{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:09:48Z","timestamp":1787008188027,"version":"build-2736575974"},"reference-count":27,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:p>\n                    Ren, Hong, Xi-Yue Yang, Rui Su, HaiLin Ma, and Hao Li. Temporal effects of hypoxia exposure at high altitudes on compensatory brain function: evidence from functional connectivity of resting-state EEG brain networks.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol.<\/jats:italic>\n                    26:165\u2013174, 2025.\n                  <\/jats:p>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the effects of prolonged exposure to hypobaric hypoxia at high altitude on changes in brain function measured by electroencephalography (EEG), focusing specifically on the resting-state brain network functional connectivity and compensatory adaptations in brain function among individuals with varying durations of high altitude residency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In study I, 64 participants were divided into high-altitude group (HG) and low-altitude group (LG). Ninety-six long-term migrants residing at an altitude of 3,650 m were recruited for studyII and categorized into three groups based on their duration of stay at high altitude: group A (1\u20132 years), group B (8\u201310 years), and group C (18\u201320 years). Resting-state EEG data were collected from each participant, and functional connectivity analysis was conducted using Phase Locking Value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Study I showed that participants with HG had stronger functional connectivity in the occipital lobe than those with LG (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05). The study II findings indicate that there were significant differences in functional connectivity strength among the frontal and occipital lobes in groups A, B, and C across the \u03b1, \u03b2, \u03b4, and \u03b8 frequency bands. Specifically, the functional connectivity strength of the frontal lobe was significantly higher in group A compared with group B, and in group B compared with group C (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05). Additionally, the functional connectivity of the occipital lobe was significantly higher in group C compared with group B, and in group B compared with group A (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The consistent results of the whole frequency band suggest that the individual\u2019s occipital lobe function is enhanced to compensate for the damage of frontal lobe function, so as to better adapt to the extreme environment at high altitude.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1089\/ham.2024.0063","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T19:05:48Z","timestamp":1734462348000},"page":"165-174","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Temporal Effects of Hypoxia Exposure at High Altitudes on Compensatory Brain Function: Evidence from Functional Connectivity of Resting-State EEG Brain Networks"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6814-1494","authenticated-orcid":false,"given":"Hong","family":"Ren","sequence":"first","affiliation":[{"name":"Tibet Autonomous Region Key Laboratory for High Altitude Brain Science and Environmental Adaptation, Tibet University, Lhasa, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-Yue","family":"Yang","sequence":"additional","affiliation":[{"name":"Tibet Autonomous Region Key Laboratory for High Altitude Brain Science and Environmental Adaptation, Tibet University, Lhasa, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8104-9145","authenticated-orcid":false,"given":"Rui","family":"Su","sequence":"additional","affiliation":[{"name":"Tibet Autonomous Region Key Laboratory for High Altitude Brain Science and Environmental Adaptation, Tibet University, Lhasa, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaiLin","family":"Ma","sequence":"additional","affiliation":[{"name":"Tibet Autonomous Region Key Laboratory for High Altitude Brain Science and Environmental Adaptation, Tibet University, Lhasa, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[{"name":"Tibet Autonomous Region Key Laboratory for High Altitude Brain Science and Environmental Adaptation, Tibet University, Lhasa, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"issue":"11","key":"e_1_3_6_2_1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.3357\/AMHP.6061.2022","article-title":"Attention network changes of high-altitude migrants","volume":"93","author":"An X","year":"2022","unstructured":"An X, , Tao G, , Zhang X, et al. 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