{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T00:28:19Z","timestamp":1777681699811,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Health Security"],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:p>\n                    We conducted a comprehensive, multiphase laboratory evaluation of the InBios Active Melioidosis Detect (AMD) rapid test, a lateral flow immunoassay designed to detect capsular polysaccharides produced by\n                    <jats:italic toggle=\"yes\">Burkholderia mallei<\/jats:italic>\n                    or\n                    <jats:italic toggle=\"yes\">Burkholderia pseudomallei<\/jats:italic>\n                    , used in conjunction with the Omni Array Reader for the rapid identification of culture isolates of\n                    <jats:italic toggle=\"yes\">B mallei<\/jats:italic>\n                    or\n                    <jats:italic toggle=\"yes\">B pseudomallei<\/jats:italic>\n                    to support clinical diagnosis for response and triage during a mass casualty event, such as a biological attack. The study was conducted at 2 sites to assess the performance of the AMD test. The sensitivity, specificity, and reproducibility of the assay was determined using 5 replicates of 35 inclusivity strains and 64 clinical background strains. A total of 520 tests were performed, which included both positive and negative controls. Results obtained visually and with the Omni Array Reader showed a sensitivity of 92.3% for\n                    <jats:italic toggle=\"yes\">B mallei<\/jats:italic>\n                    and 95.6% for\n                    <jats:italic toggle=\"yes\">B pseudomallei<\/jats:italic>\n                    ; no cross-reactivity was observed with any of the 64 clinical background organisms. The results from this study indicate that the AMD test for the presumptive identification of\n                    <jats:italic toggle=\"yes\">B mallei<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">B pseudomallei<\/jats:italic>\n                    isolates to support clinical diagnosis is highly robust, specific, and sensitive. This evaluation supports the use of this test as a rapid, qualitative assay for the presumptive identification of\n                    <jats:italic toggle=\"yes\">B mallei<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">B pseudomallei<\/jats:italic>\n                    in a clinical setting.\n                  <\/jats:p>","DOI":"10.1089\/hs.2021.0172","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T12:13:05Z","timestamp":1650888785000},"page":"164-171","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Rapid Presumptive Identification of\n                    <i>Burkholderia mallei<\/i>\n                    and\n                    <i>Burkholderia pseudomallei<\/i>\n                    Clinical Isolates Using a Highly Specific Lateral Flow Assay"],"prefix":"10.1177","volume":"20","author":[{"given":"Kodumudi S.","family":"Venkateswaran","sequence":"first","affiliation":[{"name":"Kodumudi S. Venkateswaran, PhD, is Chief Executive Officer, Omni Array Biotechnology, Rockville, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishanth","family":"Parameswaran","sequence":"additional","affiliation":[{"name":"Nishanth Parameswaran, MPH, is Scientist, Omni Array Biotechnology, Rockville, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jawad","family":"Sarwar","sequence":"additional","affiliation":[{"name":"Jawad Sarwar, MS, is Scientist, Omni Array Biotechnology, Rockville, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Plummer","sequence":"additional","affiliation":[{"name":"Andrea Plummer Microbiologist, Tetracore, Inc., Rockville, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Santos","sequence":"additional","affiliation":[{"name":"Alan Santos is Microbiologist, Tetracore, Inc., Rockville, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine A.","family":"Pillai","sequence":"additional","affiliation":[{"name":"Christine A. Pillai is a Oak Ridge Institute for Science and Education Fellow Research Scientist, Molecular Methods Development Branch, Division of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Bowen","sequence":"additional","affiliation":[{"name":"Samantha Bowen, MS, is Project Manager, Science and Technology Directorate, US Department of Homeland Security, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Granville","sequence":"additional","affiliation":[{"name":"Maria Granville, MS, is Project Manager, Science and Technology Directorate, US Department of Homeland Security, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senthamil","family":"Selvan","sequence":"additional","affiliation":[{"name":"Senthamil Selvan, PhD, is Vice President, Omni Array Biotechnology, Rockville, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasanti","family":"Babu","sequence":"additional","affiliation":[{"name":"Prasanti Babu, MS, is a Research Associate, Omni Array Biotechnology, Rockville, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagarajan","family":"Thirunavukkarasu","sequence":"additional","affiliation":[{"name":"Nagarajan Thirunavukkarasu, PhD, is a Microbiologist, Molecular Methods Development Branch, Division of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraja","family":"Venkateswaran","sequence":"additional","affiliation":[{"name":"Neeraja Venkateswaran, PhD, is a Senior Scientist, Tetracore, Inc., Rockville, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashi","family":"Sharma","sequence":"additional","affiliation":[{"name":"Shashi Sharma, PhD, is Principal Investigator, Molecular Methods Development Branch, Division of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen A.","family":"Morse","sequence":"additional","affiliation":[{"name":"Stephen A. Morse, MSPH, PhD, is Senior Scientist, IHRC, Inc., Atlanta, GA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Anderson","sequence":"additional","affiliation":[{"name":"Kevin Anderson, PhD, is Program Manager, Science and Technology Directorate, US Department of Homeland Security, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Hodge","sequence":"additional","affiliation":[{"name":"David R. Hodge, PhD, is Program Manager, Science and Technology Directorate, US Department of Homeland Security, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Segaran P.","family":"Pillai","sequence":"additional","affiliation":[{"name":"Segaran P. Pillai, PhD, FAAM, SM(NRCM), SM(ASCP), is Director, Office of Laboratory Safety, Office of the Commissioner, US Food and Drug Administration, Silver Spring, MD."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,4,22]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40475-015-0042-2"},{"key":"e_1_3_2_3_2","unstructured":"Nguyen HVN Smith ME Hayoun MA. Glanders and melioidosis. In: StatPearls. 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The Japanese biological warfare program: an overview, In: Geissler E, van Courtland Moon JE, eds. Biological and Toxin Weapons: Research, Development and Use from the Middle Ages to 1945. Oxford, UK: Oxford University Press; 1999:127-152."},{"key":"e_1_3_2_14_2","first-page":"153","volume-title":"Biological and Toxin Weapons: Research, Development and Use from the Middle Ages to 1945","author":"Bojtzov V","year":"1999","unstructured":"Bojtzov V, , Geissler E. Military biology in the USSR, 1920-45. In: Geissler E, , van Courtland Moon JE, eds. Biological and Toxin Weapons: Research, Development and Use from the Middle Ages to 1945. Oxford, UK: Oxford University Press;. 1999:153-167."},{"key":"e_1_3_2_15_2","volume-title":"The Soviet Biological Weapons Program: A History","author":"Leitenberg M","year":"2012","unstructured":"Leitenberg M, , Zilinskas RA. The Soviet Biological Weapons Program: A History. Cambridge, MA: Harvard University Press; 2012."},{"key":"e_1_3_2_16_2","first-page":"215","volume-title":"Biological and Toxin Weapons: Research, Development and Use from the Middle Ages to 1945","author":"van Courtland Moon JE","year":"1999","unstructured":"van Courtland Moon JE. US biological warfare planning and preparedness: the dilemmas of policy. In: Geissler E, , van Courtland Moon JE, eds. Biological and Toxin Weapons: Research, Development and Use from the Middle Ages to 1945. Oxford, UK: Oxford University Press;. 1999:215-254."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/124.6.598"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0601.000110"},{"key":"e_1_3_2_19_2","unstructured":"CDC Health Alert Network. Source implicated in fatal case in Georgia: multistate outbreak of non-travel associated Burkholderia pseudomallei infections (mellioidosis) in four patients: Georgia Kansas Minnesota and Texas\u20132021. 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