{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:31:01Z","timestamp":1777660261481,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study was conducted to determine if single nucleotide polymorphisms within the interleukin (IL)-13 (rs20541 locus), the S100B (rs9722 locus), and the toll-like receptor (TLR)-7 (rs179019 and rs3853839 loci) genes are associated with the clinical severity of disease caused by enterovirus 71 (EV71) in children suffering from hand, foot, and mouth disease (HFMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 355 children, diagnosed with HFMD, were divided into two groups: severe (totaling 162 cases) and mild (totaling 193 cases). Three hundred healthy children were recruited as a control group. The gene polymorphisms of the rs20541 locus in the\n                      <jats:italic toggle=\"yes\">IL-13<\/jats:italic>\n                      gene; the rs9722 locus in the\n                      <jats:italic toggle=\"yes\">S100B<\/jats:italic>\n                      gene; and the rs179019 and the rs3853839 loci in the\n                      <jats:italic toggle=\"yes\">TLR-7<\/jats:italic>\n                      gene were analyzed with Sanger sequencing. The expression levels of IL-13, S100B, interferon (IFN)-\u03b1, IL-6 and the relative expression level of TLR-7 were calculated for each genotype.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      This study demonstrated that the T allele at the rs9722 locus of the S100B gene was a significant risk factor for severe HFMD. The rs3853839 C allele of the\n                      <jats:italic toggle=\"yes\">TLR-7<\/jats:italic>\n                      gene was also a risk factor for severe HFMD in both male and female patients. The G allele at the rs20541 locus of\n                      <jats:italic toggle=\"yes\">IL-13<\/jats:italic>\n                      gene and the A allele at the rs179019 locus of the\n                      <jats:italic toggle=\"yes\">TLR-7<\/jats:italic>\n                      gene were not risk factors for severe HFMD in either male or female patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The T allele at the rs9722 locus of\n                      <jats:italic toggle=\"yes\">S100B<\/jats:italic>\n                      gene is a risk factor for the severe HFMD caused by EV71 infection, of which the mechanism may be due to the promotion of S100B protein secretion. The allele C at\n                      <jats:italic toggle=\"yes\">TLR-7<\/jats:italic>\n                      rs3853839 locus is a risk factor for the severe HFMD caused by EV71 infection, which may be related to a reduction of the relative expression of TLR-7, IFN-\u03b1, and IL-6.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/gtmb.2018.0239","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T12:36:38Z","timestamp":1551184598000},"page":"188-196","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of\n                    <i>IL-13<\/i>\n                    ,\n                    <i>S100B<\/i>\n                    , and\n                    <i>TLR-7<\/i>\n                    Gene Polymorphisms with Enterovirus 71 Infection in Hand, Foot, and Mouth Disease in China"],"prefix":"10.1177","volume":"23","author":[{"given":"Yuhong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Dongying People's Hospital, Dongying, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Suo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Dongying People's Hospital, Dongying, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hyperbaric Oxygenation, Dongying People's Hospital, Dongying, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,3,15]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000456009"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127999"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-007-0008-x"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000314366"},{"key":"e_1_3_2_6_1","first-page":"588","article-title":"Analysis of the epidemiological characteristics of hand-foot-and-mouth disease in Anhui Province between 2008 and 2014","author":"Chen GP","year":"2016","unstructured":"Chen GP, , Shi YL, , Zhang J, et al. 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