{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:59:54Z","timestamp":1789181994654,"version":"build-2803163510"},"reference-count":48,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:p>\n                    Sharma, Narendra Kumar, Mansi Srivastava, Tikam Chand Dakal, Vipin Ranga, and Pawan Kumar Maurya. Acute hypobaric hypoxia causes alterations in acetylcholine-mediated signaling through varying expression of muscarinic receptors in the prefrontal cortex and cerebellum of rats\u2019 brain.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol.<\/jats:italic>\n                    26:156\u2013164, 2025.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Muscarinic receptor (CHRM) proteins are G-protein-associated acetylcholine receptors found in neuronal membranes. Five major subtypes, CHRM1\u2013CHRM5, modulate acetylcholine in central nervous system signaling cascades. CHRM1, CHRM3, and CHRM5 are linked to G\u03b1q\/G\u03b111 proteins, whereas CHRM2 and CHRM4 are linked to G\u03b1i\/G\u03b1o proteins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Limited research has been conducted to explore the impact of HH on CHRM gene expressions. It is caused by low oxygen availability at high altitudes, which impairs neurotransmission, cognitive performance, and physiological functions. Previous studies have shown that exposure to hypoxia leads to a reduction in CHRM receptors, which in turn causes alteration in signal transduction, physiological responses, cognitive deficits, and mood alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>In the present study, we have used semiquantitative PCR to measure muscarinic receptor gene expression after 6, 12, and 24 hours of HH exposure at 25,000 feet using a decompression chamber in rat brain\u2019s PFC and cerebellum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>We have found that CHRM1\u2013CHRM5 downregulated after acute exposure to hypoxia until 12 hours, and then, the expression level of these receptors increased to 24 hours when compared with 12 hours in PFC. All subtypes have shown a similar pattern in PFC regions under hypoxia exposure. On the other hand, these receptors have shown altered expression at different time points in the cerebellum. CHRM1 and CHRM4 acutely downregulated, CHRM2 and CHRM5 downregulated, while CHRM3 upregulated after hypoxia exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our study, for the first time, has shown the altered expressions of muscarinic receptors under temporal hypoxia exposure. The altered expression pattern has shown an association with acclimatization and protection against necrosis due to hypoxia. This study may pave further investigations for understanding and addressing the cognitive, behavioral, and physiological impacts of hypoxia and therapeutic development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ham.2023.0146","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T20:08:06Z","timestamp":1728418086000},"page":"156-164","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute Hypobaric Hypoxia Causes Alterations in Acetylcholine-Mediated Signaling Through Varying Expression of Muscarinic Receptors in the Prefrontal Cortex and Cerebellum of Rats\u2019 Brain"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8681-3840","authenticated-orcid":false,"given":"Narendra Kumar","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Bioscience and Biotechnology, Banasthali Vidyapith, Tonk, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Bioscience and Biotechnology, Banasthali Vidyapith, Tonk, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tikam Chand","family":"Dakal","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Genome and Computational Biology Lab, Mohanlal Sukhadia University, Udaipur, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipin","family":"Ranga","sequence":"additional","affiliation":[{"name":"DBT-NECAB, Assam Agricultural University, Jorhat, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan Kumar","family":"Maurya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Central University of Haryana, Mahendergarh, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2016.05.011"},{"key":"e_1_3_3_3_1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.neuropharm.2017.09.024","article-title":"Allosteric