{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:30:48Z","timestamp":1777660248378,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To correlate differences in estradiol levels in serum and follicular fluid with genetic variants and to determine if they play a role in the results following assisted reproductive technology (ART).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>\n                      A cross-sectional study was developed at the Ideia F\u00e9rtil Institute of Reproductive Health. Two hundred two female patients were selected and underwent controlled ovarian hyperstimulation cycles. Patients for this study were chosen based on their male partners' infertility. Genotypes of selected variants of\n                      <jats:italic toggle=\"yes\">CYP19A1<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">CYP17A1<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">HSD17<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">COMT<\/jats:italic>\n                      were compared to the estradiol measurements from follicular fluid and serum, as well as to the number and maturation status of the oocytes retrieved.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Patients with the variant homozygous genotype AA of\n                      <jats:italic toggle=\"yes\">CYP19A1<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">rs10046<\/jats:italic>\n                      ) showed increased serum concentrations of estradiol when compared to patients with other genotypes (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.005). The same polymorphism effect was not observed in follicular fluid. This\n                      <jats:italic toggle=\"yes\">CYP19A1<\/jats:italic>\n                      variant did not affect the number of oocytes recovered nor their maturation level.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic toggle=\"yes\">CYP19A1<\/jats:italic>\n                      variant is associated with an estradiol imbalance in serum. Other pathways, however, may contribute to the formation of the final estradiol metabolite in follicular fluid as well as its impact on the oocyte maturation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/gtmb.2018.0205","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T11:34:31Z","timestamp":1548675271000},"page":"145-149","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["The Impact of Variants in Genes Associated with Estradiol Synthesis on Hormone Levels and Oocyte Retrieval in Patients Who Underwent Controlled Ovarian Hyperstimulation"],"prefix":"10.1177","volume":"23","author":[{"given":"Aline","family":"Amaro","sequence":"first","affiliation":[{"name":"Institute Ideia F\u00e9rtil of Reproductive Health, Santo Andr\u00e9, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Poler\u00e1","sequence":"additional","affiliation":[{"name":"Institute Ideia F\u00e9rtil of Reproductive Health, Santo Andr\u00e9, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Winter dos Santos","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Collective Health Department, Reproductive Health and Population Genetics Discipline, Faculdade de Medicina do ABC, Santo Andr\u00e9, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Bianco","sequence":"additional","affiliation":[{"name":"Institute Ideia F\u00e9rtil of Reproductive Health, Santo Andr\u00e9, Brazil."},{"name":"Collective Health Department, Reproductive Health and Population Genetics Discipline, Faculdade de Medicina do ABC, Santo Andr\u00e9, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise Maria","family":"Christofolini","sequence":"additional","affiliation":[{"name":"Institute Ideia F\u00e9rtil of Reproductive Health, Santo Andr\u00e9, Brazil."},{"name":"Collective Health Department, Reproductive Health and Population Genetics Discipline, Faculdade de Medicina do ABC, Santo Andr\u00e9, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caio Parente","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Institute Ideia F\u00e9rtil of Reproductive Health, Santo Andr\u00e9, Brazil."},{"name":"Collective Health Department, Reproductive Health and Population Genetics Discipline, Faculdade de Medicina do ABC, Santo Andr\u00e9, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,2,8]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60009-0"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-2215-7-11"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-7-123"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-07-0276"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp048"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD01071"},{"key":"e_1_3_3_8_1","first-page":"1015","article-title":"The relationship between a variant in CYP17 with plasma hormone levels and breast cancer","volume":"59","author":"Haiman C A","year":"1999","unstructured":"Haiman C A, , Hankinson S E, , Spiegelman D, et al. 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