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In this context, gene therapy may offer a new avenue for patients with PDAC. In this review, we explore the research currently ongoing in French laboratories aimed at defeating PDAC using nonviral therapeutic gene delivery, targeted transgene expression, or oncolytic virotherapy that recently or will soon bridge the gap between experimental models of cancer and clinical trials. These studies are likely to change clinical practice or thinking about PDAC management, as they represent a major advance not only for PDAC but may also significantly influence the field of gene-based molecular treatment of cancer.<\/jats:p>","DOI":"10.1089\/hum.2015.141","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T05:11:56Z","timestamp":1448428316000},"page":"127-133","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["The Promise of Gene Therapy for Pancreatic Cancer"],"prefix":"10.1177","volume":"27","author":[{"given":"Georges","family":"Vassaux","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Nice Sophia Antipolis","place":["France"]},{"name":"Laboratoire TIRO","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assia","family":"Angelova","sequence":"additional","affiliation":[{"name":"German Cancer Research Center (DKFZ)","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Baril","sequence":"additional","affiliation":[{"name":"CNRS UPR4301 and University of Orl\u00e9ans","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Midoux","sequence":"additional","affiliation":[{"name":"CNRS UPR4301 and University of Orl\u00e9ans","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Rommelaere","sequence":"additional","affiliation":[{"name":"German Cancer Research Center (DKFZ)","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Cordelier","sequence":"additional","affiliation":[{"name":"INSERM","place":["France"]},{"name":"Universit\u00e9 Toulouse III-Paul Sabatier","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,11,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21166"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164368"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09515"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011923"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.4869"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.5742"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304369"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq509"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.01.007"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2014.04.021"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.10.007"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.7516"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.228"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2015.1"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2005.16.1175"},{"key":"e_1_3_3_17_2","first-page":"6124","article-title":"Antitumor effect of in vivo somatostatin receptor subtype 2 gene transfer in primary and metastatic pancreatic cancer models","volume":"62","author":"Vernejoul F","year":"2002","unstructured":"Vernejoul F, , Faure P, , Benali N, et al. 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