modulators targeting CNS muscarinic receptors","volume":"136","author":"Bock A","year":"2018","unstructured":"Bock A, , Schrage R, , Mohr K. Allosteric modulators targeting CNS muscarinic receptors. Neuropharmacology, 2018; 136(Pt C):427\u2013437; doi: 10.1016\/j.neuropharm.2017.09.024","journal-title":"Neuropharmacology"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101343"},{"key":"e_1_3_3_5_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.pharmtox.010909.105741","article-title":"Allosteric receptors: From electric organ to cognition","volume":"50","author":"Changeux JP","year":"2010","unstructured":"Changeux JP. Allosteric receptors: From electric organ to cognition. Annu Rev Pharmacol Toxicol, 2010; 50:1\u201338; doi: 10.1146\/annurev.pharmtox.010909.105741","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11884-023-00690-x"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-020-09465-1"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.09.008"},{"key":"e_1_3_3_9_1","doi-asserted-by":"crossref","first-page":"1124333","DOI":"10.3389\/fncel.2023.1124333","article-title":"A growing understanding of the role of muscarinic receptors in the molecular pathology and treatment of schizophrenia","volume":"17","author":"Dean B","year":"2023","unstructured":"Dean B, , Bakker G, , Ueda HR, et al. A growing understanding of the role of muscarinic receptors in the molecular pathology and treatment of schizophrenia. Front Cell Neurosci, 2023; 17:1124333; doi: 10.3389\/fncel.2023.1124333","journal-title":"Front Cell Neurosci"},{"issue":"6","key":"e_1_3_3_10_1","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/ajmg.b.32440","article-title":"COMT genotype is associated with differential expression of muscarinic M1 receptors in human cortex","volume":"171","author":"Dean B","year":"2016","unstructured":"Dean B, , Scarr E. COMT genotype is associated with differential expression of muscarinic M1 receptors in human cortex. Am J Med Genet B Neuropsychiatr Genet, 2016; 171(6):784\u2013789; doi: 10.1002\/ajmg.b.32440","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-8673.2006.00368.x"},{"issue":"1","key":"e_1_3_3_12_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1523\/JNEUROSCI.22-01-j0001.2002","article-title":"M5 muscarinic receptors are required for prolonged accumbal dopamine release after electrical stimulation of the pons in mice","volume":"22","author":"Forster GL","year":"2002","unstructured":"Forster GL, , Yeomans JS, , Takeuchi J, et al. M5 muscarinic receptors are required for prolonged accumbal dopamine release after electrical stimulation of the pons in mice. J Neurosci, 2002; 22(1):RC190; doi: 10.1523\/JNEUROSCI.22-01-j0001.2002","journal-title":"J Neurosci"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01132-0"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00484-020-02037-1"},{"issue":"3","key":"e_1_3_3_15_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jad.2008.11.015","article-title":"Decreased muscarinic receptor binding in the frontal cortex of bipolar disorder and major depressive disorder subjects","volume":"116","author":"Gibbons AS","year":"2009","unstructured":"Gibbons AS, , Scarr E, , McLean C, et al. Decreased muscarinic receptor binding in the frontal cortex of bipolar disorder and major depressive disorder subjects. J Affect Disord, 2009; 116(3):184\u2013191; doi: 10.1016\/j.jad.2008.11.015","journal-title":"J Affect Disord"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713001529"},{"issue":"3","key":"e_1_3_3_17_1","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1002\/jcb.29483","article-title":"Chrm3 protects against acinar cell necrosis by stabilizing caspase-8 expression in severe acute pancreatitis mice model","volume":"121","author":"Huang N","year":"2020","unstructured":"Huang N, , Murtaza G, , Wang L, et al. Chrm3 protects against acinar cell necrosis by stabilizing caspase-8 expression in severe acute pancreatitis mice model. J Cell Biochem, 2020; 121(3):2618\u20132631; doi: 10.1002\/jcb.29483","journal-title":"J Cell