{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:58:31Z","timestamp":1792151911172,"version":"4.4.0"},"reference-count":81,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"published-print":{"date-parts":[[2023,3,1]]},"abstract":"<jats:p>\n                    Doherty, Connor J., Jou-Chung Chang, Benjamin P. Thompson, Erik R. Swenson, Glen E. Foster, and Paolo B. Dominelli. The impact of acetazolamide and methazolamide on exercise performance in normoxia and hypoxia.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol<\/jats:italic>\n                    . 24:7\u201318, 2023.\u2014Carbonic anhydrase (CA) inhibitors are commonly prescribed for acute mountain sickness (AMS). In this review, we sought to examine how two CA inhibitors, acetazolamide (AZ) and methazolamide (MZ), affect exercise performance in normoxia and hypoxia. First, we briefly describe the role of CA inhibition in facilitating the increase in ventilation and arterial oxygenation in preventing and treating AMS. Next, we detail how AZ affects exercise performance in normoxia and hypoxia and this is followed by a discussion on MZ. We emphasize that the overarching focus of the review is how the two drugs potentially affect exercise performance, rather than their ability to prevent\/treat AMS\n                    <jats:italic toggle=\"yes\">per se<\/jats:italic>\n                    , their interrelationship will be discussed. Overall, we suggest that AZ hinders exercise performance in normoxia, but may be beneficial in hypoxia. Based upon head-to-head studies of AZ and MZ in humans on diaphragmatic and locomotor strength in normoxia, MZ may be a better CA inhibitor when exercise performance is crucial at high altitude.\n                  <\/jats:p>","DOI":"10.1089\/ham.2022.0134","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T10:25:07Z","timestamp":1676975107000},"page":"7-18","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["The Impact of Acetazolamide and Methazolamide on Exercise Performance in Normoxia and Hypoxia"],"prefix":"10.1177","volume":"24","author":[{"given":"Connor J.","family":"Doherty","sequence":"first","affiliation":[{"name":"Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jou-Chung","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin P.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik R.","family":"Swenson","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Washington, USA."},{"name":"Medical Service, VA Puget Sound Health Care System, Seattle, Washington, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen E.","family":"Foster","sequence":"additional","affiliation":[{"name":"School of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5575-4043","authenticated-orcid":false,"given":"Paolo B.","family":"Dominelli","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"issue":"1","key":"e_1_3_4_2_1","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1152\/japplphysiol.01596.2005","article-title":"Effects of arterial oxygen content on peripheral locomotor muscle fatigue","volume":"101","author":"Amann M","year":"2006","unstructured":"Amann M, , Romer LM, , Pegelow DF, et al. 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