{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:46:00Z","timestamp":1792226760429,"version":"4.4.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p>\n                    Zhang, Guangbo, Yanzhao Zhou, Zhengtao Cao, Xiang Cheng, Xiangpei Yue, Tong Zhao, Ming Zhao, Yongqi Zhao, Ming Fan, and Lingling Zhu. Preliminary intermittent hypoxia training alleviates the damage of sustained normobaric hypoxia on human hematological indexes and cerebral white matter.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol<\/jats:italic>\n                    . 23:273\u2013283, 2022.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We aimed to examine the effects of preliminary intermittent hypoxia training (IHT) on human hematological indexes and cerebral white matter (WM) after exposure to a simulated altitude of 4,300\u2009m.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We recruited 20 young healthy volunteers. Participants were then randomized to either the IHT group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200910) or the control group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200910). We measured the physiological function of the control group at sea level and after exposure to a simulated altitude of 4,300\u2009m, respectively. The IHT group performed the above tests at three time points: before and after hypoxia training, and after exposure to a simulated altitude of 4,300\u2009m, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We found that mean SpO\n                      <jats:sub>2<\/jats:sub>\n                      during day 10 of hypoxia training showed a significant increase compared with mean SpO\n                      <jats:sub>2<\/jats:sub>\n                      on day 1 (88.3%\u2009\u00b1\u20091.5% vs. 90.0%\u2009\u00b1\u20091.6%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05), and erythrocyte P\n                      <jats:sub>50<\/jats:sub>\n                      of post-training was significantly increased compared with pretraining (37.8\u2009\u00b1\u20092.9\u2009mmHg vs. 45.9\u2009\u00b1\u20096.4\u2009mmHg,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Mean SpO\n                      <jats:sub>2<\/jats:sub>\n                      measures after acute exposure to high altitude exhibited a significant difference, with the IHT group showing significantly greater SpO\n                      <jats:sub>2<\/jats:sub>\n                      than the control group (73.8%\u2009\u00b1\u20093.7% vs. 77.4%\u2009\u00b1\u20093.2%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05), and the Lake Louise Score was also lower than the control group (2.55\u2009\u00b1\u20092.1 vs. 6.67\u2009\u00b1\u20092.5,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). After daily IHT, brain-derived neurotrophic factor plasma levels of participants in the IHT group did not change but significantly increased in response to high-altitude hypoxia (103.5%\u2009\u00b1\u200970.4% vs. 29.7%\u2009\u00b1\u200973.2%,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Interleukin-10 (IL-10) plasma level did not change before and after IHT in the IHT group, whereas the IL-10 plasma level of the control group after high-altitude exposure was significantly higher. Furthermore, we found that fractional anisotropy values in the left corticospinal tract and splenium of the corpus callosum in the IHT group were significantly higher than those in the control group after high-altitude hypoxia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These results demonstrate that IHT alleviates the damage of sustained normobaric hypoxia on human hematological indexes and cerebral WM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ham.2021.0166","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T15:03:24Z","timestamp":1651244604000},"page":"273-283","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Preliminary Intermittent Hypoxia Training Alleviates the Damage of Sustained Normobaric Hypoxia on Human Hematological Indexes and Cerebral White Matter"],"prefix":"10.1177","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3623-9868","authenticated-orcid":false,"given":"Guangbo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurobiology, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China."},{"name":"Department of Brain Protection and Plasticity, Beijing Institute of Basic Medical Sciences, Beijing, China."},{"name":"Department of Neurology, Kangjixintu Hospital, Renqiu, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Brain Protection and Plasticity, Beijing Institute of Basic Medical Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengtao","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Air Force Medical Center, PLA, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Brain Protection and Plasticity, Beijing Institute of Basic Medical Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangpei","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Brain Protection and Plasticity, Beijing Institute of Basic Medical Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Brain Protection and Plasticity, Beijing Institute of Basic Medical Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Brain Protection and Plasticity, Beijing Institute of Basic Medical Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Brain Protection and Plasticity, Beijing Institute of Basic Medical Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China."},{"name":"Department of Brain Protection and Plasticity, Beijing Institute of Basic Medical Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Brain Protection and Plasticity, Beijing Institute of Basic Medical Sciences, Beijing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/CS20030161","article-title":"Intermittent altitude exposures reduce acute mountain sickness at 4300\u2009m","volume":"106","author":"Angela Navarrete-Opazo GSM","year":"2004","unstructured":"Angela Navarrete-Opazo GSM. 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