{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:47:46Z","timestamp":1777661266165,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Gynecologic Surgery"],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine quality-adjusted life years (QALYs) over 3 years after transcervical fibroid ablation (TFA) with the Sonata System.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The SONATA trial was a prospective multicenter interventional trial that assessed the safety and efficacy of TFA for treatment of women with symptomatic uterine fibroids. Change in generic health status was assessed with the EuroQol 5-Dimension questionnaire (0\u20131 scale). Fibroid-specific quality of life (QOL) was measured on a 0 to 100 scale with the health-related quality of life subscale of the Uterine Fibroid Symptom and Quality-of-Life (UFS-QOL). The number of QALYs gained relative to baseline and cumulative QALYs were calculated using the area under the curve at each follow-up visit over 3 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 147 women receiving TFA, fibroid-specific QOL increased from 40\u2009\u00b1\u200921 at baseline to 84\u2009\u00b1\u200919 at 1 year and 83\u2009\u00b1\u200923 at 3 years (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Generic QOL increased from 0.72\u2009\u00b1\u20090.21 at baseline to 0.89\u2009\u00b1\u20090.12 at 1 year and 0.88\u2009\u00b1\u20090.16 at 3 years (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Over 3 years, TFA resulted in 1.24\u2009\u00b1\u20090.64 QALYs gained when using fibroid-specific health utility scores and 0.49\u2009\u00b1\u20090.61 QALYs gained when using generic health utility scores. Cumulative QALYs experienced at 3 years as a percentage of perfect health were 82% with fibroid-specific scores and 88% with generic health scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      Women treated by TFA with the Sonata System for symptomatic uterine fibroids reported durable improvements in generic and fibroid-specific QOL, as well as clinically meaningful increases in QALYs over 3 years. Clinical\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/Trials.gov\">Trials.gov<\/jats:ext-link>\n                      ID: NCT02228174. (J GYNECOL SURG 38:143)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/gyn.2021.0073","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T17:11:49Z","timestamp":1632330709000},"page":"143-147","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Durable Improvement in Generic and Fibroid-Specific Quality of Life in Women Treated with Transcervical Fibroid Ablation with the Sonata System After Three Years"],"prefix":"10.1177","volume":"38","author":[{"given":"Kelly","family":"Roy","sequence":"first","affiliation":[{"name":"Arizona Gynecology Consultants, Phoenix, Arizona, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James K.","family":"Robinson","sequence":"additional","affiliation":[{"name":"MedStar Washington Hospital Center, Washington, District of Columbia, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2006.15.818"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001438"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2019.0550"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2017.05.021"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2018.09.772"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13669-017-0194-2"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.03.053"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003032"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1089\/gyn.2019.0012"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/gyn.2020.0021"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853890109002087"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-6-99"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-11-211"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-8-116"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-004-7713-0"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.300.6719.230"},{"key":"e_1_3_5_18_2","unstructured":"Phillips C. 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