{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:36:52Z","timestamp":1791225412492,"version":"4.1.0"},"reference-count":89,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Gene Therapy"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1089\/hum.2006.17.1","type":"journal-article","created":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T11:09:14Z","timestamp":1137064154000},"page":"1-9","source":"Crossref","is-referenced-by-count":149,"title":["Lentivirus-Mediated Gene Transfer to the Central Nervous System: Therapeutic and Research Applications"],"prefix":"10.1177","volume":"17","author":[{"given":"Liang-Fong","family":"Wong","sequence":"first","affiliation":[{"name":"Oxford BioMedica (UK), Medawar Centre, Oxford Science Park, Oxford OX4 4GA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Goodhead","sequence":"additional","affiliation":[{"name":"Oxford BioMedica (UK), Medawar Centre, Oxford Science Park, Oxford OX4 4GA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Prat","sequence":"additional","affiliation":[{"name":"Oxford BioMedica (UK), Medawar Centre, Oxford Science Park, Oxford OX4 4GA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriacos A.","family":"Mitrophanous","sequence":"additional","affiliation":[{"name":"Oxford BioMedica (UK), Medawar Centre, Oxford Science Park, Oxford OX4 4GA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Kingsman","sequence":"additional","affiliation":[{"name":"Oxford BioMedica (UK), Medawar Centre, Oxford Science Park, Oxford OX4 4GA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas D.","family":"Mazarakis","sequence":"additional","affiliation":[{"name":"Oxford BioMedica (UK), Medawar Centre, Oxford Science Park, Oxford OX4 4GA, UK."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"p_50","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2005.16.741"},{"key":"p_51","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2004.11.002"},{"key":"p_52","doi-asserted-by":"crossref","first-page":"10302","DOI":"10.1523\/JNEUROSCI.22-23-10302.2002","volume":"22","author":"AZZOUZ M.","year":"2002","journal-title":"J. Neurosci."},{"key":"p_53","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.600"},{"key":"p_54","doi-asserted-by":"publisher","DOI":"10.1172\/JCI22922"},{"key":"p_55","doi-asserted-by":"publisher","DOI":"10.1038\/nature02544"},{"key":"p_56","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200404290-00011"},{"key":"p_58","doi-asserted-by":"publisher","DOI":"10.3727\/000000005783983106"},{"key":"p_59","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7409"},{"key":"p_60","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-200308000-00008"},{"key":"p_61","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(03)00069-8"},{"key":"p_62","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2005.16.1133"},{"key":"p_63","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200419205"},{"key":"p_64","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2004.45.Suppl.28"},{"key":"p_65","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.01.007"},{"key":"p_66","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.5.2603"},{"key":"p_67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.082011999"},{"key":"p_68","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00046"},{"key":"p_70","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1104"},{"key":"p_71","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2001.0388"},{"key":"p_72","doi-asserted-by":"publisher","DOI":"10.1089\/10430340050016256"},{"key":"p_73","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.501"},{"key":"p_74","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0407976101"},{"key":"p_75","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409072102"},{"key":"p_76","doi-asserted-by":"crossref","first-page":"8463","DOI":"10.1128\/JVI.72.11.8463-8471.1998","volume":"72","author":"DULL T.","year":"1998","journal-title":"J. Virol."},{"key":"p_77","first-page":"1589","volume":"12","author":"DURING M.J.","year":"2001","journal-title":"Hum. Gene Ther."},{"key":"p_78","doi-asserted-by":"publisher","DOI":"10.1159\/000017069"},{"key":"p_79","first-page":"245","volume":"261","author":"GALIMI F.","year":"2002","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"p_80","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2004.08.021"},{"key":"p_81","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.8006"},{"key":"p_82","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2004.15.934"},{"key":"p_83","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1122-04.2004"},{"key":"p_84","doi-asserted-by":"publisher","DOI":"10.1038\/nm850"},{"key":"p_85","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501507102"},{"key":"p_86","doi-asserted-by":"crossref","first-page":"5587","DOI":"10.1523\/JNEUROSCI.20-15-05587.2000","volume":"20","author":"HOTTINGER A.F.","year":"2000","journal-title":"J. Neurosci."