{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:10:40Z","timestamp":1787008240726,"version":"build-2736575974"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p>\n                    Vizcarra-Vizcarra, Cristhian A., Eduardo Ch\u00e1vez-Vel\u00e1zquez, Carmen Asato-Higa, and Abd\u00edas Hurtado-Ar\u00e9stegui. Treatment of focal and segmental glomerulosclerosis secondary to high altitude polycythemia with acetazolamide.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol<\/jats:italic>\n                    . 23:286\u2013290, 2022.\u2014Focal segmental glomerulosclerosis (FSGS) is a morphological pattern, caused by glomerular injury and is the leading cause of nephrotic syndrome in adults. We present the case of a 59-year-old female patient, resident of a high-altitude city (3,824\u2009m), who had polycythemia and nephrotic syndrome. A renal biopsy was performed, and the findings were compatible with FSGS. The patient received phlebotomy 500\u2009ml three times, which reduced, partially, the hemoglobin concentration. However, she had refractory proteinuria, despite the use of enalapril and spironolactone. We observed that proteinuria worsened with the increase in hemoglobin levels. So, she was treated with acetazolamide 250\u2009mg bid for 4 months, which reduced proteinuria and hemoglobin. During the coronavirus disease 2019 (COVID-19) pandemic, the patient did not take acetazolamide and again, she had an increase in hemoglobin and proteinuria levels. We conclude that acetazolamide may be an effective treatment in FSGS due to high altitude polycythemia.\n                  <\/jats:p>","DOI":"10.1089\/ham.2021.0158","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T12:14:13Z","timestamp":1649420053000},"page":"286-290","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Treatment of Focal and Segmental Glomerulosclerosis Secondary to High Altitude Polycythemia with Acetazolamide"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1068-7793","authenticated-orcid":false,"given":"Cristhian A.","family":"Vizcarra-Vizcarra","sequence":"first","affiliation":[{"name":"Nephrology Division, Honorio Delgado Regional Hospital, Arequipa, Peru."},{"name":"Faculty of Medicine, San Agustin National University, Arequipa, Peru."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Ch\u00e1vez-Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Nephrology Division, Honorio Delgado Regional Hospital, Arequipa, Peru."},{"name":"Faculty of Medicine, San Agustin National University, Arequipa, Peru."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Asato-Higa","sequence":"additional","affiliation":[{"name":"Pathology Division, Patologas AS SAC, Lima, Peru."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abd\u00edas","family":"Hurtado-Ar\u00e9stegui","sequence":"additional","affiliation":[{"name":"Nephrology Division, Arzobispo Loayza National Hospital, Lima, Peru."},{"name":"Faculty of Medicine, Cayetano Heredia Peruvian University, Lima, Peru."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"crossref","first-page":"220","DOI":"10.5500\/wjt.v11.i6.220","article-title":"Post-transplant erythrocytosis after kidney transplantation: A review","volume":"11","author":"Alzoubi B","year":"2021","unstructured":"Alzoubi B, , Kharel A, , Machhi R, , Aziz F, , Swanson KJ, , and Parajuli S. 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