{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T21:05:24Z","timestamp":1785618324364,"version":"3.56.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We designed a prospective experiment to explore the whole promoter region of fibrinogen B \u03b2 (FGB) with the intent to detect all single nucleotide polymorphisms (SNPs) in this region and their impact on the susceptibility of aseptic lower extremity superficial thrombophlebitis (STP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The experiment was conducted prospectively and randomized. Thirty-four idiopathic STP patients and 50 healthy people were recruited, respectively, as case and control groups. The whole FGB promoter was gene sequenced.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      From upstream to downstream of the promoter, a totally 6 SNPs\u2014rs1800789 (\u22121420G\/A), rs2227389 (\u2212993C\/T), rs1800791 (\u2212854G\/A), rs1800790 (\u2212455G\/A), rs1800788 (\u2212249C\/T), and rs1800787 (\u2212148C\/T) were detected via gene sequencing. A statistical difference was found in the \u2212455A allele (rs1800790) between the two groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05, odds ratio = 0.368, 95% confidence interval: 0.093\u2009\u2212\u20090.852), while no statistical difference as for the other five SNPs (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The 455A allele may be a protective locus for the onset of STP. However, due to the low incidence of idiopathic STP, multiple verification tests are still needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/gtmb.2024.0503","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T12:50:13Z","timestamp":1747831813000},"page":"144-151","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["\u2212455A Allele May Be a Protective Locus for Aseptic Lower Extremity Superficial Thrombophlebitis"],"prefix":"10.1177","volume":"29","author":[{"given":"Ruixiang","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, the First Affiliated Hospital, Kunming Medical University, Kunming, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8355-3047","authenticated-orcid":false,"given":"Shengbin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the First Affiliated Hospital, Kunming Medical University, Kunming, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhe","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the First Affiliated Hospital, Kunming Medical University, Kunming, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the First Affiliated Hospital, Kunming Medical University, Kunming, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxi","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, the First Affiliated Hospital, Kunming Medical University, Kunming, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mbc.0000164428.13417.e2"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200403000-00005"},{"key":"e_1_3_4_4_1","volume-title":"StatPearls [Internet].","author":"Czysz A","year":"2025","unstructured":"Czysz A, , Higbee SL. Superficial Thrombophlebitis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025."},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13279"},{"issue":"2","key":"e_1_3_4_6_1","first-page":"CD004982","article-title":"Treatment for superficial thrombophlebitis of the leg","volume":"2","author":"Di Nisio M","year":"2018","unstructured":"Di Nisio M, , Wichers IM, , Middeldorp S. Treatment for superficial thrombophlebitis of the leg. 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