{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:36:06Z","timestamp":1780626966591,"version":"3.54.1"},"reference-count":48,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Apolipoprotein A5 (APOA5) is involved in serum triglyceride (TG) regulation. Several studies have reported that the rs651821 locus in the\n                      <jats:italic toggle=\"yes\">APOA5<\/jats:italic>\n                      gene is associated with serum TG levels in the Chinese population. However, no research has been performed regarding the association between the variants of rs651821 and the risk of hyperlipidemic acute pancreatitis (HLAP).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A case-control study was conducted and is reported following the STROBE guidelines. We enrolled a total of 88 participants in this study (60 HLAP patients and 28 controls).\n                      <jats:italic toggle=\"yes\">APOA5<\/jats:italic>\n                      was genotyped using PCR and Sanger sequencing. Logistic regression models were conducted to calculate odds ratios and a 95% confidence interval.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The genotype distribution of the rs651821 alleles in both groups follow the Hardy-Weinberg distribution. The frequency of the \u201cC\u201d allele in rs651821 was increased in HLAP patients compared to controls. In the recessive model, subjects with the \u201cCC\u201d genotype had an 8.217-fold higher risk for HLAP (OR\u2009=\u20098.217, 95% CI: 1.023-66.01,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.046) than subjects with the \u201cTC+TT\u201d genotypes. After adjusting for sex, the association remained significant (OR\u2009=\u20099.898, 95% CI: 1.176-83.344,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.035). Additionally, the \u201cCC\u201d genotype was related to an increased TG\/apolipoprotein B (APOB) ratio and fasting plasma glucose (FPG) levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Our findings suggest that the C allele of rs651821 in\n                      <jats:italic toggle=\"yes\">APOA5<\/jats:italic>\n                      increases the risk of HLAP in persons from Southeastern China.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/gtmb.2023.0107","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T11:03:06Z","timestamp":1695898986000},"page":"284-289","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of Apolipoprotein A5 Gene Variants with Hyperlipidemic Acute Pancreatitis in Southeastern China"],"prefix":"10.1177","volume":"27","author":[{"given":"Yingyi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hehui","family":"Cai","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yancheng","family":"Lin","sequence":"additional","affiliation":[{"name":"HI. 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