{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:40:13Z","timestamp":1777660813911,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>\n                      This study was designed to analyze the association between the\n                      <jats:italic toggle=\"yes\">SLC2A2<\/jats:italic>\n                      rs1499821 polymorphism and caries susceptibility in the Chinese Han, Zhuang, and Baikuyao populations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      The present case-control study included 1067 12-year-old children: 481 with caries (142 Han, 166 Zhuang and 173 Baikuyao) and 586 who were caries-free (135 Han, 178 Zhuang and 273 Baikuyao). Questionnaires about diet and oral habits were obtained from all subjects. All of the children received dental examinations and DNA collection. The\n                      <jats:italic toggle=\"yes\">SLC2A2<\/jats:italic>\n                      rs1499821 SNP was genotyped using the SNPscan technique.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The rs1499821 T polymorphism was significantly associated with caries susceptibility in both the Han population and the combined populations of the three ethnic subgroups.\n                      <jats:italic toggle=\"yes\">SLC2A2<\/jats:italic>\n                      rs1499821 was associated with caries susceptibility in the dominant model in the Han (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.045) population and the combined (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.038) group. The CT+TT genotypes at rs1499821 were associated with a higher risk of caries in the Han (OR\u2009=\u20091.69, adjusted 95% CI: 1.01-2.81) and combined (OR\u2009=\u20091.33, adjusted 95% CI: 1.02-1.74) populations. In both Han (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.009) and the combined populations (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.004), there were statistically significant associations between the frequency of sweet food intake and dental caries. However, the rs1499821 polymorphisms did not associate with the frequency of sweet food intake in these ethnic subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      In the Han population, the\n                      <jats:italic toggle=\"yes\">SLC2A2<\/jats:italic>\n                      rs1499821 T allele and the frequency of sweet food intake may be regarded as risk factors for caries susceptibility. The\n                      <jats:italic toggle=\"yes\">SLC2A2<\/jats:italic>\n                      rs1499821 T allele had no association with the frequency of sweet food intake in any of the three ethnic groups.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/gtmb.2022.0201","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T17:00:38Z","timestamp":1685552438000},"page":"149-156","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between the\n                    <i>SLC2A2<\/i>\n                    Gene rs1499821 Polymorphism and Caries Susceptibility"],"prefix":"10.1177","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8705-0286","authenticated-orcid":false,"given":"Li","family":"Liu","sequence":"first","affiliation":[{"name":"Guangxi Medical University College of Stomatology, Nanning, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Ma","sequence":"additional","affiliation":[{"name":"Guangxi Medical University College of Stomatology, Nanning, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiulin","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Medical University College of Stomatology, Nanning, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueting","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangxi Medical University College of Stomatology, Nanning, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Guangxi Medical University College of Stomatology, Nanning, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19084511"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508401115"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345880670111201"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.0022-0337.2001.65.10.tb03444.x"},{"issue":"18","key":"e_1_3_5_6_1","first-page":"S39","article-title":"Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: Consensus report of group 2 of the joint EFP\/ORCA workshop on the boundaries between caries and periodontal diseases","volume":"44","author":"Chapple IL","year":"2017","unstructured":"Chapple IL, , Bouchard P, , Cagetti MG, et al. 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