{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:27:46Z","timestamp":1777681666226,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Health Security"],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:p>Treatment of multisystem inflammatory syndrome in children (MIS-C) can require significant critical care resources. Our aim is to alert mixed pediatric and adult hospitals worldwide of the possibility that pediatric and adult patients may simultaneously require cannulation to extracorporeal membrane oxygenation (ECMO) for MIS-C and severe COVID-19. We conducted a retrospective review of operations required to treat cardiogenic shock in 3 pediatric patients with a diagnosis of MIS-C admitted to a single medium-sized pediatric referral center located within a large academic medical center over a 14-day period. At this time, a large number of adult patients required ECMO for severe COVID-19 at our institution. Of the 11 pediatric patients who presented with MIS-C during the first surge of 2020, 2 patients required cannulation to venoarterial extracorporeal membrane oxygenation (VA-ECMO), and a third patient developed a life-threatening arrhythmia requiring transfer to a neighboring institution for consideration of VA-ECMO when our institution's ECMO capacity had briefly been reached. Pediatric referral centers located within institutions providing ECMO to adult patients with severe COVID-19 may benefit from frequent and direct communication with their adult and regional colleagues to devise a collaborative plan for safe and timely provision of ECMO to patients with MIS-C as the ongoing pandemic continues to consume this limited, lifesaving resource.<\/jats:p>","DOI":"10.1089\/hs.2021.0119","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T12:21:26Z","timestamp":1641990086000},"page":"50-57","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Operational Innovation in the Provision of Pediatric Extracorporeal Membrane Oxygenation for Multisystem Inflammatory Syndrome in Children"],"prefix":"10.1177","volume":"20","author":[{"given":"Catherine E.","family":"Naber","sequence":"first","affiliation":[{"name":"Catherine E. Naber, MD, and Neil D. Fernandes, MD, are Pediatric Critical Care Fellows, Division of Pediatric Critical Care Medicine; Manuella Lahoud-Rahme, MD, is a Pediatric Cardiologist, Division of Pediatric Critical Care and Division of Pediatric Cardiology; Phoebe H. Yager, MD, is a Pediatric Critical Care Physician and Chief, Division of Pediatric Critical Care Medicine; Brian M. Cummings, MD, is Medical Director and Vice Chair, Division of Pediatrics, and a Pediatric Critical Care Physician, Division of Pediatric Critical Care Medicine; Ryan W. Carroll, MD, MPH, is Director, Global Pediatric Critical Care Medicine, and a Pediatric Critical Care Physician, Division of Pediatric Critical Care Medicine; and Allan M. Goldstein, MD, is Surgeon-in-Chief; all at MassGeneral Hospital for Children. Danielle Doucette, RRT, is a Respiratory Therapist and ECMO Coordinator, Respiratory Care Services, and Allan M. Goldstein, MD, is Chief, Division of Pediatric Surgery, Department of Surgery; both at Massachusett..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil D.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Catherine E. Naber, MD, and Neil D. Fernandes, MD, are Pediatric Critical Care Fellows, Division of Pediatric Critical Care Medicine; Manuella Lahoud-Rahme, MD, is a Pediatric Cardiologist, Division of Pediatric Critical Care and Division of Pediatric Cardiology; Phoebe H. Yager, MD, is a Pediatric Critical Care Physician and Chief, Division of Pediatric Critical Care Medicine; Brian M. Cummings, MD, is Medical Director and Vice Chair, Division of Pediatrics, and a Pediatric Critical Care Physician, Division of Pediatric Critical Care Medicine; Ryan W. Carroll, MD, MPH, is Director, Global Pediatric Critical Care Medicine, and a Pediatric Critical Care Physician, Division of Pediatric Critical Care Medicine; and Allan M. Goldstein, MD, is Surgeon-in-Chief; all at MassGeneral Hospital for Children. Danielle Doucette, RRT, is a Respiratory Therapist and ECMO Coordinator, Respiratory Care Services, and Allan M. Goldstein, MD, is Chief, Division of Pediatric Surgery, Department of Surgery; both at Massachusett..