{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T12:47:18Z","timestamp":1774442838677,"version":"3.50.1"},"reference-count":59,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Gene Therapy Methods"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1089\/hgtb.2015.106","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T04:48:11Z","timestamp":1444884491000},"page":"17-31","source":"Crossref","is-referenced-by-count":33,"title":["Retroviral Replicating Vectors Deliver Cytosine Deaminase Leading to Targeted 5-Fluorouracil-Mediated Cytotoxicity in Multiple Human Cancer Types"],"prefix":"10.1177","volume":"27","author":[{"given":"Chris G.","family":"Twitty","sequence":"first","affiliation":[{"name":"Tocagen, Inc., San Diego, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar R.","family":"Diago","sequence":"additional","affiliation":[{"name":"Tocagen, Inc., San Diego, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Hogan","sequence":"additional","affiliation":[{"name":"Tocagen, Inc., San Diego, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Burrascano","sequence":"additional","affiliation":[{"name":"Tocagen, Inc., San Diego, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.","family":"Ibanez","sequence":"additional","affiliation":[{"name":"Tocagen, Inc., San Diego, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas J.","family":"Jolly","sequence":"additional","affiliation":[{"name":"Tocagen, Inc., San Diego, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Ostertag","sequence":"additional","affiliation":[{"name":"Tocagen, Inc., San Diego, California."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"B1","first-page":"561","volume":"127","author":"Dock G","year":"1904","journal-title":"Am J Med Sci"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1089\/104303401750195881"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nor199"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2013.51"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1089\/104303403321070810"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2014-708"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2012.83"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/46.2.171"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2011.01.013"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1074"},{"key":"B12","first-page":"658","volume":"63","author":"Zhang M","year":"2003","journal-title":"Cancer Res"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.2174\/0929867053363432"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2011.131"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2011.10.015"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.23.1.79"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2012.12"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000091"},{"key":"B19","first-page":"5276","volume":"46","author":"Moolten FL","year":"1986","journal-title":"Cancer Res"},{"key":"B20","doi-asserted-by":"crossref","first-page":"798","DOI":"10.3892\/ijo.2012.1523","volume":"41","author":"Yi B-R","year":"2012","journal-title":"Int J Oncol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041040305"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0151"},{"key":"B23","first-page":"3399","volume":"18","author":"Kuriyama S","year":"1998","journal-title":"Anticancer Res"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.17.8302"},{"key":"B25","first-page":"2241","volume":"27","author":"Tsujie M","year":"2007","journal-title":"Anticancer Res"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1089\/10430349950017356"},{"key":"B27","first-page":"2588","volume":"58","author":"Lawrence TS","year":"1998","journal-title":"Cancer Res"},{"key":"B28","first-page":"6847","volume":"63","author":"Ramnaraine M","year":"2003","journal-title":"Cancer Res"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.1239"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7701110"},{"key":"B31","unstructured":"GoodmanLS. Goodman and Gilman's the Pharmacological Basis of Therapeutics. (McGraw-Hill, New York, NY). 1996."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.2630"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2014.38"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.01.002"},{"key":"B35","doi-asserted-by":"crossref","first-page":"4112","DOI":"10.1016\/S0021-9258(20)64293-4","volume":"266","author":"Seither RL","year":"1991","journal-title":"J Biol Chem"},{"key":"B36","first-page":"35","volume-title":"Antifungal Chemotherapy","author":"Scholer HJ","year":"1980"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2006.12.020"},{"key":"B39","first-page":"773","volume":"62","author":"Miller CR","year":"2002","journal-title":"Cancer Res"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-010-0295-5"},{"key":"B41","first-page":"135","volume":"12","author":"Neal JW","year":"2014","journal-title":"Nat Pub Group"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2013.13"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-4-r36"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2450"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1177\/0962280211428386"},{"key":"B47","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1002\/j.1460-2075.1993.tb05858.x","volume":"12","author":"Roe T","year":"1993","journal-title":"EMBO J"},{"key":"B48","first-page":"1753","volume":"45","author":"Nishiyama T","year":"1985","journal-title":"Cancer Res"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206952"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2012.07.011"},{"key":"B51","first-page":"4363","volume":"9","author":"van Kuilenburg ABP","year":"2003","journal-title":"Clin Cancer Res"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-0169"},{"key":"B53","first-page":"4808","volume":"55","author":"Trinh QT","year":"1995","journal-title":"Cancer Res"},{"key":"B54","first-page":"9","volume":"28","author":"Guo X","year":"2008","journal-title":"Anticancer Res"},{"key":"B55","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1128\/JVI.68.1.510-516.1994","volume":"68","author":"Lewis PF","year":"1994","journal-title":"J Virol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.4161\/onci.27589"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-013-1434-6"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.1.110304.100043"},{"key":"B59","first-page":"1503","volume":"54","author":"Mullen CA","year":"1994","journal-title":"Cancer Res"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.4161\/onci.27359"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197907193010303"}],"container-title":["Human Gene Therapy Methods"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/hgtb.2015.106","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/hgtb.2015.106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T09:09:13Z","timestamp":1770714553000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/hgtb.2015.106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":59,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1089\/hgtb.2015.106"],"URL":"https:\/\/doi.org\/10.1089\/hgtb.2015.106","relation":{},"ISSN":["1946-6536","1946-6544"],"issn-type":[{"value":"1946-6536","type":"print"},{"value":"1946-6544","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2]]}}}