{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T02:14:46Z","timestamp":1788488086810,"version":"build-2803163510"},"reference-count":14,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T00:00:00Z","timestamp":1414713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"published-print":{"date-parts":[[2014,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Goodman, Jessica, Kathryn Hassell, David Irwin, Ewa H. Witkowski, and Rachelle Nuss. The splenic syndrome in individuals with sickle cell trait.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol<\/jats:italic>\n                    15:468\u2013471, 2014.\u2014The medical records of 25 individuals with sickle cell trait and altitude-associated splenic infarct, reported to two Colorado physicians, were reviewed. Electrospray mass spectroscopy was performed on blood samples from a cohort of 10 of the individuals to rapidly confirm beta hemoglobin phenotype. Only males were identified with a 1.4:1 ratio of non-African Americans to African Americans, and 44% of African Americans and 85% of non-African Americans were unaware they had sickle cell trait. Left upper quadrant pain and an elevated bilirubin were nearly uniformly present. Either abdominal CT or ultrasound was confirmatory. Conservative treatment at a lower altitude generally resulted in a favorable outcome.\n                  <\/jats:p>","DOI":"10.1089\/ham.2014.1034","type":"journal-article","created":{"date-parts":[[2014,10,31]],"date-time":"2014-10-31T16:52:42Z","timestamp":1414774362000},"page":"468-471","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":34,"title":["The Splenic Syndrome in Individuals with Sickle Cell Trait"],"prefix":"10.1177","volume":"15","author":[{"given":"Jessica","family":"Goodman","sequence":"first","affiliation":[{"name":"St. Vincent's Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Hassell","sequence":"additional","affiliation":[{"name":"Colorado Sickle Cell Treatment and Research Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Irwin","sequence":"additional","affiliation":[{"name":"Cardiology at the University of Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa H.","family":"Witkowski","sequence":"additional","affiliation":[{"name":"Department of Cell and Tissue Biology at the University of California San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachelle","family":"Nuss","sequence":"additional","affiliation":[{"name":"Colorado Sickle Cell Treatment and Research Center"},{"name":"The Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,10,31]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-057604"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-2008-1078"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22271"},{"key":"e_1_3_3_5_1","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1001\/jama.1985.03350390093033","article-title":"Splenic syndrome at mountain altitudes in sickle cell trait. 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