Biochem"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-022-01715-2"},{"issue":"1","key":"e_1_3_3_19_1","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/s41398-023-02400-x","article-title":"Cross-diagnostic determinants of cognitive functioning: The muscarinic cholinergic receptor as a model system","volume":"13","author":"Jones SE","year":"2023","unstructured":"Jones SE, , Harvey PD. Cross-diagnostic determinants of cognitive functioning: The muscarinic cholinergic receptor as a model system. Transl Psychiatry, 2023; 13(1):100; doi: 10.1038\/s41398-023-02400-x","journal-title":"Transl Psychiatry"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.06.023"},{"issue":"12","key":"e_1_3_3_21_1","doi-asserted-by":"crossref","first-page":"009621","DOI":"10.1101\/cshperspect.a009621","article-title":"Functional neuroanatomy of the basal ganglia","volume":"2","author":"Lanciego JL","year":"2012","unstructured":"Lanciego JL, , Luquin N, , Obeso JA. Functional neuroanatomy of the basal ganglia. Cold Spring Harb Perspect Med, 2012; 2(12):a009621.","journal-title":"Cold Spring Harb Perspect Med"},{"key":"e_1_3_3_22_1","doi-asserted-by":"crossref","first-page":"103254","DOI":"10.1016\/j.resp.2019.103254","article-title":"M4-muscarinic acetylcholine receptor into the pedunculopontine tegmental nucleus mediates respiratory modulation of conscious rats","volume":"269","author":"Lima JD","year":"2019","unstructured":"Lima JD, , Sobrinho CR, , Santos LK, et al. M4-muscarinic acetylcholine receptor into the pedunculopontine tegmental nucleus mediates respiratory modulation of conscious rats. Respir Physiol Neurobiol, 2019; 269:103254; doi: 10.1016\/j.resp.2019.103254","journal-title":"Respir Physiol Neurobiol"},{"issue":"8","key":"e_1_3_3_23_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/ajpcell.00265.2015","article-title":"Oxygen sensing by the carotid body: Mechanisms and role in adaptation to hypoxia","volume":"310","author":"Lopez-Barneo J","year":"2016","unstructured":"Lopez-Barneo J, , Gonzalez-Rodriguez P, , Gao L, et al. Oxygen sensing by the carotid body: Mechanisms and role in adaptation to hypoxia. Am J Physiol Cell Physiol, 2016; 310(8):C629\u2013C642; doi: 10.1152\/ajpcell.00265.2015","journal-title":"Am J Physiol Cell Physiol"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2021.173184"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119886"},{"issue":"1","key":"e_1_3_3_26_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuron.2012.08.036","article-title":"Acetylcholine as a neuromodulator: Cholinergic signaling shapes nervous system function and behavior","volume":"76","author":"Picciotto MR","year":"2012","unstructured":"Picciotto MR, , Higley MJ, , Mineur YS. Acetylcholine as a neuromodulator: Cholinergic signaling shapes nervous system function and behavior. Neuron, 2012; 76(1):116\u2013129; doi: 10.1016\/j.neuron.2012.08.036","journal-title":"Neuron"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137558"},{"issue":"1","key":"e_1_3_3_28_1","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci13010108","article-title":"Influence of sex and muscarinic activity on memory retrieval in mouse model of traumatic brain injury","volume":"13","author":"Rashid H","year":"2023","unstructured":"Rashid H, , Ahmed T. Influence of sex and muscarinic activity on memory retrieval in mouse model of traumatic brain injury. Brain Sci, 2023; 13(1); doi: 10.3390\/brainsci13010108","journal-title":"Brain Sci"},{"issue":"36","key":"e_1_3_3_29_1","doi-asserted-by":"crossref","first-page":"6917","DOI":"10.1523\/JNEUROSCI.1424-21.2022","article-title":"Chronic loss of muscarinic M5 receptor function manifests disparate impairments in exploratory behavior in male and female mice despite common dopamine regulation","volume":"42","author":"Razidlo JA","year":"2022","unstructured":"Razidlo JA, , Fausner SML, , Ingebretson AE, et al. Chronic loss of muscarinic M5 receptor function manifests disparate impairments in exploratory behavior in male and female mice despite common dopamine regulation. J Neurosci, 2022; 42(36):6917\u20136930; doi: 10.1523\/JNEUROSCI.1424-21.2022","journal-title":"J Neurosci"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1244"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00388"},{"issue":"3","key":"e_1_3_3_32_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2741\/4727","article-title":"Cerebral