{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:46:57Z","timestamp":1777661217030,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:p>\n                    Uday, Yanamandra, Revanth Boddu, Suman Pramanik, Kundan Mishra, Rajan Kapoor, Ankur Ahuja, Tathagata Chatterjee, and Satyaranjan Das. Prevalence and clinical characteristics of post-thrombotic syndrome in high-altitude\u2013induced deep vein thrombosis: experience of a single tertiary care center from real-world settings.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol<\/jats:italic>\n                    . 21:319\u2013326, 2020.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Exposure to high altitude (HA) is a recognized predisposing factor for venous thrombosis. Post-thrombotic syndrome (PTS) is a significant late complication, occurring in \u223c30%\u201350% of patients of deep vein thrombosis (DVT). There are not many studies about the characteristics of PTS in patients with HA-DVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim was to study the epidemiology and clinical characteristics of PTS using a noninvasive Villalta score and identify the risk factors for its development in patients with HA-DVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>\n                      This is a retrospective single-center observational study (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200947). The diagnosis of HA-DVT was confirmed using color Doppler ultrasonography at HA. The patients were managed with low molecular weight heparin, followed by vitamin K antagonist therapy till normalization of D-dimer and imaging. The therapeutic target range of &gt;80% was ensured. Villalta scale was used for PTS assessment. JMP 15.0 was used for statistical analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All study participants were male with a median age of 34 years, of which 46.81% developed PTS with mean Villalta of 5.29\u2009\u00b1\u20094.25. The most common symptom was pain (87.23%;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200941), whereas the most common sign was hyperpigmentation (42.5%;\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200920). On multivariate analysis, the time from onset of DVT and the extent of DVT were related to the development of PTS (degree of freedom [dF]\u2009=\u20095, \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200917.34,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.0039) with a likelihood ratio of 4.95 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.026) and 4.96 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.026), respectively. The extent of DVT was associated with the severity of PTS (dF\u2009=\u20095, \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200912.6,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.0273) with a likelihood ratio of 5.24 (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.022).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>PTS develops in approximately half of the patients with HA-DVT. The extent of DVT is a significant risk factor for both development of PTS and its severity, whereas time to assessment of PTS from the onset of DVT was associated only with the occurrence of PTS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ham.2020.0053","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T17:38:09Z","timestamp":1595612289000},"page":"319-326","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence and Clinical Characteristics of Post-Thrombotic Syndrome in High-Altitude\u2013Induced Deep Vein Thrombosis: Experience of a Single Tertiary Care Center from Real-World Settings"],"prefix":"10.1177","volume":"21","author":[{"given":"Uday","family":"Yanamandra","sequence":"first","affiliation":[{"name":"Clinical Hematology, and Department of Hematology &amp; Stem Cell Transplant, Army Hospital (Research &amp; Referral), Delhi, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Revanth","family":"Boddu","sequence":"additional","affiliation":[{"name":"Clinical Hematology, and Department of Hematology &amp; Stem Cell Transplant, Army Hospital (Research &amp; Referral), Delhi, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suman","family":"Pramanik","sequence":"additional","affiliation":[{"name":"Clinical Hematology, and Department of Hematology &amp; Stem Cell Transplant, Army Hospital (Research &amp; Referral), Delhi, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kundan","family":"Mishra","sequence":"additional","affiliation":[{"name":"Clinical Hematology, and Department of Hematology &amp; Stem Cell Transplant, Army Hospital (Research &amp; Referral), Delhi, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajan","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Clinical Hematology, and Department of Hematology &amp; Stem Cell Transplant, Army Hospital (Research &amp; Referral), Delhi, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankur","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Hematopathology, Department of Hematology &amp; Stem Cell Transplant, Army Hospital (Research &amp; Referral), Delhi, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tathagata","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Hematopathology, Department of Hematology &amp; Stem Cell Transplant, Army Hospital (Research &amp; Referral), Delhi, India."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satyaranjan","family":"Das","sequence":"additional","affiliation":[{"name":"Clinical Hematology, and Department of Hematology &amp; Stem Cell Transplant, Army Hospital (Research &amp; Referral), Delhi, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613447"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-009-0309-3"},{"key":"e_1_3_4_4_1","first-page":"238","article-title":"Prevention of recurrent venous thrombosis and post-thrombotic syndrome","volume":"66","author":"Belcaro G","year":"2018","unstructured":"Belcaro G, , Dugall M, , Hu S, , Feragalli B, , Cotellese R, , Ledda A, , Corsi M, , Ricci A, , Ippolito E, , and Errichi BM. 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