{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:48:07Z","timestamp":1777661287522,"version":"3.51.4"},"reference-count":7,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine & Biology"],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"\n Ribeiro Baptista, Bruno, Morgane Faure, Gimbada Benny Mwenge, Capucine Morelot-Panzini, Christian Straus, Thomas Similowski, and J\u00e9sus Gonzalez-Bermejo. Feasibility of a hypoxic challenge test under noninvasive ventilation versus oxygen in neuromuscular patients with chronic respiratory insufficiency.\n High Alt Med Biol.<\/jats:italic>\n 22:346\u2013350, 2021.\n <\/jats:p>\n \n Background:<\/jats:title>\n \n The British Thoracic Society recommendations suggest that all patients with an oxygen saturation (SpO\n 2<\/jats:sub>\n ) <85% during a hypoxic challenge test (HCT) should receive supplemental oxygen during air travel. However, neuromuscular patients already using ventilatory support are a specific population and noninvasive ventilation (NIV) during a flight could be an alternative to oxygen for hypoxemia correction, through the augmentation of ventilation.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n We conducted a comparative, observational study of neuromuscular patients with chronic respiratory failure, requiring nocturnal mechanical ventilation, who were planning to take a flight. HCT was performed with a ventilated canopy placed over the patient's head or the patient's home ventilator. The positive threshold value chosen for the HCT was <90% SpO\n 2<\/jats:sub>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n HCTs were performed on 13 adults with neuromuscular diseases using their home ventilator. Among them, 11 had a positive HCT. For all patients with a positive test, hypoxemia was corrected (SpO\n 2<\/jats:sub>\n to >90%) by oxygen therapy (+9 [6\u201312]%,\n p<\/jats:italic>\n \u2009=\u20090.0029). Patient's home ventilator also significantly increased the SpO\n 2<\/jats:sub>\n by 8 [7\u201312]% (\n p<\/jats:italic>\n \u2009=\u20090.016). Correction of SpO\n 2<\/jats:sub>\n during the HCT was not different between oxygen and NIV. NIV was associated with a significant decrease in pressure, end tidal, carbon dioxide (PetCO\n 2<\/jats:sub>\n ) (\u221210 [\u221216 to \u22127.5] mmHg,\n p<\/jats:italic>\n \u2009=\u20090.04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n The performance of an adapted HCT in home-ventilated patients with a neuromuscular pathology may be useful in a personalized treatment plan for air travel. NIV can be a new alternative to oxygen therapy for neuromuscular patients planning to take a flight.<\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/ham.2020.0199","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T23:36:05Z","timestamp":1624923365000},"page":"346-350","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Feasibility of a Hypoxic Challenge Test Under Noninvasive Ventilation Versus Oxygen in Neuromuscular Patients with Chronic Respiratory Insufficiency"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0870-3352","authenticated-orcid":false,"given":"Bruno","family":"Ribeiro Baptista","sequence":"first","affiliation":[{"name":"AP-HP, Groupe Hospitalier Universitaire Piti\u00e9-Salp\u00eatri\u00e8re-Charles Foix, Service de Pneumologie, M\u00e9decine Intensive et R\u00e9animation (D\u00e9partement R3S), Paris, France."},{"name":"D\u00e9partement de Pneumologie, CHRU de Nancy, Vand\u0153uvre-l\u00e8s-Nancy, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgane","family":"Faure","sequence":"additional","affiliation":[{"name":"AP-HP, Groupe Hospitalier Universitaire Piti\u00e9-Salp\u00eatri\u00e8re-Charles Foix, Service de Pneumologie, M\u00e9decine Intensive et R\u00e9animation (D\u00e9partement R3S), Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gimbada Benny","family":"Mwenge","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pneumologie et Centre de M\u00e9decine du Sommeil, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Capucine","family":"Morelot-Panzini","sequence":"additional","affiliation":[{"name":"AP-HP, Groupe Hospitalier Universitaire Piti\u00e9-Salp\u00eatri\u00e8re-Charles Foix, Service de Pneumologie, M\u00e9decine Intensive et R\u00e9animation (D\u00e9partement R3S), Paris, France."},{"name":"Sorbonne Universit\u00e9, INSERM, UMRS1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Straus","sequence":"additional","affiliation":[{"name":"AP-HP, Groupe Hospitalier Universitaire Piti\u00e9-Salp\u00eatri\u00e8re-Charles Foix, Service de Pneumologie, M\u00e9decine Intensive et R\u00e9animation (D\u00e9partement R3S), Paris, France."