{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:00:44Z","timestamp":1789621244808,"version":"build-2803163510"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:p>\n                    H\u00e4fliger, Alina, Aline Buergin, Laura C. Mayer, Maamed Mademilov, Mona Lichtblau, Talantbek Sooronbaev, Silvia Ulrich, Konrad E. Bloch, and Michael Furian. Sex-specific difference in health-related altitude-effects and their prevention by acetazolamide. Data from a randomized controlled trial.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol.<\/jats:italic>\n                    26:195\u2013203, 2025.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Women are underrepresented in studies on acute mountain sickness (AMS), altitude-induced sleep-disordered breathing and preventive acetazolamide use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We analyzed sex-specific altitude-effects in participants of a randomized, placebo-controlled, double-blind trial in healthy lowlanders &gt;40 years. Participants took 375 mg\/day acetazolamide or placebo starting 24 hours before ascent to and while staying 2 days at 3,100 m. Main outcomes of this analysis were sex-specific incidence of AMS (Lake Louise score \u22653), nocturnal pulse oximetry (SpO\n                      <jats:sub>2<\/jats:sub>\n                      ) and apnea\u2013hypopnea index (AHI) at 3,100 m.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      With placebo, 30 of 119 (25%) women and 4 of 51 (8%) men developed AMS (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.009 between sexes) at 3,100 m. Among women assigned to placebo, SpO\n                      <jats:sub>2<\/jats:sub>\n                      (mean \u00b1 SE 84 \u00b1 0%) and AHI (16.9 \u00b1 1.3\/h) in night 1 at 3,100 m were lower compared to men (SpO\n                      <jats:sub>2<\/jats:sub>\n                      86 \u00b1 0%; AHI 28.3\u2009\u00b1\u20091.9\/h), despite similar baseline values at 760 m. Mean between-sex difference in altitude-effects (women-men) in SpO\n                      <jats:sub>2<\/jats:sub>\n                      was \u22121.4% (95% CI, \u22122.4 to \u22120.3%); AHI \u221210.7\/h (95% CI, \u221215.7 to \u22125.7\/h). The impact of acetazolamide on AMS was not significant for either sex but acetazolamide improved AHI in men (difference men-women, \u22129.8\/h [95% CI, \u221216.8 to \u22122.7\/h]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study suggests sex-specific differences in altitude-induced hypoxemia, periodic breathing, AMS incidence, and in the response to preventive acetazolamide treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ham.2024.0011","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T20:11:46Z","timestamp":1736367106000},"page":"195-203","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Sex-Specific Difference in Health-Related Altitude-Effects and Their Prevention by Acetazolamide. Data from a Randomized Controlled Trial"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2182-4203","authenticated-orcid":false,"given":"Alina","family":"H\u00e4fliger","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Buergin","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maamed","family":"Mademilov","sequence":"additional","affiliation":[{"name":"National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyzstan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4485-1758","authenticated-orcid":false,"given":"Mona","family":"Lichtblau","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talantbek","family":"Sooronbaev","sequence":"additional","affiliation":[{"name":"National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyzstan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5250-5022","authenticated-orcid":false,"given":"Silvia","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2377-7387","authenticated-orcid":false,"given":"Konrad E.","family":"Bloch","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital Zurich, Zurich, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8518-5029","authenticated-orcid":false,"given":"Michael","family":"Furian","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital Zurich, Zurich, Switzerland."},{"name":"Research Department, Swiss University of Traditional Chinese Medicine, Bad Zurzach, Switzerland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet127"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2008.06.006"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14024"},{"issue":"1","key":"e_1_3_6_5_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1378\/chest.14-0317","article-title":"Sex and acetazolamide effects on chemoreflex and periodic breathing during sleep at altitude","volume":"147","author":"Caravita S","year":"2015","unstructured":"Caravita S, , Faini A, , Lombardi C, et al. 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