{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:48:46Z","timestamp":1791600526843,"version":"4.3.4"},"reference-count":82,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["High Altitude Medicine &amp; Biology"],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:p>\n                    Yunden Droma, Masao Ota, Nobumitsu Kobayashi, Michiko Ito, Toshio Kobayashi, and Masayuki Hanaoka. Genetic associations with the susceptibility to high-altitude Pulmonary Edema in the Japanese population.\n                    <jats:italic toggle=\"yes\">High Alt Med Biol.<\/jats:italic>\n                    26:215\u2013226, 2025.\u2014High-altitude pulmonary edema (HAPE) is a life-threatening, noncardiogenic pulmonary condition that may occur in individuals rapidly ascending to altitudes higher than 2,500 m above sea level. Exaggerated hypoxia-induced pulmonary hypertension plays a critical role in its pathophysiological mechanism. In addition to environmental factors such as hypoxia and hypobaria at high altitudes, individual genetic predisposition significantly influences HAPE occurrence. Several candidate genes have been proposed based on the pathophysiology of HAPE, particularly involving the hypoxia-induced factor pathway and vasodilators\/vasoconstrictors. Over the past two decades, we have investigated the associations between susceptibility to HAPE and these candidate genes, including genes\n                    <jats:italic toggle=\"yes\">EPAS1<\/jats:italic>\n                    (endothelial Per-ARNT-Sim [PAS] domain protein 1),\n                    <jats:italic toggle=\"yes\">EGLN1<\/jats:italic>\n                    (egl-9 family hypoxia inducible factor 1),\n                    <jats:italic toggle=\"yes\">eNOS<\/jats:italic>\n                    (endothelial nitric oxide synthase),\n                    <jats:italic toggle=\"yes\">ACE<\/jats:italic>\n                    (angiotensin-converting enzyme), and\n                    <jats:italic toggle=\"yes\">TIMP3<\/jats:italic>\n                    (tissue inhibitor of metalloproteinase 3) in the Japanese population. This review summarizes the major findings of these studies, shedding light on genetic associations with HAPE in the Japanese population.\n                  <\/jats:p>","DOI":"10.1089\/ham.2024.0119","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T10:29:16Z","timestamp":1742207356000},"page":"215-226","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Genetic Associations with the Susceptibility to High-Altitude Pulmonary Edema in the Japanese Population"],"prefix":"10.1177","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2798-8816","authenticated-orcid":false,"given":"Yunden","family":"Droma","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ota","sequence":"additional","affiliation":[{"name":"Division of Hepatology and Gastroenterology, Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobumitsu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Ito","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kakeyu Misayama Rehabilitation Center, Ueda, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Hanaoka","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,5,26]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/7890188"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11332-020-00712-9"},{"issue":"11","key":"e_1_3_5_4_1","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1136\/thx.2004.029124","article-title":"eNOS allelic variants at the same locus associate with HAPE and adaptation","volume":"59","author":"Ahsan A","year":"2004","unstructured":"Ahsan A, , Charu R, , Pasha MAQ, et al. eNOS allelic variants at the same locus associate with HAPE and adaptation. 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