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In this study, we present a case of a 58-year-old woman who was initially diagnosed with HAPE, although further evaluation revealed the presence of two underlying contributors to her significant hypoxemia at altitude. We discuss the medical workup for causes of greater than expected hypoxemia at altitude and the role some relevant medical comorbidities may play.<\/jats:p>","DOI":"10.1089\/ham.2018.0109","type":"journal-article","created":{"date-parts":[[2019,6,25]],"date-time":"2019-06-25T10:13:41Z","timestamp":1561457621000},"page":"181-186","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["The Complexity of Diagnosing High-Altitude Pulmonary Edema: A Case Report and Review of the Differential Diagnosis of Greater Than Expected Hypoxemia at Altitude"],"prefix":"10.1177","volume":"20","author":[{"given":"Elaine","family":"Reno","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, Colorado."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danika","family":"Evans","sequence":"additional","affiliation":[{"name":"Rocky Vista University College of Osteopathic Medicine, Parker, Colorado."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, Colorado."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,6,21]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.24.2954"},{"key":"e_1_3_3_3_1","first-page":"28","article-title":"Prevalence of coronary risk factors, clinical presentation, and complications in acute coronary syndrome patients living at high vs low altitudes in Yemen","volume":"8","author":"Al-Huthi MA","year":"2006","unstructured":"Al-Huthi MA, , Raja'a YA, , Al-Noami M, , and Abdul Rahman AR. 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