{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:45:52Z","timestamp":1777661152307,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Middle ear (ME) pressure regulation has been suggested as a physiological mechanism that maintains pressure equilibrium between the ME and the ambient environment. This mechanism would be based on a complex sensorineural reflex loop composed of mechanoreceptors, an integrative center, and efferent neural pathways. Our aim was to demonstrate that hypoxic conditions, which would inhibit mechanoreceptors in general, similarly participate in the inhibition of the opening of the Eustachian tube (ET), and thus, to suggest that such receptors are involved in the overall regulation of ME pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Among 14 healthy volunteers, tubomanometry was performed in normoxia followed by hypoxia, and 3 parameters were evaluated for each ear under each condition, allowing the evaluation of the reactivity of the system: ET opening latency index (R), the Index of Velum Contraction (IVC), and the latency of pressure instauration (C2\u2013C1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Hypoxia induced a significant increase in the opening latency index of ET opening, without deleterious effects on the quality (IVC) and latency (C2\u2013C1) of soft palate contraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our study supports the theory of a sensorineural reflex loop and provides evidence for the existence of mechanoreceptors, whose function is modified by changes in oxygen partial pressure, able to collect information on pressure variations between the ME and the external environment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ham.2019.0043","type":"journal-article","created":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T10:57:41Z","timestamp":1580122661000},"page":"99-104","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The Effects of Hypoxia on Middle Ear Pressure Regulation"],"prefix":"10.1177","volume":"21","author":[{"given":"Abdullah","family":"Alshukry","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Conception Hospital, APHM, Marseille, France."},{"name":"Ministry of Health, Zain Center of Otorhinolaryngology and Head and Neck Surgery, Kuwait City, Kuwait."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Lagier","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Conception Hospital, APHM, Marseille, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Della Vedova","sequence":"additional","affiliation":[{"name":"Private Practice, Manosque, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florent","family":"Salburgo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Conception Hospital, APHM, Marseille, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Lavieille","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Conception Hospital, APHM, Marseille, France."},{"name":"Aix Marseille Universit\u00e9, IFSSTAR, LBA, UMR-T 24, Marseille, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Montava","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, Conception Hospital, APHM, Marseille, France."},{"name":"Aix Marseille Universit\u00e9, IFSSTAR, LBA, UMR-T 24, Marseille, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1113\/jphysiol.2004.062513","article-title":"Effects of simulated obstructive sleep apnoea on the human carotid baroreceptor\u2013vascular resistance reflex","volume":"557","author":"Cooper VL","year":"2004","unstructured":"Cooper VL, , Bowker CM, , Pearson SB, , Elliott MW, , and Hainsworth R. 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