},{"key":"p_87","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10719"},{"key":"p_88","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.18.9378-9388.2002"},{"key":"p_89","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1128\/JVI.72.1.811-816.1998","volume":"72","author":"KIM V.N.","year":"1998","journal-title":"J. Virol."},{"key":"p_90","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(03)00164-4"},{"key":"p_91","doi-asserted-by":"publisher","DOI":"10.1038\/nn1175"},{"key":"p_92","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2004.10.006"},{"key":"p_93","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301889"},{"key":"p_94","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5492.767"},{"key":"p_95","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.10.4839-4852.2000"},{"key":"p_96","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2004.10.026"},{"key":"p_97","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2003.tb00035.x"},{"key":"p_98","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.152339799"},{"key":"p_99","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.06.008"},{"key":"p_100","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405313101"},{"key":"p_101","doi-asserted-by":"publisher","DOI":"10.1126\/science.1067081"},{"key":"p_102","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-06-01992.2003"},{"key":"p_103","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.19.2109"},{"key":"p_104","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400171"},{"key":"p_105","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1231012100"},{"key":"p_107","doi-asserted-by":"publisher","DOI":"10.1089\/10430340252792486"},{"key":"p_108","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.60.1.69"},{"key":"p_109","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.12.6344-6359.2004"},{"key":"p_110","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251682798"},{"key":"p_111","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.712"},{"key":"p_112","doi-asserted-by":"publisher","DOI":"10.1097\/01.WCB.0000110532.48786.46"},{"key":"p_113","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-005-0649-1"},{"key":"p_114","doi-asserted-by":"publisher","DOI":"10.1038\/nm1205"},{"key":"p_115","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2000.0190"},{"key":"p_116","doi-asserted-by":"publisher","DOI":"10.1038\/nm1207"},{"key":"p_117","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg305"},{"key":"p_118","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.22.10589-10599.2000"},{"key":"p_119","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(02)46072-7"},{"key":"p_120","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-21-08408.2001"},{"key":"p_121","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301626"},{"key":"p_122","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2005.16.1227"},{"key":"p_123","doi-asserted-by":"publisher","DOI":"10.1038\/nn1531"},{"key":"p_124","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2003.09.006"},{"key":"p_125","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-004-6046-8"},{"key":"p_126","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2004.11.008"},{"key":"p_127","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg285"},{"key":"p_128","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(03)00130-4"},{"key":"p_129","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402107101"},{"key":"p_130","doi-asserted-by":"publisher","DOI":"10.1038\/nm1239"},{"key":"p_131","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403954101"},{"key":"p_132","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2002.0542"},{"key":"p_133","doi-asserted-by":"publisher","DOI":"10.1006\/mthe.2002.0584"},{"key":"p_134","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.06.076"},{"key":"p_135","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2003.09.017"},{"key":"p_136","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2004.08.026"},{"key":"p_138","doi-asserted-by":"publisher","DOI":"10.1038\/90242"},{"key":"p_139","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5398.88"},{"key":"p_140","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2005.05.017"},{"key":"p_141","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19981115)54:4<554::AID-JNR12>3.0.CO;2-M"},{"key":"p_142","doi-asserted-by":"crossref","first-page":"9873","DOI":"10.1128\/JVI.72.12.9873-9880.1998","volume":"72","author":"ZUFFEREY R.","year":"1998","journal-title":"J. Virol."}],"container-title":["Human Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/hum.2006.17.1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:55:05Z","timestamp":1777449305000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/hum.2006.17.1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":89,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1089\/hum.2006.17.1"],"URL":"https:\/\/doi.org\/10.1089\/hum.2006.17.1","relation":{},"ISSN":["1043-0342","1557-7422"],"issn-type":[{"value":"1043-0342","type":"print"},{"value":"1557-7422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}