{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:51:34Z","timestamp":1789865494237,"version":"4.0.1"},"reference-count":32,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Human Gene Therapy"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>\n                    Retinal detachment is an acute disorder in humans that is caused by trauma or disease, and it can often lead to permanent visual deficits that result from the death of photoreceptors in the retina. The final pathway for photoreceptor cell death is apoptosis and necroptosis. The X-linked inhibitor of apoptosis (XIAP) has been shown to block both of these cell death pathways. This study tested the effects of XIAP on photoreceptor survival in a feline model of retinal detachment. The study was performed in 12 cats, divided into two experimental groups. Six animals received a subretinal injection of adeno-associated virus (AAV) carrying\n                    <jats:italic toggle=\"yes\">XIAP<\/jats:italic>\n                    , and six animals received AAV carrying green fluorescent protein (\n                    <jats:italic toggle=\"yes\">GFP<\/jats:italic>\n                    ) as a control. Three weeks after viral delivery, retinas were detached by injecting C\n                    <jats:sub>3<\/jats:sub>\n                    F\n                    <jats:sub>8<\/jats:sub>\n                    gas into the subretinal space. Optical coherence tomography revealed that the retinal detachments resolved within 3\u20136 weeks as the gas was slowly resorbed. Analysis of histological sections through the plane of the detachment showed significant preservation of the photoreceptor layer in AAV-XIAP-treated animals compared to AAV-GFP-treated animals at 9 weeks after the detachment. XIAP-treated detached retinas were similar to intact controls. These studies support the potential for XIAP therapy in the treatment of human retinal detachment.\n                  <\/jats:p>","DOI":"10.1089\/hum.2016.161","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T02:24:23Z","timestamp":1490322263000},"page":"482-492","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Overexpression of the X-Linked Inhibitor of Apoptosis Protects Against Retinal Degeneration in a Feline Model of Retinal Detachment"],"prefix":"10.1177","volume":"28","author":[{"given":"Sarah J.","family":"Wassmer","sequence":"first","affiliation":[{"name":"University of Ottawa","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Leonard","sequence":"additional","affiliation":[{"name":"University of Ottawa","place":["Canada"]},{"name":"Ottawa Hospital Research Institute","place":["Canada"]},{"name":"Eye Institute","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart G.","family":"Coupland","sequence":"additional","affiliation":[{"name":"University of Ottawa","place":["Canada"]},{"name":"University of Ottawa","place":["Canada"]},{"name":"Ottawa Hospital Research Institute","place":["Canada"]},{"name":"Eye Institute","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam N.","family":"Baker","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Research Institute","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Eye Institute","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Hauswirth","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Tsilfidis","sequence":"additional","affiliation":[{"name":"University of Ottawa","place":["Canada"]},{"name":"University of Ottawa","place":["Canada"]},{"name":"Ottawa Hospital Research Institute","place":["Canada"]},{"name":"Eye Institute","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,6,1]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"25","article-title":"Retinal detachment","volume":"16","author":"Jalali S","year":"2003","unstructured":"Jalali S. 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