{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:23:31Z","timestamp":1787862211869,"version":"build-2784847793"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Genetic Testing and Molecular Biomarkers"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Rheumatoid arthritis (RA) is a chronic inflammatory disease, presenting with joint inflammation and its progressive destruction, affecting a range of about 0.24\u20131% of the population in different parts of the world. It is one of the major disabling conditions among middle-aged and older women. In this study, the association between five single nucleotide polymorphisms (SNPs) of the CTLA4 gene and RA was investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The study group included 200 patients with RA and 184 healthy individuals from the Iranian population as a control group. Results: After PCR and genotyping, 4 of the 5 SNPs studied showed a significant association with RA. Also, an association between specific haplotypes with RA was determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Based on the results, it can be said that some SNPs of the CTLA4 gene may serve as genetic markers for predicting RA susceptibility or progression and using personalized treatment, lead to improved outcomes among patients with RA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/gtmb.2025.0086","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T08:28:12Z","timestamp":1748334492000},"page":"166-171","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of\n                    <i>CTLA4<\/i>\n                    Gene Polymorphisms with Rheumatoid Arthritis Susceptibility"],"prefix":"10.1177","volume":"29","author":[{"given":"Abdullah","family":"Albahar","sequence":"first","affiliation":[{"name":"Sheikh Jaber Al Ahmed Al Jaber Al Sabah Hospital, Kuwait City, Kuwait."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Torktaz","sequence":"additional","affiliation":[{"name":"Ilya Biotech Company, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0983-8304","authenticated-orcid":false,"given":"Massoud","family":"Houshmand","sequence":"additional","affiliation":[{"name":"Department of Medical Biotechnology, National Institute for Genetic engineering and biotechnology, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"key":"e_1_3_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"e_1_3_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40575-020-0081-4"},{"key":"e_1_3_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2019.08.079"},{"key":"e_1_3_7_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.730507"},{"key":"e_1_3_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8111842"},{"key":"e_1_3_7_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1123832"},{"key":"e_1_3_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102735"},{"key":"e_1_3_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204627"},{"key":"e_1_3_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.03.016"},{"key":"e_1_3_7_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1069424"},{"issue":"3","key":"e_1_3_7_12_1","first-page":"127","article-title":"CTLA4 gene variants in autoimmunity and cancer: A comparative review","volume":"8","author":"Ghaderi A","year":"2011","unstructured":"Ghaderi A. CTLA4 gene variants in autoimmunity and cancer: A comparative review. Iranian J Immunol, 2011; 8(3):127\u2013149.","journal-title":"Iranian J Immunol"},{"key":"e_1_3_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2005.00249.x"},{"issue":"318","key":"e_1_3_7_14_1","first-page":"99","article-title":"Achievement of clinical remission in patients with rheumatoid arthritis depending on the ACCP-and RF-serological status","author":"Iaremenko O","year":"2021","unstructured":"Iaremenko O, , Mykytenko G. Achievement of clinical remission in patients with rheumatoid arthritis depending on the ACCP-and RF-serological status. Georgian Med News, 2021(318):99\u2013104.","journal-title":"Georgian Med News"},{"key":"e_1_3_7_15_1","first-page":"93","article-title":"Estimating the prevalence and disease characteristics of rheumatoid arthritis in Tehran: A WHO-ILAR COPCORD Study (from Iran COPCORD study, Urban Study stage 1)","volume":"28","author":"Jamshidi A-R","year":"2014","unstructured":"Jamshidi A-R, , Banihashemi AT, , Roknsharifi S, et al. Estimating the prevalence and disease characteristics of rheumatoid arthritis in Tehran: A WHO-ILAR COPCORD Study (from Iran COPCORD study, Urban Study stage 1). Medical Journal of the Islamic Republic Of Iran, 2014; 28:93.","journal-title":"Medical Journal of the Islamic Republic Of Iran"},{"key":"e_1_3_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15085"},{"issue":"10","key":"e_1_3_7_17_1","first-page":"978","article-title":"Single nucleotide polymorphisms","volume":"578","author":"Komar AA","year":"2009","unstructured":"Komar AA. Single nucleotide polymorphisms. Methods in Molecular Biology, 2009; 578(10):978.","journal-title":"Methods in Molecular Biology"},{"key":"e_1_3_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-012-9650-y"},{"key":"e_1_3_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.12.009"},{"key":"e_1_3_7_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.598076"},{"issue":"4","key":"e_1_3_7_21_1","article-title":"Challenges of Rheumatoid Arthritis Registry in Iran: Qualitative Content Analysis","volume":"6","author":"Mehrabi N","year":"2019","unstructured":"Mehrabi N, , Langarizadeh M, , Ahmadzadeh A. Challenges of Rheumatoid Arthritis Registry in Iran: Qualitative Content Analysis. Crescent Journal of Medical & Biological Sciences, 2019; 6(4).","journal-title":"Crescent Journal of Medical & Biological Sciences"},{"key":"e_1_3_7_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/jrms.JRMS_567_20"},{"key":"e_1_3_7_23_1","article-title":"Genetic susceptibility of cytotoxic T lymphocyte-associated antigen 4 gene polymorphism in the onset of arthritis","author":"Mukhtar M","year":"2021","unstructured":"Mukhtar M, , Sheikh N, , Suqaina SK, et al. Genetic susceptibility of cytotoxic T lymphocyte-associated antigen 4 gene polymorphism in the onset of arthritis. medRxiv, 2021.","journal-title":"medRxiv"},{"key":"e_1_3_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2017.05.010"},{"key":"e_1_3_7_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00507"},{"key":"e_1_3_7_26_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2000.580402.x"},{"key":"e_1_3_7_27_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.080770"},{"key":"e_1_3_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2017.04.003"},{"key":"e_1_3_7_29_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203349"}],"container-title":["Genetic Testing and Molecular Biomarkers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/gtmb.2025.0086","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/gtmb.2025.0086","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/gtmb.2025.0086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:21:44Z","timestamp":1777447304000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/gtmb.2025.0086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1089\/gtmb.2025.0086"],"URL":"https:\/\/doi.org\/10.1089\/gtmb.2025.0086","relation":{},"ISSN":["1945-0265","1945-0257"],"issn-type":[{"value":"1945-0265","type":"print"},{"value":"1945-0257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}