{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:34:13Z","timestamp":1777660453496,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>\n                      This study investigated the presence of human papillomavirus (HPV) infection and the methylation status of the promoters of the cell adhesion molecule 1 (\n                      <jats:italic toggle=\"yes\">CADM1<\/jats:italic>\n                      ) gene and T lymphocyte maturation associated protein (\n                      <jats:italic toggle=\"yes\">MAL<\/jats:italic>\n                      ) gene in patients with cervicitis\/inflammation and cervical intraepithelial neoplasia (CIN).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Cervical specimens (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200947) were collected from women with normal cervical cytology (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200921) and those with cervical abnormalities (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200926). The presence of HPV infection was confirmed by an HPV DNA test and an HPV mRNA test (Aptima HPV test). Methylation levels of the\n                      <jats:italic toggle=\"yes\">CADM1<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">MAL<\/jats:italic>\n                      promoters were evaluated by pyrosequencing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Compared with the HPV DNA test, the Aptima HPV test improved specificity from 57% to 70% for the detection of inflammation and\/or CIN type 1 (CIN1) or more advanced conditions (CIN1+). The methylation level of the\n                      <jats:italic toggle=\"yes\">CADM1<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">MAL<\/jats:italic>\n                      promoters was 1.5 times higher in inflammatory samples, compared with normal cervical cytology (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Selected 5\u2032-C-phosphate-G-3\u2032 islands within the promoters of the\n                      <jats:italic toggle=\"yes\">CADM1<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">MAL<\/jats:italic>\n                      genes were differentially methylated in the inflammatory samples compared with the CIN samples. These results suggested that methylation likely occurred following tissue disruption, and the detection of persistent inflammation might be associated with a higher risk of lesion progression.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/gtmb.2019.0188","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T17:07:11Z","timestamp":1587402431000},"page":"256-263","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["The Role of\n                    <i>CADM1<\/i>\n                    and\n                    <i>MAL<\/i>\n                    Promoter Methylation in Inflammation and Cervical Intraepithelial Neoplasia"],"prefix":"10.1177","volume":"24","author":[{"given":"Veronika","family":"Holubekova","sequence":"first","affiliation":[{"name":"Division of Oncology, Jessenius Faculty of Medicine, Biomedical Center Martin, Comenius University in Bratislava, Martin, Slovakia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Mersakova","sequence":"additional","affiliation":[{"name":"Division of Oncology, Jessenius Faculty of Medicine, Biomedical Center Martin, Comenius University in Bratislava, Martin, Slovakia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Grendar","sequence":"additional","affiliation":[{"name":"Bioinformatic Unit, Jessenius Faculty of Medicine, Biomedical Center Martin, Comenius University in Bratislava, Martin, Slovakia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuzana","family":"Snahnicanova","sequence":"additional","affiliation":[{"name":"Division of Oncology, Jessenius Faculty of Medicine, Biomedical Center Martin, Comenius University in Bratislava, Martin, Slovakia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Kudela","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin University Hospital, Martin, Slovakia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Kalman","sequence":"additional","affiliation":[{"name":"Department of Pathological Anatomy, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin University Hospital, Martin, Slovakia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zora","family":"Lasabova","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genomics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Danko","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin University Hospital, Martin, Slovakia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavol","family":"Zubor","sequence":"additional","affiliation":[{"name":"Division of Oncology, Jessenius Faculty of Medicine, Biomedical Center Martin, Comenius University in Bratislava, Martin, Slovakia."},{"name":"Department of Obstetrics and Gynaecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin University Hospital, Martin, 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