{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:39:05Z","timestamp":1777660745922,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Host genetic factors play a major role with respect to susceptibility to infections. Many polymorphisms of the Toll-like receptors (TLRs), members of the innate immune response, are directly associated with the clinical outcomes following infection. The 2848 G\/A variant (rs352140) of the\n                      <jats:italic toggle=\"yes\">TLR9<\/jats:italic>\n                      gene is associated with increased TLR9 expression. However, the impact of the genotypes of this SNP on HIV+, HCV+, and HCV+\/HIV+ individuals is still debated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      This study investigated the 2848 G\/A polymorphism in HCV infection, HIV infection, and HCV\/HIV co-infection in a large sample of Brazilians (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20091,182). Groups were initially compared without considering stratification by ethnicity and subsequently stratifying individuals between whites and non-whites.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Considering non-white individuals, a significant difference between the HIV+\/HCV+ group and controls was observed with the GG genotype serving as a protective factor (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.023). Additionally, significant allelic differences were observed between the HCV+ group and controls (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.042); between the HIV+\/HCV+ group and controls (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.011); and between the HIV+\/HCV+ group and HIV+ individuals (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.047). However, all significant results were lost following adjustment for multiple comparisons (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Although our initial results indicated a potential influence of the rs352140 genotype on host altered susceptibility to viral infections, following correction for multiple comparisions the standard (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05) for statistical association was lost. This may be due to insufficient sample size as we were examining many different associations. Thus, a larger study is warranted to further pursue this topic.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/gtmb.2021.0288","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T11:09:11Z","timestamp":1652699351000},"page":"263-269","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>TLR9<\/i>\n                    2848 G\/A Gene Polymorphism in HCV+, HIV+, and HCV+\/HIV+ Individuals"],"prefix":"10.1177","volume":"26","author":[{"given":"Bruna","family":"Kulmann-Leal","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Imunobiologia e Imunogen\u00e9tica, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Gen\u00e9tica e Biologia Molecular, Departamento de Gen\u00e9tica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel Henrique","family":"Ellwanger","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunobiologia e Imunogen\u00e9tica, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Gen\u00e9tica e Biologia Molecular, Departamento de Gen\u00e9tica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline Mar\u00eda","family":"Valverde-Villegas","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunobiologia e Imunogen\u00e9tica, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Gen\u00e9tica e Biologia Molecular, Departamento de Gen\u00e9tica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil."},{"name":"Institut de G\u00e9n\u00e9tique Mol\u00e9culaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS), Laboratoire Coop\u00e9ratif IGMM\/ABIVAX, UMR 5535, Montpellier, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Simon","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00e9tica Molecular Humana, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Guerra","family":"Marangon","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00e9tica Molecular Humana, Universidade Luterana do Brasil (ULBRA), Canoas, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Su\u00f1\u00e9","family":"Mattevi","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre (UFCSPA), Porto Alegre, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosmeri Kuhmmer","family":"Lazzaretti","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Cardiologia e Ci\u00eancias Cardiovasculares, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Kuhmmer","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Cardiologia e Ci\u00eancias Cardiovasculares, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Sprinz","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul (UFRGS), Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7025-0660","authenticated-orcid":false,"given":"Jos\u00e9 Artur Bogo","family":"Chies","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunobiologia e Imunogen\u00e9tica, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Gen\u00e9tica e Biologia Molecular, Departamento de Gen\u00e9tica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-5573-8-1"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/90609"},{"key":"e_1_3_4_4_1","unstructured":"Avert. 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