ischemic stroke: Cellular fate and therapeutic opportunities","volume":"24","author":"Sarkar S","year":"2019","unstructured":"Sarkar S, , Chakraborty D, , Bhowmik A, et al. Cerebral ischemic stroke: Cellular fate and therapeutic opportunities. Front Biosci (Landmark Ed), 2019; 24(3):435\u2013450; doi: 10.2741\/4727","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"3","key":"e_1_3_3_33_1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s12031-014-0381-9","article-title":"Protein profiling reveals antioxidant and signaling activities of NAP (Davunetide) in rodent hippocampus exposed to hypobaric hypoxia","volume":"54","author":"Sethy NK","year":"2014","unstructured":"Sethy NK, , Sharma NK, , Das M, et al. Protein profiling reveals antioxidant and signaling activities of NAP (Davunetide) in rodent hippocampus exposed to hypobaric hypoxia. J Mol Neurosci, 2014; 54(3):414\u2013429.","journal-title":"J Mol Neurosci"},{"key":"e_1_3_3_34_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-981-19-1008-1","volume-title":"High Altitude Sickness\u2013Solutions from Genomics, Proteomics and Antioxidant Interventions","author":"Sharma NK","year":"2022","unstructured":"Sharma NK, , Arya A. High Altitude Sickness\u2013Solutions from Genomics, Proteomics and Antioxidant Interventions. Springer; 2022."},{"key":"e_1_3_3_35_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-981-19-1008-1","volume-title":"High Altitude Sickness\u2013Solutions from Genomics, Proteomics and Antioxidant Interventions","author":"Sharma P","year":"2022","unstructured":"Sharma P, , Pandey P, , Kumari P, et al. Introduction to high altitude and hypoxia. In: High Altitude Sickness\u2013Solutions from Genomics, Proteomics and Antioxidant Interventions. Springer: 2022; pp. 1\u201317."},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2012.12.020"},{"issue":"3","key":"e_1_3_3_37_1","first-page":"217","article-title":"Proteomic evaluation of antioxidant activities of nap peptide in rat brain cortex exposed to chronic hypobaric hypoxia","volume":"3","author":"Sharma NK","year":"2012","unstructured":"Sharma NK, , Sethy NK, , Das M, et al. Proteomic evaluation of antioxidant activities of nap peptide in rat brain cortex exposed to chronic hypobaric hypoxia. Journal of Proteins and Proteomics, 2012; 3(3):217\u2013228.","journal-title":"Journal of Proteins and Proteomics"},{"issue":"3","key":"e_1_3_3_38_1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1152\/ajplung.00467.2018","article-title":"Distinct pathways to the parafacial respiratory group to trigger active expiration in adult rats","volume":"317","author":"Silva JN","year":"2019","unstructured":"Silva JN, , Oliveira LM, , Souza FC, et al. Distinct pathways to the parafacial respiratory group to trigger active expiration in adult rats. Am J Physiol Lung Cell Mol Physiol, 2019; 317(3):L402\u2013L413; doi: 10.1152\/ajplung.00467.2018","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"e_1_3_3_39_1","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1038\/s41598-022-07616-3","article-title":"Biomechanical and structural responses of the aorta to intermittent hypobaric hypoxia in a rat model","volume":"12","author":"Utrera A","year":"2022","unstructured":"Utrera A, , Navarrete A, , Gonzalez-Candia A, et al. Biomechanical and structural responses of the aorta to intermittent hypobaric hypoxia in a rat model. Sci Rep, 2022; 12(1):3790; doi: 10.1038\/s41598-022-07616-3","journal-title":"Sci Rep"},{"issue":"8","key":"e_1_3_3_40_1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/jphp.12919","article-title":"Muscarinic and nicotinic acetylcholine receptor agonists: Current scenario in Alzheimer\u2019s disease therapy","volume":"70","author":"Verma S","year":"2018","unstructured":"Verma S, , Kumar A, , Tripathi T, et al. Muscarinic and nicotinic acetylcholine receptor agonists: Current scenario in Alzheimer\u2019s disease therapy. J Pharm Pharmacol, 2018; 70(8):985\u2013993; doi: 10.1111\/jphp.12919","journal-title":"J Pharm Pharmacol"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(03)45003-6"},{"key":"e_1_3_3_42_1","article-title":"Targeting