{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:10:50Z","timestamp":1787008250596,"version":"build-2736575974"},"reference-count":11,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:p>A 36-year-old woman with no medical history participated in a trekking in Ladakh up to 5300\u2009m of altitude. She was well acclimatized and presented no previous sign of acute mountain sickness, high altitude pulmonary edema or high altitude cerebral edema. After an intense effort to catch up with her group, she became breathless and complained of visual disturbances, fatigue, dizziness, and confusion. During her descent to a lower altitude (4800\u2009m), with the help of companions, she lost consciousness several times. After a 14-hour sleep, she recovered and all symptoms disappeared so that she was able to walk along with the group for 20\u2009km. On returning home, she went through a battery of examinations that were all normal: cerebral magnetic resonance imaging, Doppler of supra-aortic arteries, 24 hours Holter, and cardiac transthoracic and transesophageal echography. A hypoxia exercise test revealed a hyper-response to hypoxia with severe hypocapnia. The etiology of this neurological episode is discussed (transient embolic ischemic attack, migraine, cerebral edema, and global amnesia). The patchy distribution of neurological symptoms is not in favor of a thrombotic event. The most probable diagnosis proposed is a transient cerebral ischemia due to local cerebral vasoconstriction related to hyperventilation-induced hypocapnia in a context of acute severe exercise. Special attention should be given to subjects who show a hyper-responsiveness to hypoxia before a sojourn at high altitude: they should avoid unnecessary hyperventilation due to any kind of stress, emotion, or exhaustive exercise.<\/jats:p>","DOI":"10.1089\/ham.2019.0100","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T12:27:37Z","timestamp":1579782457000},"page":"105-108","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Transient Cerebral Ischemia at High Altitude and Hyper-Responsiveness to Hypoxia"],"prefix":"10.1177","volume":"21","author":[{"given":"Jean-Paul","family":"Richalet","sequence":"first","affiliation":[{"name":"INSERM U1272 Hypoxie et Poumon, Universit\u00e9 Paris 13, Bobigny, France."},{"name":"Association pour la Recherche en Physiologie de l'Environnement, Bobigny, France."},{"name":"Institut National du Sport, de l'Expertise et de la Performance, P\u00f4le m\u00e9dical, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Larmignat","sequence":"additional","affiliation":[{"name":"Association pour la Recherche en Physiologie de l'Environnement, Bobigny, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Poignard","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris, H\u00f4pital Jean-Verdier, Service de Physiologie et Explorations Fonctionnelles, Bondy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/1527029041352126"},{"key":"e_1_3_4_3_1","first-page":"296","article-title":"Afasia motora transitoria a gran altitud","volume":"193","author":"Botella De Maglia J","year":"1993","unstructured":"Botella De Maglia J, , Garrido Marin E, , and Catala Barcelo J. (1993). Afasia motora transitoria a gran altitud. Rev Clin Esp, 193:296\u2013298.","journal-title":"Rev Clin Esp"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415610876"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2008.0002"},{"key":"e_1_3_4_6_1","first-page":"1224","article-title":"Case report: Clinical medicine: Transient neurological disorders during a simulated ascent of Mount Everest","volume":"73","author":"Cauchy E","year":"2002","unstructured":"Cauchy E, , Larmignat P, , Boussuges A, , Le Roux G, , Charniot JC, , Dumas JL, , and Richalet JP. (2002). Case report: Clinical medicine: Transient neurological disorders during a simulated ascent of Mount Everest. 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