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Could orthostatic stress responses predict acute mountain sickness susceptibility before high altitude travel? A pilot study.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol<\/jats:italic>\n                    . 24:19\u201326, 2023.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>This study assessed head-up tilt (HUT) responses in relation to acute mountain sickness (AMS)-susceptibility during hypoxic exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Fifteen participants completed three lab visits: (1) protocol familiarization and cycle maximal oxygen consumption (VO\n                      <jats:sub>2<\/jats:sub>\n                      max) test; (2) HUT test consisting of supine rest for 20 minutes followed by 70\u00b0 tilting for \u226440 minutes; and (3) 6 hours of hypobaric hypoxic exposure (4,572\u2009m) where participants performed two 30-minute cycling bouts separated by 1 hour at a 50% VO\n                      <jats:sub>2<\/jats:sub>\n                      max workload within the first 3 hours and rested when not exercising. During HUT, systolic blood pressure (SBP), diastolic blood pressure, heart rate (HR), and variability (blood pressure variability [BPV] and HR variability [HRV]) were measured continuously. The AMS scores were determined after 6 hours of exposure. Correlations determined relationships between HUT cardiovascular responses and AMS scores. Repeated-measures analysis of variance (ANOVA) assessed differences between those with and without AMS symptoms during HUT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Higher AMS scores correlated with greater change in SBP variability (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.52,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.048) and blunted changes in HRV (root mean square of successive differences between normal heartbeats\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.81,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001, percentage of adjacent normal sinus intervals that differ by more than 50 milliseconds [pNN50]\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u20090.87,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) during HUT. A pNN50 interaction (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.02) suggested elevated cardiac sympathetic activity at baseline and a blunted increase in cardiac sympathetic influence throughout HUT in those with AMS (pNN50 baseline: AMS\u2009=\u200926.2%\u2009\u00b1\u200915.3%, no AMS\u2009=\u200951.0%\u2009\u00b1\u200913.5%; first 3 minutes into HUT: AMS\u2009=\u200917.2%\u2009\u00b1\u200919.1%, no AMS\u2009=\u200917.1%\u2009\u00b1\u200910.9%; end of HUT: AMS\u2009=\u20096.2%\u2009\u00b1\u20099.1%, no AMS 11.0%\u2009\u00b1\u200910.0%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The results suggest autonomic responses via HUT differ in AMS-susceptible individuals. Changes in HRV and BPV during HUT may be a promising predictive measurement for AMS-susceptibility, but further research is needed for confirmation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ham.2021.0177","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T17:03:54Z","timestamp":1670346234000},"page":"19-26","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Could Orthostatic Stress Responses Predict Acute Mountain Sickness Susceptibility Prior to High Altitude Travel? A Pilot Study"],"prefix":"10.1177","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0955-7625","authenticated-orcid":false,"given":"Bryanne N.","family":"Bellovary","sequence":"first","affiliation":[{"name":"Kinesiology Department, State University of New York at Cortland, Cortland, New York, USA."},{"name":"Department of Health, Exercise, and Sport Sciences, University of New Mexico, Albuquerque, New Mexico, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Wells","sequence":"additional","affiliation":[{"name":"Department of Health, Exercise, and Sport Sciences, University of New Mexico, Albuquerque, New Mexico, USA."},{"name":"Department of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary J.","family":"Fennel","sequence":"additional","affiliation":[{"name":"Department of Health, Exercise, and Sport Sciences, University of New Mexico, Albuquerque, New Mexico, USA."},{"name":"Molecular Medicine Program, University of Utah, Salt Lake City, Utah, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy B.","family":"Ducharme","sequence":"additional","affiliation":[{"name":"Department of Health, Exercise, and Sport Sciences, University of New Mexico, Albuquerque, New Mexico, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.","family":"Houck","sequence":"additional","affiliation":[{"name":"Department of Health, Exercise, and Sport Sciences, University of New Mexico, Albuquerque, New Mexico, USA."},{"name":"Department of Science, Husson University, Bangor, Maine, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor J.","family":"Mayschak","sequence":"additional","affiliation":[{"name":"Department of Health, Exercise, and Sport Sciences, University of New Mexico, Albuquerque, New Mexico, USA."},{"name":"Department of Emergency Medicine, University of New Mexico, Albuquerque, New Mexico, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann L.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Health, Exercise, and Sport Sciences, University of New Mexico, Albuquerque, New Mexico, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott N.","family":"Drum","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Northern Arizona University, Flagstaff, Arizona, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M.","family":"Mermier","sequence":"additional","affiliation":[{"name":"Department of Health, Exercise, and Sport Sciences, University of New Mexico, Albuquerque, New Mexico, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0838.2008.00827.x","article-title":"General introduction to altitude adaptation and mountain sickness: Altitude adaptation and mountain sickness","volume":"18","author":"B\u00e4rtsch P","year":"2008","unstructured":"B\u00e4rtsch P, , Saltin B. 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