{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:18:22Z","timestamp":1790281102360,"version":"4.1.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p>\n                    Talks, Benjamin James, Catherine Campbell, Stephanie J. Larcombe, Lucy Marlow, Sarah L. Finnegan, Christopher T. Lewis, Samuel J.E. Lucas, Olivia K. Harrison, and Kyle T.S. Pattinson. Baseline psychological traits contribute to Lake Louise Acute Mountain Sickness score at high altitude.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol.<\/jats:italic>\n                    23:69\u201377, 2022.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Interoception refers to an individual's ability to sense their internal bodily sensations. Acute mountain sickness (AMS) is a common feature of ascent to high altitude that is only partially explained by measures of peripheral physiology. We hypothesized that interoceptive ability may explain the disconnect between measures of physiology and symptom experience in AMS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Two groups of 18 participants were recruited to complete a respiratory interoceptive task three times at 2-week intervals. The control group remained in Birmingham (140\u2009m altitude) for all three tests. The altitude group completed test 1 in Birmingham, test 2 the day after arrival at 2,624\u2009m, and test 3 at 2,728\u2009m after an 11-day trek at high altitude (up to 4,800\u2009m).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>By measuring changes to metacognitive performance, we showed that acute ascent to altitude neither presented an interoceptive challenge, nor acted as interoceptive training. However, AMS symptom burden throughout the trek was found to relate to sea level measures of anxiety, agoraphobia, and neuroticism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>This suggests that the Lake Louise AMS score is not solely a reflection of physiological changes on ascent to high altitude, despite often being used as such by researchers and commercial trekking companies alike.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ham.2021.0073","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T13:35:56Z","timestamp":1648647356000},"page":"69-77","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Baseline Psychological Traits Contribute to Lake Louise Acute Mountain Sickness Score at High Altitude"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4896-2324","authenticated-orcid":false,"given":"Benjamin James","family":"Talks","sequence":"first","affiliation":[{"name":"Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom."},{"name":"Birmingham Medical Research Expeditionary Society, Birmingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Campbell","sequence":"additional","affiliation":[{"name":"Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J.","family":"Larcombe","sequence":"additional","affiliation":[{"name":"Birmingham Medical Research Expeditionary Society, Birmingham, United Kingdom."},{"name":"Medical School, University of Birmingham, Birmingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Marlow","sequence":"additional","affiliation":[{"name":"Warwick Medical School, Warwick University, Coventry, United Kingdom."},{"name":"Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Finnegan","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9758-959X","authenticated-orcid":false,"given":"Christopher T.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Birmingham Medical Research Expeditionary Society, Birmingham, United Kingdom."},{"name":"Department of Anesthesia, Ysbyty Gwynedd, Bangor, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J.E.","family":"Lucas","sequence":"additional","affiliation":[{"name":"Birmingham Medical Research Expeditionary Society, Birmingham, United Kingdom."},{"name":"School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia K.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom."},{"name":"Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland."},{"name":"School of Pharmacy, University of Otago, Dunedin, New Zealand."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle T.S.","family":"Pattinson","sequence":"additional","affiliation":[{"name":"Birmingham Medical Research Expeditionary Society, Birmingham, United Kingdom."},{"name":"Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,28]]},"reference":[{"key":"e_1_3_7_2_1","first-page":"1900275","article-title":"Diminished opioid efficacy in the treatment of breathlessness is related to negative affect and anticipatory activiry in the anterior cingulate and medial prefrontal cortex","volume":"54","author":"Abdallah S","year":"2019","unstructured":"Abdallah S, , Faull O, , Wanigasekera V, , Finnegan S, , Jensen D, , and Pattinson K. 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