{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:21:35Z","timestamp":1777897295974,"version":"3.51.4"},"reference-count":107,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p>\n                    Committeri Giorgia, Danilo Bondi, Carlo Sestieri, Ginevra Di Matteo, Claudia Piervincenzi, Christian Doria, Roberto Ruffini, Antonello Baldassarre, Tiziana Pietrangelo, Rosamaria Sepe, Riccardo Navarra, Piero Chiacchiaretta, Antonio Ferretti, and Vittore Verratti. Neuropsychological and neuroimaging correlates of high-altitude hypoxia trekking during the \u201cGokyo Khumbu\/Ama Dablam\u201d expedition.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol<\/jats:italic>\n                    . 23:57\u201368, 2022.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Altitude hypoxia exposure may produce cognitive detrimental adaptations and damage to the brain. We aimed at investigating the effects of trekking and hypoxia on neuropsychological and neuroimaging measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We recruited two balanced groups of healthy adults, trekkers (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200912, 6 F and 6\u2009M, trekking in altitude hypoxia) and controls (gender- and age-matched), who were tested before (baseline), during (5,000\u2009m, after 9 days of trekking), and after the expedition for state anxiety, depression, verbal fluency, verbal short-term memory, and working memory. Personality and trait anxiety were also assessed at a baseline level. Neuroimaging measures of cerebral perfusion (arterial spin labeling), white-matter microstructural integrity (diffusion tensor imaging), and resting-state functional connectivity (functional magnetic resonance imaging) were assessed before and after the expedition in the group of trekkers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At baseline, the trekkers showed lower trait anxiety (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.003) and conscientiousness (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.03) than the control group. State anxiety was lower in the trekkers throughout the study (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and state anxiety and depression decreased at the end of the study in both groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.043 and\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.007, respectively). Verbal fluency increased at the end of the study in both groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas verbal short-term memory and working memory performance did not change. No significant differences between before and after the expedition were found for neuroimaging measures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We argue that the observed differences in the neuropsychological measures mainly reflect aspecific familiarity and learning effects due to the repeated execution of the same questionnaires and task. The present results thus suggest that detrimental effects on neuropsychological and neuroimaging measures do not necessarily occur as a consequence of short-term exposure to altitude hypoxia up to 5,000\u2009m, especially in the absence of altitude sickness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ham.2021.0029","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T16:57:47Z","timestamp":1643734667000},"page":"57-68","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Neuropsychological and Neuroimaging Correlates of High-Altitude Hypoxia Trekking During the \u201cGokyo Khumbu\/Ama Dablam\u201d Expedition"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2136-1246","authenticated-orcid":false,"given":"Giorgia","family":"Committeri","sequence":"first","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University \u201cG. d'Annunzio\u201d of Chieti-Pescara, Chieti, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1911-3606","authenticated-orcid":false,"given":"Danilo","family":"Bondi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University \u201cG. d'Annunzio\u201d of Chieti-Pescara, Chieti, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Sestieri","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University \u201cG. d'Annunzio\u201d of Chieti-Pescara, Chieti, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginevra","family":"Di Matteo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University \u201cG. d'Annunzio\u201d of Chieti-Pescara, Chieti, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Piervincenzi","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Doria","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences for Health, Universit\u00e0 Degli Studi di Milano, Milan, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Ruffini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University \u201cG. d'Annunzio\u201d of Chieti-Pescara, Chieti, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonello","family":"Baldassarre","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University \u201cG. d'Annunzio\u201d of Chieti-Pescara, Chieti, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiziana","family":"Pietrangelo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University \u201cG. d'Annunzio\u201d of Chieti-Pescara, Chieti, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosamaria","family":"Sepe","sequence":"additional","affiliation":[{"name":"Psykiatri Nordv\u00e4st, SLSO, Stockolm, Sweden."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Navarra","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University \u201cG. d'Annunzio\u201d of Chieti-Pescara, Chieti, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Chiacchiaretta","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University \u201cG. d'Annunzio\u201d of Chieti-Pescara, Chieti, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Ferretti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, University \u201cG. d'Annunzio\u201d of Chieti-Pescara, Chieti, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittore","family":"Verratti","sequence":"additional","affiliation":[{"name":"Department of Psychological, Health and Territorial Sciences, University \u201cG. d'Annunzio\u201d of Chieti-Pescara, Chieti, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"e_1_3_6_2_1","article-title":"Non-linear optimisation","author":"Andersson JLR","year":"2007","unstructured":"Andersson JLR, , Jenkinson M, , and Smith SM. 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