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuella","family":"Lahoud-Rahme","sequence":"additional","affiliation":[{"name":"Catherine E. Naber, MD, and Neil D. Fernandes, MD, are Pediatric Critical Care Fellows, Division of Pediatric Critical Care Medicine; Manuella Lahoud-Rahme, MD, is a Pediatric Cardiologist, Division of Pediatric Critical Care and Division of Pediatric Cardiology; Phoebe H. Yager, MD, is a Pediatric Critical Care Physician and Chief, Division of Pediatric Critical Care Medicine; Brian M. Cummings, MD, is Medical Director and Vice Chair, Division of Pediatrics, and a Pediatric Critical Care Physician, Division of Pediatric Critical Care Medicine; Ryan W. Carroll, MD, MPH, is Director, Global Pediatric Critical Care Medicine, and a Pediatric Critical Care Physician, Division of Pediatric Critical Care Medicine; and Allan M. Goldstein, MD, is Surgeon-in-Chief; all at MassGeneral Hospital for Children. Danielle Doucette, RRT, is a Respiratory Therapist and ECMO Coordinator, Respiratory Care Services, and Allan M. Goldstein, MD, is Chief, Division of Pediatric Surgery, Department of Surgery; both at Massachusett..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Doucette","sequence":"additional","affiliation":[{"name":"Catherine E. Naber, MD, and Neil D. Fernandes, MD, are Pediatric Critical Care Fellows, Division of Pediatric Critical Care Medicine; Manuella Lahoud-Rahme, MD, is a Pediatric Cardiologist, Division of Pediatric Critical Care and Division of Pediatric Cardiology; Phoebe H. Yager, MD, is a Pediatric Critical Care Physician and Chief, Division of Pediatric Critical Care Medicine; Brian M. Cummings, MD, is Medical Director and Vice Chair, Division of Pediatrics, and a Pediatric Critical Care Physician, Division of Pediatric Critical Care Medicine; Ryan W. Carroll, MD, MPH, is Director, Global Pediatric Critical Care Medicine, and a Pediatric Critical Care Physician, Division of Pediatric Critical Care Medicine; and Allan M. Goldstein, MD, is Surgeon-in-Chief; all at MassGeneral Hospital for Children. Danielle Doucette, RRT, is a Respiratory Therapist and ECMO Coordinator, Respiratory Care Services, and Allan M. Goldstein, MD, is Chief, Division of Pediatric Surgery, Department of Surgery; both at Massachusett..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan M.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Catherine E. Naber, MD, and Neil D. Fernandes, MD, are Pediatric Critical Care Fellows, Division of Pediatric Critical Care Medicine; Manuella Lahoud-Rahme, MD, is a Pediatric Cardiologist, Division of Pediatric Critical Care and Division of Pediatric Cardiology; Phoebe H. Yager, MD, is a Pediatric Critical Care Physician and Chief, Division of Pediatric Critical Care Medicine; Brian M. Cummings, MD, is Medical Director and Vice Chair, Division of Pediatrics, and a Pediatric Critical Care Physician, Division of Pediatric Critical Care Medicine; Ryan W. Carroll, MD, MPH, is Director, Global Pediatric Critical Care Medicine, and a Pediatric Critical Care Physician, Division of Pediatric Critical Care Medicine; and Allan M. Goldstein, MD, is Surgeon-in-Chief; all at MassGeneral Hospital for Children. Danielle Doucette, RRT, is a Respiratory Therapist and ECMO Coordinator, Respiratory Care Services, and Allan M. Goldstein, MD, is Chief, Division of Pediatric Surgery, Department of Surgery; both at Massachusett..