and cleft lip with or without cleft palate in a Chinese population","volume":"28","author":"Jin LL","year":"2015","unstructured":"Jin LL, , Chen EJ, , Hou W, et al. (2015) The Association between folate pathway genes and cleft lip with or without cleft palate in a Chinese population. Biomed Environ Sci, 28:136-139.","journal-title":"Biomed Environ Sci"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.12.1867"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.6.3059"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/5.12.1851"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.07.007"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9411"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60695-4"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337464"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2006.00618.x"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.070029"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoms.2015.04.008"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.4.1092"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103707200"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35503"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-0159"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1597\/1545-1569_2002_039_0327_fatfet_2.0.co_2"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0398-7620(05)84617-6"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-6440201300394"},{"key":"e_1_3_4_36_1","first-page":"88","article-title":"Association between Rs1805087 polymorphisms of MTR gene and non-syndromic cleft lip with or without cleft palate","volume":"19","author":"Wang JB","year":"2011","unstructured":"Wang JB, , Nan XR (2011) Association between Rs1805087 polymorphisms of MTR gene and non-syndromic cleft lip with or without cleft palate. Beijing J Stomatol, 19:88-91.","journal-title":"Beijing J Stomatol"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2015.0186"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-12-184"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2009.01587.x"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.1999.2879"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199911)60:5<253::AID-TERA4>3.0.CO;2-V"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.22885"},{"key":"e_1_3_4_43_1","first-page":"248","article-title":"Association between polymorphism of MTR rs1805087 locus and nonsyndromic cleft lip with or without cleft palate","volume":"23","author":"Yuan GH","year":"2013","unstructured":"Yuan GH, , Nan XR (2013) Association between polymorphism of MTR rs1805087 locus and nonsyndromic cleft lip with or without cleft palate. J Oral Maxillofac Surg, 23:248-252.","journal-title":"J Oral Maxillofac Surg"},{"key":"e_1_3_4_44_1","first-page":"107","article-title":"Genetic causes of nonsyndromic cleft lip with or without cleft palate","volume":"70","author":"Yuan Q","year":"2011","unstructured":"Yuan Q, , Blanton SH, , Hecht JT (2011) Genetic causes of nonsyndromic cleft lip with or without cleft palate. Adv Otorhinolaryngol, 70:107-113.","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059570"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088242"}],"container-title":["Genetic Testing and Molecular Biomarkers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/gtmb.2018.0037","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/gtmb.2018.0037","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/gtmb.2018.0037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:21:44Z","timestamp":1777447304000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/gtmb.2018.0037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,13]]},"references-count":45,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1089\/gtmb.2018.0037"],"URL":"https:\/\/doi.org\/10.1089\/gtmb.2018.0037","relation":{},"ISSN":["1945-0265","1945-0257"],"issn-type":[{"value":"1945-0265","type":"print"},{"value":"1945-0257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,13]]}}}