{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:57:34Z","timestamp":1778565454997,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Hallux valgus (HV) is a type of forefoot deformity affecting \u223c23% of adults. Previous studies have shown that HV is highly heritable. Tumor necrosis factor (\n                      <jats:italic toggle=\"yes\">TNF<\/jats:italic>\n                      ) is an important proinflammatory cytokine involved in bone remodeling and plays essential roles in osteoarthritis and chronic inflammatory bone diseases, including HV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 1,788 Chinese women comprising 637 HV subjects and 1,151 controls were recruited. Twelve single nucleotide polymorphisms (SNPs) located in\n                      <jats:italic toggle=\"yes\">TNF<\/jats:italic>\n                      and its promoter regions were selected and genotyped. Genetic association analyses were performed to investigate potential susceptibility SNPs. Bioinformatic and expression quantitative trait loci (eQTL) analyses were conducted to examine the functional consequences of the SNPs identified as being significantly associated with HV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      SNP rs1800629, which is located at the 5\u2032 end of the promoter region of\n                      <jats:italic toggle=\"yes\">TNF<\/jats:italic>\n                      , was identified as significantly associated with HV status in Chinese women (OR\u2009=\u20090.56,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20092.12\u2009\u00d7\u200910\n                      <jats:sup>\u22126<\/jats:sup>\n                      ). Bioinformatic analyses using RegulomeDB indicated that this SNP has important functional significance, but subsequent eQTL analyses did not identify a significant association between rs1800629 and TNF gene expression. In addition, 26 genes with cis-eQTL for rs1800629 were identified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      This study identified a susceptibility SNP for HV located within the promoter region of the\n                      <jats:italic toggle=\"yes\">TNF<\/jats:italic>\n                      gene. Bioinformatic and eQTL analyses linked this SNP to 26 genes but not to\n                      <jats:italic toggle=\"yes\">TNF<\/jats:italic>\n                      . Functional studies are needed to more fully characterize the effects of this SNP.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/gtmb.2018.0269","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T15:02:43Z","timestamp":1557241363000},"page":"380-386","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Relationship Between Genetic Polymorphisms of the\n                    <i>TNF<\/i>\n                    Gene and Hallux Valgus Susceptibility"],"prefix":"10.1177","volume":"23","author":[{"given":"Jie","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Foot and Ankle Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Foot and Ankle Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Foot and Ankle Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmou","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Foot and Ankle Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Foot and Ankle Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Foot and Ankle Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Foot and Ankle Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,5,30]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.10.1533"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.11.020"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2015.66"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2653"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22391"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-009-0872-0"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep12935"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep29586"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.03.030"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.01.025"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2013.11.004"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-011-1120-8"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2016.07.004"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep38048"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24914"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.4132\/KoreanJPathol.2012.46.1.30"},{"key":"e_1_3_4_19_1","first-page":"30613","article-title":"Relationship of common variants in CHRNA5 with early-onset schizophrenia and executive function","volume":"0920","author":"Han W","year":"2018","unstructured":"Han W, , Zhang TX, , Ni T, et al. 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