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phoebe H.","family":"Yager","sequence":"additional","affiliation":[{"name":"Catherine E. Naber, MD, and Neil D. Fernandes, MD, are Pediatric Critical Care Fellows, Division of Pediatric Critical Care Medicine; Manuella Lahoud-Rahme, MD, is a Pediatric Cardiologist, Division of Pediatric Critical Care and Division of Pediatric Cardiology; Phoebe H. Yager, MD, is a Pediatric Critical Care Physician and Chief, Division of Pediatric Critical Care Medicine; Brian M. Cummings, MD, is Medical Director and Vice Chair, Division of Pediatrics, and a Pediatric Critical Care Physician, Division of Pediatric Critical Care Medicine; Ryan W. Carroll, MD, MPH, is Director, Global Pediatric Critical Care Medicine, and a Pediatric Critical Care Physician, Division of Pediatric Critical Care Medicine; and Allan M. Goldstein, MD, is Surgeon-in-Chief; all at MassGeneral Hospital for Children. Danielle Doucette, RRT, is a Respiratory Therapist and ECMO Coordinator, Respiratory Care Services, and Allan M. Goldstein, MD, is Chief, Division of Pediatric Surgery, Department of Surgery; both at Massachusett..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian M.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Catherine E. Naber, MD, and Neil D. Fernandes, MD, are Pediatric Critical Care Fellows, Division of Pediatric Critical Care Medicine; Manuella Lahoud-Rahme, MD, is a Pediatric Cardiologist, Division of Pediatric Critical Care and Division of Pediatric Cardiology; Phoebe H. Yager, MD, is a Pediatric Critical Care Physician and Chief, Division of Pediatric Critical Care Medicine; Brian M. Cummings, MD, is Medical Director and Vice Chair, Division of Pediatrics, and a Pediatric Critical Care Physician, Division of Pediatric Critical Care Medicine; Ryan W. Carroll, MD, MPH, is Director, Global Pediatric Critical Care Medicine, and a Pediatric Critical Care Physician, Division of Pediatric Critical Care Medicine; and Allan M. Goldstein, MD, is Surgeon-in-Chief; all at MassGeneral Hospital for Children. Danielle Doucette, RRT, is a Respiratory Therapist and ECMO Coordinator, Respiratory Care Services, and Allan M. Goldstein, MD, is Chief, Division of Pediatric Surgery, Department of Surgery; both at Massachusett..."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan W.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Catherine E. Naber, MD, and Neil D. Fernandes, MD, are Pediatric Critical Care Fellows, Division of Pediatric Critical Care Medicine; Manuella Lahoud-Rahme, MD, is a Pediatric Cardiologist, Division of Pediatric Critical Care and Division of Pediatric Cardiology; Phoebe H. Yager, MD, is a Pediatric Critical Care Physician and Chief, Division of Pediatric Critical Care Medicine; Brian M. Cummings, MD, is Medical Director and Vice Chair, Division of Pediatrics, and a Pediatric Critical Care Physician, Division of Pediatric Critical Care Medicine; Ryan W. Carroll, MD, MPH, is Director, Global Pediatric Critical Care Medicine, and a Pediatric Critical Care Physician, Division of Pediatric Critical Care Medicine; and Allan M. Goldstein, MD, is Surgeon-in-Chief; all at MassGeneral Hospital for Children. Danielle Doucette, RRT, is a Respiratory Therapist and ECMO Coordinator, Respiratory Care Services, and Allan M. Goldstein, MD, is Chief, Division of Pediatric Surgery, Department of Surgery; both at Massachusett..."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"e_1_3_1_2_2","unstructured":"American Academy of Pediatrics. Children and COVID-19: state-level data report. Published April 29 2021. 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Weekly COVID-19 public health report. Published June 3 2020. Accessed June4 2020. https:\/\/www.mass.gov\/doc\/weekly-covid-19-public-health-report-june-3-2020\/download"},{"key":"e_1_3_1_21_2","unstructured":"Extracorporeal Life Support Organization (ELSO). ELSO Live Registry dashboard of ECMO patient data. 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