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Impact of oxygen supplementation on brachial artery hemodynamics and vascular function during ascent to 5,050\u2009m.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol<\/jats:italic>\n                    . 24:27\u201336, 2023.\u2014High-altitude trekking alters upper limb hemodynamics and reduces brachial artery vascular function in lowlanders. Whether these changes are reversible with the removal of hypoxia is unknown. We investigated the impact of 20 minutes of oxygen supplementation (O\n                    <jats:sub>2<\/jats:sub>\n                    ) on brachial artery hemodynamics, reactive hyperemia (RH; microvascular function), and flow-mediated dilation (FMD; endothelial function). Participants (aged 21\u201342 years) were examined before and with O\n                    <jats:sub>2<\/jats:sub>\n                    at 3,440\u2009m (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20097), 4,371\u2009m (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20097), and 5,050\u2009m (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200912) using Duplex ultrasound (days 4, 7, and 10 respectively). At 3,440\u2009m, O\n                    <jats:sub>2<\/jats:sub>\n                    decreased brachial artery diameter (\u22125%\u2009\u00b1\u20095%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.04), baseline blood flow (\u221244%\u2009\u00b1\u200915%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), oxygen delivery (\u221239\u2009\u00b1\u200916;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and peak RH (\u22128%\u2009\u00b1\u20098%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.02), but not RH normalized for baseline blood flow. Elevated FMD (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.04) with O\n                    <jats:sub>2<\/jats:sub>\n                    at 3,440\u2009m was attributed to the reduction in baseline diameter. At 5,050\u2009m, a reduction in brachial artery blood flow (\u221217%\u2009\u00b1\u200922%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.03), but not oxygen delivery, diameter, RH, or FMD occurred with O\n                    <jats:sub>2<\/jats:sub>\n                    . These findings suggest that during early trekking at high altitude, O\n                    <jats:sub>2<\/jats:sub>\n                    causes vasoconstriction in the upper limb along the arterial tree (conduit and resistance arteries). With incremental high-altitude exposure, O\n                    <jats:sub>2<\/jats:sub>\n                    reduces blood flow without compromising oxygen delivery, RH, or FMD, suggesting a differential impact on vascular function modulated by the duration and severity of high-altitude exposure.\n                  <\/jats:p>","DOI":"10.1089\/ham.2022.0107","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T12:29:45Z","timestamp":1679315385000},"page":"27-36","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Oxygen Supplementation on Brachial Artery Hemodynamics and Vascular Function During Ascent to 5,050\u2009m"],"prefix":"10.1177","volume":"24","author":[{"given":"Gustavo A.","family":"Vizcardo-Galindo","sequence":"first","affiliation":[{"name":"Centre for Heart, Lung &amp; Vascular Health, Faculty of Health and Social Development, University of British Columbia\u2014Okanagan, Kelowna, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connor A.","family":"Howe","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung &amp; Vascular Health, Faculty of Health and Social Development, University of British Columbia\u2014Okanagan, Kelowna, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan L.","family":"Hoiland","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung &amp; Vascular Health, Faculty of Health and Social Development, University of British Columbia\u2014Okanagan, Kelowna, Canada."},{"name":"Department of Anesthesiology, Pharmacology and Therapeutics, Vancouver General Hospital, University of British Columbia, Vancouver, Canada."},{"name":"Department of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada."},{"name":"International Collaboration on Repair Discoveries, Vancouver, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard H.","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark."},{"name":"Cardiovascular Research Group, School of Human Sciences (Exercise and Sport Science), University of Western Australia, Perth, Australia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher K.","family":"Willie","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung &amp; Vascular Health, Faculty of Health and Social Development, University of British Columbia\u2014Okanagan, Kelowna, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip N.","family":"Ainslie","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung &amp; Vascular Health, Faculty of Health and Social Development, University of British Columbia\u2014Okanagan, Kelowna, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1667-294X","authenticated-orcid":false,"given":"Joshua C.","family":"Tremblay","sequence":"additional","affiliation":[{"name":"Centre for Heart, Lung &amp; Vascular Health, Faculty of Health and Social Development, University of British Columbia\u2014Okanagan, Kelowna, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.11.027"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2015.08.006"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.650796"},{"key":"e_1_3_5_5_1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects Models Usinglme4","volume":"67","author":"Bates D","year":"2015","unstructured":"Bates D, , M\u00e4chler M, , Bolker B, , and Walker S. 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