},{"name":"Sorbonne Universit\u00e9, INSERM, UMRS1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Similowski","sequence":"additional","affiliation":[{"name":"AP-HP, Groupe Hospitalier Universitaire Piti\u00e9-Salp\u00eatri\u00e8re-Charles Foix, Service de Pneumologie, M\u00e9decine Intensive et R\u00e9animation (D\u00e9partement R3S), Paris, France."},{"name":"Sorbonne Universit\u00e9, INSERM, UMRS1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9sus","family":"Gonzalez-Bermejo","sequence":"additional","affiliation":[{"name":"AP-HP, Groupe Hospitalier Universitaire Piti\u00e9-Salp\u00eatri\u00e8re-Charles Foix, Service de Pneumologie, M\u00e9decine Intensive et R\u00e9animation (D\u00e9partement R3S), Paris, France."},{"name":"Sorbonne Universit\u00e9, INSERM, UMRS1158 Neurophysiologie Respiratoire Exp\u00e9rimentale et Clinique, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"issue":"1","key":"e_1_3_5_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/thoraxjnl-2011-200295","article-title":"Managing passengers with stable respiratory disease planning air travel: British Thoracic Society recommendations","volume":"66","author":"Ahmedzai S","year":"2011","unstructured":"Ahmedzai S, , Balfour-Lynn IM, , Bewick T, , Buchdahl R, , Coker RK, , Cummin AR, , Gradwell DP, , Howard L, , Innes JA, , Johnson AOC, , Lim E, , Lim WS, , McKinlay KP, , Partridge MR, , Popplestone M, , Pozniak A, , Robson A, , Shovlin CL, , Shrikrishna D, , Simonds A, , Tait P, , Thomas M, , British Thoracic Society Standards of Care Committee. (2011). Managing passengers with stable respiratory disease planning air travel: British Thoracic Society recommendations. Thorax, 66(Suppl 1):i1\u2013i30.","journal-title":"Thorax"},{"key":"e_1_3_5_3_1","doi-asserted-by":"crossref","first-page":"180030","DOI":"10.1183\/16000617.0030-2018","article-title":"Should I stay or should I go? COPD and air travel","volume":"27","author":"Ergan B","year":"2018","unstructured":"Ergan B, , Akgun M, , Pacilli AMG, , Nava S. (2018). Should I stay or should I go? COPD and air travel. Eur Respir Rev, 27:180030.","journal-title":"Eur Respir Rev"},{"key":"e_1_3_5_4_1","unstructured":"ICAO's Annual Report of the Council. (2018). www.icao.int\/annual-report-2018"},{"key":"e_1_3_5_5_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1378\/chest.112.1.207","article-title":"Noninvasive positive pressure ventilation and not oxygen may prevent overt ventilatory failure in patients with chest wall diseases","volume":"112","author":"Masa JF","year":"1997","unstructured":"Masa JF, , Celli BR, , Riesco JA, , S\u00e1nchez de Cos J, , Disdier C, , Sojo A. (1997). Noninvasive positive pressure ventilation and not oxygen may prevent overt ventilatory failure in patients with chest wall diseases. Chest, 112:207\u2013213.","journal-title":"Chest"},{"key":"e_1_3_5_6_1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1136\/thx.2008.099143","article-title":"Hypoxic challenge flight assessments in patients with severe chest wall deformity or neuromuscular disease at risk for nocturnal hypoventilation","volume":"64","author":"Mestry N","year":"2009","unstructured":"Mestry N, , Thirumaran M, , Tuggey JM, , Macdonald W, , Elliott MW. (2009). Hypoxic challenge flight assessments in patients with severe chest wall deformity or neuromuscular disease at risk for nocturnal hypoventilation. Thorax, 64:532\u2013534.","journal-title":"Thorax"},{"key":"e_1_3_5_7_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1046\/j.1365-2044.1999.00839.x","article-title":"Cor pulmonale presenting in a patient with congenital kyphoscoliosis following intercontinental air travel","volume":"54","author":"Noble JS","year":"1999","unstructured":"Noble JS, , Davidson JA. (1999). Cor pulmonale presenting in a patient with congenital kyphoscoliosis following intercontinental air travel. Anaesthesia, 54:361\u2013363.","journal-title":"Anaesthesia"},{"key":"e_1_3_5_8_1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1136\/thx.2009.121277","article-title":"Oxygen or ventilation during flight for patients with neuromuscular disease?","volume":"65","author":"Winck JC","year":"2010","unstructured":"Winck JC, , Gon\u00e7alves MR, , Silva N. (2010). Oxygen or ventilation during flight for patients with neuromuscular disease?. 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