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These are rich sources of diverse bioactive metabolites having prophylactic and therapeutic uses against a wide array of neurodegenerative diseases. The objective of this study was to elucidate the prophylactic and neuroprotective efficacy of formulated phytococktail (PC) against simulated HH-induced neurodegeneration in male Sprague Dawley (SD) rats.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A PC containing\n                      <jats:italic toggle=\"yes\">H. rhamnoides<\/jats:italic>\n                      fruit pulp,\n                      <jats:italic toggle=\"yes\">P. armeniaca<\/jats:italic>\n                      fruit pulp, and\n                      <jats:italic toggle=\"yes\">R. imbricata<\/jats:italic>\n                      dry root extract (100:50:1) was formulated. The neuroprotective efficacy of PC was evaluated in male SD rats following exposure to 7 day HH at simulated altitude (25,000 ft, 282\u2009mm Hg). Rats were divided into four groups viz., normoxia group (NOR), normoxic group treated with PC (NORPC), 7 day hypoxic group treated with vehicle (7DH), and 7 day hypoxic group treated with PC (7DHPC). Memory impairment and neuromorphological alterations were measured. Targeted protein expression was analyzed by immunoblotting study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>PC supplementation significantly reduced the oxidative stress markers during exposure to HH. Spatial memory impairment by HH was significantly ameliorated by PC. HH-induced augmented pyknosis, decreased dendritic arborization, and increased Hoechst-positive neurons in hippocampal CA3 region were significantly ameliorated by PC. Immunoblotting study showed upregulation of BDNF and TrkB expression by PC. PC also prevented the hippocampal neurodegeneration by activating the PI3K\/AKT signaling pathway, which leads to GSK-3\u03b2 inactivation by its phosphorylation and alleviation of hippocampal Caspase3 expression leading to inhibition of apoptotic neuronal cell death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The present study advocates the potential role of PC as an effective neuroprotective supplement in preventing HH-induced neurodegeneration. Activation of the PI3K\/Akt pathway through BDNF\/TrkB interaction following PC supplementation after exposure to HH inhibits hippocampal neuronal apoptosis and memory impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ham.2019.0011","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T14:19:26Z","timestamp":1569334766000},"page":"279-292","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Trans-Himalayan Phytococktail Confers Protection Against Hypobaric Hypoxia-Induced Hippocampal Neurodegeneration and Memory Impairment in Male Sprague Dawley Rats"],"prefix":"10.1177","volume":"20","author":[{"given":"Priyanka","family":"Dhar","sequence":"first","affiliation":[{"name":"Defense Institute of High Altitude Research, Defense Research and Development Organization, Leh-Ladakh, India."},{"name":"Department of Biotechnology, Techno India University, Salt Lake City, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saroj Kumar","family":"Das","sequence":"additional","affiliation":[{"name":"Defense Institute of High Altitude Research, Defense Research and Development Organization, Leh-Ladakh, India."},{"name":"Center for Biotechnology, Siksha \u2018O\u2019 Anusandhan (Deemed to be University), Bhubaneswar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalpana","family":"Barhwal","sequence":"additional","affiliation":[{"name":"Defense Institute of High Altitude Research, Defense Research and Development Organization, Leh-Ladakh, India."},{"name":"All India Institute of Medical Sciences, Bhubaneswar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil Kumar","family":"Hota","sequence":"additional","affiliation":[{"name":"Defense Institute of High Altitude Research, Defense Research and Development Organization, Leh-Ladakh, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamla Prasad","family":"Mishra","sequence":"additional","affiliation":[{"name":"Defense Institute of Physiology and Allied Sciences, Defense Research and Development Organization, Timarpur, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashi Bala","family":"Singh","sequence":"additional","affiliation":[{"name":"Defense Institute of Physiology and Allied Sciences, Defense Research and Development Organization, Timarpur, India."},{"name":"National Institute of Pharmaceutical Education and Research, Balanagar, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,24]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2165\/00007256-199316020-00003","article-title":"Effects of altitude on mood, behaviour and cognitive functioning. 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