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Inhaled budesonide does not affect hypoxic pulmonary vasoconstriction at 4559 meters of altitude.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol<\/jats:italic>\n                    19:52\u201359, 2018.\u2014Oral intake of the corticosteroid dexamethasone has been shown to lower pulmonary artery pressure (PAP) and to prevent high-altitude pulmonary edema. This study tested whether inhalation of the corticosteroid budesonide attenuates PAP and right ventricular (RV) function after rapid ascent to 4559\u2009m. In this prospective, randomized, double-blind, and placebo-controlled trial, 50 subjects were randomized into three groups to receive budesonide at 200 or 800\u2009\u03bcg twice\/day (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200916 and 17, respectively) or placebo (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200917). Inhalation was started 1 day before ascending from 1130 to 4559\u2009m within 20 hours. Systolic PAP (SPAP) and RV function were assessed by transthoracic echocardiography at low altitude (423\u2009m) and after 7, 20, 32, and 44 hours at 4559\u2009m. Ascent to high altitude increased SPAP about 1.7-fold (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), whereas RV function was preserved. There was no difference in SPAP and RV function between groups at low and high altitude (all\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    values &gt;0.10). Capillary partial pressure of oxygen (PO\n                    <jats:sub>2<\/jats:sub>\n                    ) and carbon dioxide as well as the alveolar to arterial PO\n                    <jats:sub>2<\/jats:sub>\n                    difference were decreased at high altitude but not affected by budesonide. Prophylactic inhalation of budesonide does not attenuate high-altitude-induced pulmonary vasoconstriction and RV function after rapid ascent to 4559\u2009m.\n                  <\/jats:p>","DOI":"10.1089\/ham.2017.0113","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T14:42:50Z","timestamp":1514990570000},"page":"52-59","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Inhaled Budesonide Does Not Affect Hypoxic Pulmonary Vasoconstriction at 4559 Meters of Altitude"],"prefix":"10.1177","volume":"19","author":[{"given":"Marc Moritz","family":"Berger","sequence":"first","affiliation":[{"name":"Paracelsus Medical University","place":["Austria"]},{"name":"University Hospital Heidelberg","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Macholz","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Fried","sequence":"additional","affiliation":[{"name":"University Hospital Heidelberg","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tabea","family":"Perz","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Dankl","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Niebauer","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"B\u00e4rtsch","sequence":"additional","affiliation":[{"name":"University Hospital Heidelberg","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heimo","family":"Mairb\u00e4url","sequence":"additional","affiliation":[{"name":"University Hospital Heidelberg","place":["Germany"]},{"name":"German Center for Lung Research (DZL)","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi","family":"Sareban","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1152\/ajpheart.2000.279.4.H2013","article-title":"Echocardiographic and invasive measurements of pulmonary artery pressure correlate closely at high altitude","volume":"279","author":"Allemann Y","year":"2000","unstructured":"Allemann Y, , Sartori C, , Lepori M, , Pierre S, , Melot C, , Naeije R, , Scherrer U, , and Maggiorini M. 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