{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:12:27Z","timestamp":1790017947200,"version":"4.0.1"},"reference-count":107,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.liebertpub.com\/nv\/resources-tools\/text-and-data-mining-policy\/121\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Gene Therapy"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1089\/hum.2015.059","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T01:31:46Z","timestamp":1434418306000},"page":"664-679","source":"Crossref","is-referenced-by-count":22,"title":["Preclinical Assessment of Mutant Human TRIM5\u03b1 as an Anti-HIV-1 Transgene"],"prefix":"10.1177","volume":"26","author":[{"given":"Ulrike","family":"Jung","sequence":"first","affiliation":[{"name":"Division of Molecular & Cell Biology, Beckman Research Institute of the City of Hope, Duarte, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Urak","sequence":"additional","affiliation":[{"name":"Division of Molecular & Cell Biology, Beckman Research Institute of the City of Hope, Duarte, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Veillette","sequence":"additional","affiliation":[{"name":"Laboratory of Retrovirology, Department of Medical Biology, Universit\u00e9 du Qu\u00e9bec, Trois-Rivi\u00e8res, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-\u00c9dith","family":"Nepveu-Traversy","sequence":"additional","affiliation":[{"name":"Laboratory of Retrovirology, Department of Medical Biology, Universit\u00e9 du Qu\u00e9bec, Trois-Rivi\u00e8res, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quang Toan","family":"Pham","sequence":"additional","affiliation":[{"name":"Laboratory of Retrovirology, Department of Medical Biology, Universit\u00e9 du Qu\u00e9bec, Trois-Rivi\u00e8res, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Hamel","sequence":"additional","affiliation":[{"name":"Laboratory of Retrovirology, Department of Medical Biology, Universit\u00e9 du Qu\u00e9bec, Trois-Rivi\u00e8res, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Rossi","sequence":"additional","affiliation":[{"name":"Division of Molecular & Cell Biology, Beckman Research Institute of the City of Hope, Duarte, California"},{"name":"Graduate School of Biological Sciences, City of Hope National Medical Center, Duarte, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Berthoux","sequence":"additional","affiliation":[{"name":"Laboratory of Retrovirology, Department of Medical Biology, Universit\u00e9 du Qu\u00e9bec, Trois-Rivi\u00e8res, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1663"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300662"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2217\/fvl.11.113"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-7-23"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nature02343"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.1.726-731.2003"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162299499"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.2.869-875.2005"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.21.11816-11822.2004"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.03.013"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509996103"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.24.15567-15572.2005"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200706154"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00210-10"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02318-06"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002009"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01052-06"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2005.12.040"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000074"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.21.11739-11750.2004"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nature09976"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.05.003"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2010.40"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402876101"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.12.7883-7888.2005"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.07.291"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2010.269"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.12.042"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2013.01.013"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00270-06"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-10-25"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-07-294520"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/nm0596-545"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.2763"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000365"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/nm998"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01277-07"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.7.3617-3623.2006"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05201-11"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01313-13"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2014.02.013"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.09.018"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.4.2051-2054.2006"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80103-X"},{"key":"B45","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1128\/JVI.59.2.284-291.1986","volume":"59","author":"Adachi A","year":"1986","journal-title":"J Virol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00758-10"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80828-4"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0997-871"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-0016(03)00165-5"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2006.05534.x"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-5-1027"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.16.8957-8951.2003"},{"key":"B53","doi-asserted-by":"crossref","first-page":"8966","DOI":"10.1128\/JVI.73.11.8966-8974.1999","volume":"73","author":"Trkola A","year":"1999","journal-title":"J Virol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-4-68"},{"key":"B55","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1128\/JVI.66.4.2232-2239.1992","volume":"66","author":"Kimpton J","year":"1992","journal-title":"J Virol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1002\/bit.21811"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.09.019"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003667"},{"key":"B59","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.4049\/jimmunol.152.8.4183","volume":"152","author":"Qian J","year":"1994","journal-title":"J Immunol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01804-12"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/12.12.1035"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00703-07"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2014.52"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.10.007"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02272-12"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M910346199"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/35085597"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2012.01108.x"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302537"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411189200"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.7a.1266"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00375.x"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-6-137"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203239"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071914"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1680708"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.12.1351"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2010.085"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.17.7806-7819.2004"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.145.7.1471"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90755-1"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204383"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1126\/science.6200935"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802905"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002020"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-145-1_19"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300157"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1002\/jgm.1078"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.21.11531-11535.2003"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2012.22"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80066-5"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.2.568-575.2004"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00666-08"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05066-11"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.3.1067-1076.2006"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00515-4"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000462"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.2.1006-1011.2004"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.5.3139-3145.2005"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030200"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0505659102"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.80.10.4683-4690.2006"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2006.03.015"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1316194110"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M701846200"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.05.010"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2884"}],"container-title":["Human Gene Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.liebertpub.com\/doi\/full-xml\/10.1089\/hum.2015.059","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.liebertpub.com\/doi\/pdf\/10.1089\/hum.2015.059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:56:10Z","timestamp":1777449370000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1089\/hum.2015.059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":107,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1089\/hum.2015.059"],"URL":"https:\/\/doi.org\/10.1089\/hum.2015.059","relation":{},"ISSN":["1043-0342","1557-7422"],"issn-type":[{"value":"1043-0342","type":"print"},{"value":"1557-7422","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10]]}}}