{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:21:03Z","timestamp":1788916863099,"version":"build-2803163510"},"reference-count":35,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Human Gene Therapy"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>\n                    In a model of growth-restricted sheep pregnancy, it was previously demonstrated that transient uterine artery VEGF overexpression can improve fetal growth. This approach was tested in guinea-pig pregnancies, where placental physiology is more similar to humans. Fetal growth restriction (FGR) was attained through peri-conceptual nutrient restriction in virgin guinea pigs. Ad.VEGF-A\n                    <jats:sub>165<\/jats:sub>\n                    or Ad.LacZ (1\u2009\u00d7\u200910\n                    <jats:sup>10<\/jats:sup>\n                    vp) was applied at mid-gestation via laparotomy, delivered externally to the uterine circulation with thermosensitive gel. At short-term (3\u20138 days post surgery) or at term gestation, pups were weighed, and tissues were sampled for vector spread analysis, VEGF expression, and its downstream effects. Fetal weight at term was increased (88.01\u2009\u00b1\u200913.36\u2009g;\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200926) in Ad.VEGF-A\n                    <jats:sub>165<\/jats:sub>\n                    -treated animals compared with Ad.LacZ-treated animals (85.52\u2009\u00b1\u200913.00\u2009g;\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200919;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    \u2009=\u20090.028). The brain, liver, and lung weight and crown rump length were significantly larger in short-term analyses, as well as VEGF expression in transduced tissues. At term, molecular analyses confirmed the presence of\n                    <jats:italic toggle=\"yes\">VEGF<\/jats:italic>\n                    transgene in target tissues but not in fetal samples. Tissue histology analysis and blood biochemistry\/hematological examination were comparable with controls. Uterine artery relaxation in Ad.VEGF-A\n                    <jats:sub>165<\/jats:sub>\n                    -treated dams was higher compared with Ad.LacZ-treated dams. Maternal uterine artery Ad.VEGF-A\n                    <jats:sub>165<\/jats:sub>\n                    increases fetal growth velocity and term fetal weight in growth-restricted guinea-pig pregnancy.\n                  <\/jats:p>","DOI":"10.1089\/hum.2016.046","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T22:44:05Z","timestamp":1471387445000},"page":"997-1007","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":43,"title":["Maternal Therapy with Ad.VEGF-A\n                    <sub>165<\/sub>\n                    Increases Fetal Weight at Term in a Guinea-Pig Model of Fetal Growth Restriction"],"prefix":"10.1177","volume":"27","author":[{"given":"Anna M.","family":"Swanson","sequence":"first","affiliation":[{"name":"Institute for Women's Health","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo A.","family":"Rossi","sequence":"additional","affiliation":[{"name":"Institute for Women's Health","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keren","family":"Ofir","sequence":"additional","affiliation":[{"name":"Institute for Women's Health","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedanta","family":"Mehta","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Biology and Medicine","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Boyd","sequence":"additional","affiliation":[{"name":"Biological Services Unit, Royal Veterinary College, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Barker","sequence":"additional","affiliation":[{"name":"Biological Services Unit, Royal Veterinary College, London, United Kingdom."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Ledwozyw","sequence":"additional","affiliation":[{"name":"Institute for Women's Health","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Institute for Women's Health","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Martin","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Biology and Medicine","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Zachary","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Biology and Medicine","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Sebire","sequence":"additional","affiliation":[{"name":"Institute of Child Health","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M.","family":"Peebles","sequence":"additional","affiliation":[{"name":"Institute for Women's Health","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"David","sequence":"additional","affiliation":[{"name":"Institute for Women's Health","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70513-8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4401"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000253215.79121.75"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073059"},{"key":"e_1_3_3_6_2","first-page":"1000","article-title":"Quantitative estimation of human uterine artery blood flow and pelvic blood flow redistribution in pregnancy","volume":"80","author":"Palmer SK","year":"1992","unstructured":"Palmer SK, , Zamudio S, , Coffin C, et al. 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