muscarinic receptors for the treatment of alcohol use disorders: Opportunities and hurdles for clinical development","author":"Walker LC","year":"2023","unstructured":"Walker LC, , Huckstep KL, , Becker HC, et al. Targeting muscarinic receptors for the treatment of alcohol use disorders: Opportunities and hurdles for clinical development. Br J Pharmacol, 2023; doi: 10.1111\/bph.16081","journal-title":"Br J Pharmacol"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.04.001"},{"issue":"7","key":"e_1_3_3_44_1","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1017\/S0033291716000167","article-title":"The CHRM3 gene is implicated in abnormal thalamo-orbital frontal cortex functional connectivity in first-episode treatment-naive patients with schizophrenia","volume":"46","author":"Wang Q","year":"2016","unstructured":"Wang Q, , Cheng W, , Li M, et al. The CHRM3 gene is implicated in abnormal thalamo-orbital frontal cortex functional connectivity in first-episode treatment-naive patients with schizophrenia. Psychol Med, 2016; 46(7):1523\u20131534; doi: 10.1017\/S0033291716000167","journal-title":"Psychol Med"},{"issue":"1","key":"e_1_3_3_45_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/s41392-023-01427-2","article-title":"G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders","volume":"8","author":"Wong TS","year":"2023","unstructured":"Wong TS, , Li G, , Li S, et al. G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders. Signal Transduct Target Ther, 2023; 8(1):177; doi: 10.1038\/s41392-023-01427-2","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"e_1_3_3_46_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0166-2236(96)10073-4","article-title":"Presynaptic nicotinic ACh receptors","volume":"20","author":"Wonnacott S","year":"1997","unstructured":"Wonnacott S. Presynaptic nicotinic ACh receptors. Trends Neurosci, 1997; 20(2):92\u201398; doi: 10.1016\/s0166-2236(96)10073-4","journal-title":"Trends Neurosci"},{"key":"e_1_3_3_47_1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.neuroscience.2020.06.006","article-title":"Cholinergic and adenosinergic modulation of synaptic release","volume":"456","author":"Yang D","year":"2021","unstructured":"Yang D, , Ding C, , Qi G, et al. Cholinergic and adenosinergic modulation of synaptic release. Neuroscience, 2021; 456:114\u2013130.","journal-title":"Neuroscience"},{"issue":"4","key":"e_1_3_3_48_1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1007\/s11064-015-1755-2","article-title":"Role of muscarinic acetylcholine receptor-2 in the cerebellar cortex in cardiovascular modulation in anaesthetized rats","volume":"41","author":"Zhang C","year":"2016","unstructured":"Zhang C, , Sun T, , Zhou P, et al. Role of muscarinic acetylcholine receptor-2 in the cerebellar cortex in cardiovascular modulation in anaesthetized rats. Neurochem Res, 2016; 41(4):804\u2013812; doi: 10.1007\/s11064-015-1755-2","journal-title":"Neurochem Res"},{"issue":"15","key":"e_1_3_3_49_1","doi-asserted-by":"crossref","first-page":"6347","DOI":"10.1523\/JNEUROSCI.22-15-06347.2002","article-title":"Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice","volume":"22","author":"Zhang W","year":"2002","unstructured":"Zhang W, , Yamada M, , Gomeza J, et al. Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice. J Neurosci, 2002; 22(15):6347\u20136352; doi: 10.1523\/JNEUROSCI.22-15-06347.2002","journal-title":"J Neurosci"}],"container-title":["High Altitude Medicine &amp; Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1089\/ham.2023.0146","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ham.2023.0146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1089\/ham.2023.0146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:25:44Z","timestamp":1777447544000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1089\/ham.2023.0146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,26]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,6,1]]}},"alternative-id":["10.1089\/ham.2023.0146"],"URL":"https:\/\/doi.org\/10.1089\/ham.2023.0146","relation":{},"ISSN":["1527-0297","1557-8682"],"issn-type":[{"value":"1527-0297","type":"print"},{"value":"1557-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,26]]}}}