{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:10:50Z","timestamp":1787008250656,"version":"build-2736575974"},"reference-count":8,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"published-print":{"date-parts":[[2015,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Murdoch, David R. Revisiting the cause of focal neurological deficits and profound dyspnea at high altitude\u2014the potential role of patent foramen ovale.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol<\/jats:italic>\n                    16:350\u2013351, 2015.\u2014A 49-year-old man developed weakness due to acute infarction of the left precentral gyrus. Subsequent investigation revealed a large patent foramen ovale (PFO), and it was concluded that the cerebral infarction was likely caused by a paradoxical embolus in association with the PFO. In hindsight, the PFO may explain several previous transient focal neurological deficits, some of which had occurred at high altitude and had been attributed to migraine. Furthermore, the large PFO may explain several episodes of profound shortness of breath that had occurred while exercising at high altitude during his lifetime, typically above 5000\u2009m. Arterial hypoxemia due to hypobaric hypoxia may be exacerbated in individuals with PFO and affect physical performance at high altitude.\n                  <\/jats:p>","DOI":"10.1089\/ham.2015.0064","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T11:32:51Z","timestamp":1437651171000},"page":"350-351","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Revisiting the Cause of Focal Neurological Deficits and Profound Dyspnea at High Altitude\u2014The Potential Role of Patent Foramen Ovale"],"prefix":"10.1177","volume":"16","author":[{"given":"David R.","family":"Murdoch","sequence":"first","affiliation":[{"name":"University of Otago","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,7,23]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.24.2954"},{"key":"e_1_3_3_3_1","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1378\/chest.14-1353","article-title":"Exaggerated pulmonary hypertension and right ventricular dysfunction in high-altitude dwellers with patent foramen ovale","volume":"147","author":"Brenner R","year":"2015","unstructured":"Brenner R, , Pratali L, , Rimoldi SF, , Murillo Jauregui CX, , Soria R, , Rexhaj E, , Salinas Salmon C, , Villena M, , Romero C, , Sartori C, , Allemann Y, , and Scherrer U. 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