{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T18:48:09Z","timestamp":1777661289232,"version":"3.51.4"},"reference-count":61,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine & Biology"],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"\n Slivka, Dustin, Charles Dumke, Walter Hailes, and Brent Ruby. Impact of hypoxic exercise recovery on skeletal muscle glycogen and gene expression.\n High Alt Med Biol<\/jats:italic>\n . 22:300\u2013307, 2021.\n <\/jats:p>\n \n Background:<\/jats:title>\n The impact of altitude during recovery from exercise is largely unknown. The purpose of this study was to determine the acute gene response and muscle glycogen re-synthesis after exercise when exposed to simulated high altitude during recovery.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Twelve male participants (age, 25\u2009\u00b1\u20092 years; height, 178\u2009\u00b1\u20097\u2009cm; weight, 78.8\u2009\u00b1\u20097.8\u2009kg; VO\n 2<\/jats:sub>\n peak, 4.25\u2009\u00b1\u20090.59 l\/min; Wpeak 307\u2009\u00b1\u200944 W; and body fat, 13.1%\u2009\u00b1\u20091.2%) completed two trials (random order), which consisted of cycling for 90 minutes in laboratory conditions and then recovering for 6 hours in laboratory conditions (975\u2009m; normoxia) or at a high simulated altitude (5,000\u2009m; hypoxia).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Skeletal muscle biopsies from the vastus lateralis were obtained before exercise, after exercise, and 6 hours after exercise for the measurement of metabolic gene expression and muscle glycogen. Muscle glycogen decreased with exercise (61%\u2009\u00b1\u200913%,\n p<\/jats:italic>\n \u2009<\u20090.05) and increased with recovery (78%\u2009\u00b1\u200935%,\n p<\/jats:italic>\n \u2009<\u20090.05) with no difference between trials (\n p<\/jats:italic>\n \u2009>\u20090.05). Hypoxia-inducible factor (\n HIF<\/jats:italic>\n )-1\u03b1,\n HIF-2\u03b1<\/jats:italic>\n , optic atrophy gene 1 (\n OPA-1<\/jats:italic>\n ), mitofusin 2 (\n MFN-2<\/jats:italic>\n ), and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (\n PGC-1\u03b1<\/jats:italic>\n ) gene expression were suppressed after altitude exposure (\n p<\/jats:italic>\n \u2009<\u20090.05), while mitochondrial fission 1 protein (\n FIS-1<\/jats:italic>\n ), phosphofructokinase (\n PFK<\/jats:italic>\n ), Cytochrome c oxidase (\n COX<\/jats:italic>\n ), and hexokinase (\n HK<\/jats:italic>\n ) were unaffected by altitude exposure (\n p<\/jats:italic>\n \u2009>\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n High-altitude exposure during recovery from exercise inhibits gene expression associated with mitochondrial development without affecting muscle glycogen re-synthesis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1089\/ham.2021.0028","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T11:39:41Z","timestamp":1624016381000},"page":"300-307","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Hypoxic Exercise Recovery on Skeletal Muscle Glycogen and Gene Expression"],"prefix":"10.1177","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7337-3770","authenticated-orcid":false,"given":"Dustin","family":"Slivka","sequence":"first","affiliation":[{"name":"School of Health and Kinesiology, University of Nebraska at Omaha, Omaha, Nebraska, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Dumke","sequence":"additional","affiliation":[{"name":"School of Integrative Physiology and Athletic Training, University of Montana, Missoula, Montana, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Hailes","sequence":"additional","affiliation":[{"name":"School of Integrative Physiology and Athletic Training, University of Montana, Missoula, Montana, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent","family":"Ruby","sequence":"additional","affiliation":[{"name":"School of Integrative Physiology and Athletic Training, University of Montana, Missoula, Montana, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"e_1_3_4_2_1","first-page":"7","article-title":"Higher muscle tissue oxygenation when exposed to hypobaric hypoxia than normobaric hypoxia","author":"Angeli C","year":"2019","unstructured":"Angeli C, , Shute R, , and Slivka D. 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