{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:38:39Z","timestamp":1790152719351,"version":"4.0.1"},"reference-count":46,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim of this study was to explore the possible associations between single nucleotide polymorphisms (SNPs) and DNA methylation levels of seven genes in the inflammatory response pathway with susceptibility to chronic periodontitis (CP) among the Uighur population of the Xinjiang Autonomous Region of China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 444 eligible subjects (279 CP patients and 165 healthy controls) were enrolled in the study. Genomic DNA was obtained from gingival tissue for genotyping eight SNPs and performing methylation measurements of seven genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      SNP\n                      <jats:italic toggle=\"yes\">rs2070745<\/jats:italic>\n                      in the formyl peptide receptor 1 (\n                      <jats:italic toggle=\"yes\">FPR1<\/jats:italic>\n                      ) gene achieved statistical significance in a standard allelic association analysis for CP (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.02). The frequency of the\n                      <jats:italic toggle=\"yes\">rs2070745<\/jats:italic>\n                      minor allele G was higher in the cases than in controls (0.367 vs. 0.291). Additionally,\n                      <jats:italic toggle=\"yes\">rs2070745<\/jats:italic>\n                      was significantly associated with CP under the dominant genetic model (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.03). Using logistic regression analysis,\n                      <jats:italic toggle=\"yes\">rs2070745<\/jats:italic>\n                      was found to be consistently associated with CP under the additive dominant model, and this association remained significant after covariates were taken into account [odds ratio (OR)\u2009=\u20091.49 (1.09-2.05),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.014; OR\u2009=\u20091.58 (1.04-2.40),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.031, respectively]. No significant gene-gene interactions were identified. Although we did not find a polymorphism in interleukin 6 (\n                      <jats:italic toggle=\"yes\">IL6<\/jats:italic>\n                      ) associated with CP in our study, the methylation level of a CpG island region located within the promoter region of\n                      <jats:italic toggle=\"yes\">IL6<\/jats:italic>\n                      was significantly less in CP patients compared with controls (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      The genetic polymorphism\n                      <jats:italic toggle=\"yes\">rs2070745<\/jats:italic>\n                      in\n                      <jats:italic toggle=\"yes\">FPR1<\/jats:italic>\n                      and the methylation level of the promoter region of\n                      <jats:italic toggle=\"yes\">IL6<\/jats:italic>\n                      might be associated with CP in the Uighur population of China.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/gtmb.2020.0334","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T16:19:36Z","timestamp":1620145176000},"page":"317-324","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the Genetic Association and Methylation of Immune Response Pathway Genes with the Risk of Chronic Periodontitis in the Uighur Population"],"prefix":"10.1177","volume":"25","author":[{"given":"Aisaiti","family":"Abasijiang","sequence":"first","affiliation":[{"name":"Department of Endodontics, First Affiliated Hospital of Xinjiang Medical University, and College of Stomatology of Xinjiang Medical University, Urumqi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Endodontics, First Affiliated Hospital of Xinjiang Medical University, and College of Stomatology of Xinjiang Medical University, Urumqi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endodontics, First Affiliated Hospital of Xinjiang Medical University, and College of Stomatology of Xinjiang Medical University, Urumqi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7454-4658","authenticated-orcid":false,"given":"Jin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Endodontics, First Affiliated Hospital of Xinjiang Medical University, and College of Stomatology of Xinjiang Medical University, Urumqi, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100513"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.09.022"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12002"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090510"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-014-0171-4"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.05.067"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12389"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2003.08.001"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.09.105"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.04.016"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2017.12.001"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12828"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-020-00982-7"},{"key":"e_1_3_5_15_1","first-page":"30","article-title":"The effects of oral health on systemic health","volume":"65","author":"Kane SF","year":"2017","unstructured":"Kane SF (2017) The effects of oral health on systemic health. 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